Genetics and Analysis of Quantitative Traits


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Table of Contents

I. Foundations of Quantitative Genetics

*An Overview of Quantitative Genetics

*Properties of Distributions

*Covariance, Regression, and Correlation

*Properties of Single Loci

*Sources of Genetic Variation for Multilocus Traits

*Components of Environmental Variation

*Resemblance between Relatives

*Introduction to Matrix Algebra and Linear Models

*Analysis of Line Crosses

*Inbreeding Depression

*Matters of Scale

II. Quantitative Trait Loci

Polygenes and Polygenic Mutation

*Detecting Major Genes

*Basic Concepts of Marker-Based Analysis

*Mapping and Characterizing QTLs: Inbred-Line Crosses

*Mapping and Characterizing QTLs: Outbred Populations

III. Estimation Procedures

Parent-Offspring Regression

*Sib Analysis

*Twins and Clones

*Cross-Classified Designs

*Correlations Between Characters

*Genotype x Environment Interaction

*Maternal Effects

*Sex Linkage and Sexual Dimorphism

*Threshold Characters

*Estimation of Breeding Values

*Variance-Component Estimation with Complex Pedigrees


A1. Expectations, Variances and Covariances of Compound Variables

A2. Path Analysis

A3.  Further Topics in Matrix Algebra and Linear Models

A4. Maximum Likelihood Estimation and Likelihood-Ratio Tests

A5. Computing the Power of Statistical Tests

About the Author

Michael Lynch is Distinguished Professor of Biology at Indiana University.

Bruce Walsh is a Professor in the Department of Ecology and Evolutionary Biology at the University of Arizona.


"I have nothing but the highest praise for this book, which will surely stand as the definitive treatment for many years to come. The content is comprehensive, the writing clear and concise, and the overall impression is of a masterly tour de force."
--Warren J. Ewens, American Journal of Human Biology
"This important and useful book will have a permanent place on my desktop. Not only is this an essential reference book, but it is also an excellent textbook."
--Christopher J. Basten, Theoretical Population Biology
"Conclusively, this book is to be highly recommended for anyone interested in a closer and clearer look at nature's most valuable beauty--its genetic variability."
--Elias Anastassopoulos, Economic Botany

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