Table of Contents

VOLUME 1

PART 1 SCIENTIFIC PRINCIPLES OF RESPIRATORY MEDICINE

SECTION A: Anatomy and Development of the Respiratory Tract

1 Anatomy of the Lungs

2 Lung Growth and Development

3 Genetics of Lung Disease

SECTION B: Respiratory Physiology

4 Ventilation, Blood Flow, and Gas Exchange

5 Respiratory System Mechanics and Energetics

6 Pulmonary Circulation and Regulation of Fluid Balance

7 Acid-Base Balance

SECTION C: Defense Mechanisms and Immunology

8 Alveolar Epithelium and Pulmonary Surfactant

9 Alveolar Epithelium and Fluid Transport

10 Airway Epithelium and Mucous Secretion

11 Aerosol Deposition and Clearance

12 Innate Immunity

13 Adaptive Immunity

SECTION D: Respiratory Pathology and Inflammation

14 Pathology: Malignant and Interstitial Lung Diseases

15 Injury and Repair

PART 2 DIAGNOSIS AND EVALUATION OF RESPIRATORY DISEASE

SECTION E: Diagnosis

16 History and Physical Examination

17 Microbiologic Diagnosis of Lung Infection

18 Thoracic Radiology: Noninvasive Diagnostic Imaging

19 Thoracic Radiology: Invasive Diagnostic Imaging and Image-Guided Interventions

20 Ultrasonography

21 Positron Emission Tomography

22 Diagnostic Bronchoscopy

23 Therapeutic Bronchoscopy

24 Thoracoscopy

SECTION F: Evaluation

25 Pulmonary Function Testing

26 Clinical Exercise Testing

27 Preoperative Evaluation

28 Evaluation of Respiratory Impairment and Disability

PART 3 CLINICAL RESPIRATORY MEDICINE

SECTION G: Symptoms of Respiratory Disease and Their Management

29 Dyspnea

30 Cough

31 Chest Pain

SECTION H: Infectious Diseases of the Lungs

32 Viral Infections

33 Bacterial Pneumonia and Lung Abscess

34 Ventilator-Associated Pneumonia

35 Tuberculosis

36 Nontuberculous Mycobacterial Infections

37 Endemic Mycoses

38 Opportunistic Mycoses

39 Parasitic Infections

40 Bioterrorism

SECTION I: Obstructive Diseases

41 Asthma: Pathogenesis and Phenotypes

42 Asthma: Clinical Diagnosis and Management

43 COPD: Pathogenesis and Natural History

44 COPD: Clinical Diagnosis and Management

45 Genetics in Asthma and COPD

46 Smoking Hazards and Cessation

47 Cystic Fibrosis

48 Bronchiectasis

49 Upper Airway Disorders

50 Bronchiolitis and Other Intrathoracic Airway Disorders

VOLUME 2

SECTION J: Neoplasms of the Lung

51 Biology of Lung Cancer

52 Epidemiology of Lung Cancer

53 Clinical Aspects of Lung Cancer

54 Rare Primary Lung Tumors

55 Metastatic Malignant Tumors

56 Benign Lung Tumors

SECTION K: Disorders of the Pulmonary Circulation

57 Pulmonary Thromboembolism

58 Pulmonary Hypertension

59 Pulmonary Hypertension due to Lung Disease

60 Pulmonary Vasculitis

61 Pulmonary Vascular Abnormalities

62 Pulmonary Edema

SECTION L: Infiltrative and Interstitial Lung Diseases

63 Idiopathic Interstitial Pneumonias

64 Hypersensitivity Pneumonitis

65 Connective Tissue Diseases

66 Sarcoidosis

67 Alveolar Hemorrhage and Rare Infiltrative Diseases

68 Eosinophilic Lung Diseases

69 Lymphangioleiomyomatosis

70 Pulmonary Alveolar Proteinosis Syndrome

71 Drug-Induced Pulmonary Disease

SECTION M: Environmental and Occupational Hazards

72 Asthma in the Workplace

73 Pneumoconioses

74 Indoor and Outdoor Air Pollution

75 Acute Responses to Toxic Exposures

76 Trauma and Blast Injuries

77 High Altitude

78 Diving Medicine

SECTION N: Disorders of the Pleura

79 Pleural Effusion

80 Pleural Infections

81 Pneumothorax, Chylothorax, Hemothorax, and Fibrothorax

82 Pleural Tumors

SECTION O: Disorders of the Mediastinum

83 Mediastinal Tumors and Cysts

84 Pneumomediastinum and Mediastinitis

SECTION P: Disorders of Sleep and Control of Breathing

85 Control of Breathing and Upper Airways During Sleep

86 Hypocapnia and Hypercapnia

87 Consequences of Sleep Disruption

88 Obstructive Sleep Apnea

89 Central Sleep Apnea

SECTION Q: Respiratory Manifestations of Extrapulmonary Disorders

90 Pulmonary Complications of HIV Infection

91 Pulmonary Complications of Stem Cell and Solid Organ Transplantation

92 Pulmonary Complications of Primary Immunodeficiencies

93 Pulmonary Complications of Abdominal Diseases

94 Pulmonary Complications of Hematologic Diseases

95 Pulmonary Complications of Endocrine Diseases

96 The Lungs in Obstetric and Gynecologic Diseases

97 The Respiratory System and Neuromuscular Diseases

98 The Respiratory System and Chest Wall Diseases

SECTION R: Management of Respiratory Failure

99 Acute Ventilatory Failure

100 Acute Hypoxemic Respiratory Failure and ARDS

101 Mechanical Ventilation

102 Noninvasive Ventilation

103 Extracorporeal Support of Gas Exchange

104 End-of-Life Care in Respiratory Failure

105 Pulmonary Rehabilitation

106 Lung Transplantation

About the Author

Professor Emeritus, Department of Medicine, University of California San Francisco, San Francisco, California Professor Emeritus
Division of Pulmonary and Critical Care
University of California, San Francisco Professor and Chief
Division of Experimental Medicine
University of California, San Francisco Dean, UCSF School of Medicine

Vice Chancellor, Medical Affairs

University of California, San Francisco Professor

Department of Medicine

University of California, San Francisco

San Francisco, CA

Reviews

REVIEWS OF THE LAST EDITION: "Without a doubt, this text is a must for serious students of pulmonary medicine, whether in training, academic tenure, or mature clinical practice." - JAMA REVIEW OF 4th EDITION: "It goes without saying that this is a thorough, in-depth review of chest medicine and as far as I could see, leaves nothing out. I was pleased to see this is a book for active physicians rather than researchers or scientists. It is aimed squarely at the specialists, but generalists such as GPs or specialists in other but related disciplines would also find this book a good reference source. I also liked the principal that associated non-respiratory problems are covered in detail. Take for example Sarcoidosis, which has always been classified as a chest disease, but is also a multi-system disease. The chapter on Sarcoidosis is an excellent review of the whole topic and not just the pulmonary aspects. In addition, there are excellent chapters on issues that you don't always find such as air pollution, high altitude and diving medicine. Importantly the book is readable and relevant to physicians and adopts a well-rounded approach to informing the doctor what he or she needs to know. The depth of detail achieved is just right, and this book has an encyclopaedic feel to it. There are plenty of illustrations in the book but in the main, this is primarily a text-based reference source."

June 2006, Dr. Harry Brown, www.univadis.com