Prologue: Signal transduction, origins and personalities.
First messengers.
Receptors.
GTP-binding proteins and signal transduction.
Effector enzymes coupled to GTP-binding proteins: adenylyl cyclase
and phospholipase.
The regulation of visual transduction.
Calcium and signal transduction.
Calcium signalling.
Phosphorylation and dephosphorylation:protein kinases A and C.
Growth Factors :setting the framework.
Signalling pathways operated by receptor protein tyrosine
kinases.
Signalling pathways operated by non-receptor protein tyrosine
kinases.
Phosphoinositide 3-kinases.
Signal transduction to and from adhesion molecules.
Adhesion molecules and trafficking of leukocytes.
Signalling through receptor bound protein serine-threonine
kinases.
Protein dephosphorylation and protein phosphorylation.
Protein domains and signal transduction.
* Coherent, precise text providing insight in depth to a subject
that is central to cell biology and fundamental to many areas of
biomedicine
* Conceptual colour artwork assists with the comprehension of key
topics
* Extensive referencing provides an invaluable link to the core and
historical literature
* Margin notes highlighting milestones in the evolution of our
understanding of signalling mechanisms
Bastien D. Gomperts
"Signal Transduction is indispensable for modern life sciences." -BIOELECTROCHEMISTRY (April 2003) "...most useful to senior undergrad and grad students entering the field, but will also provide a valuable reference for established researchers." -CELL "The text is strikingly comprehensive...Written with a single voice, the chapters integrate elegantly with one another, and provide the reader with both broad and comprehensive viewpoints...Remarkably current and up-to-date, the book promises to be a core text for graduate and advanced undergraduate courses in cell signaling and molecular cell biology, and a valuable reference book for all scientists whose work involves mechanisms of cell communication." -Michael B. Yaffe, M.I.T.
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