Table of Contents

Teaching Guide; Cancer and Somatic Evolution; Mathematical Modeling of Tumorigenesis; Basic Growth Dynamics and Deterministic Models: Single Species Growth; Two Species Competition Dynamics; Competition Between Genetically Stable and Unstable Cells; Chromosomal Instability and Tumor Growth; Angiogenesis Inhibitors, Promoters, and Spatial Growth; Evolutionary Dynamics and Stochastic Models: Evolutionary Dynamics of Tumor Initiation Through Oncogenes: The Gain-of-Function Model; Evolutionary Dynamics of Tumor Initiation Through Tumor-Suppressor Genes: The Loss-of-Function Model and Stochastic Tunneling; Microsatellite and Chromosomal Instability in Sporadic and Familial Cancers; Evolutionary Dynamics in Hierarchical Populations; Spatial Evolutionary Dynamics of Tumor Initiation; Complex Tumor Dynamics in Space; Stochastic Modeling of Cellular Growth, Treatment, and Resistance Generation; Evolutionary Dynamics of Drug Resistance in Chronic Myeloid Leukemia; Advanced Topics: Evolutionary Dynamics of Stem-Cell Driven Tumor Growth; Tumor Growth Kinetics and Disease Progression; Epigenetic Changes and The Rate of DNA Methylation; Telomeres and Cancer Protection; Gene Therapy and Oncolytic Virus Therapy; Immune Responses, Tumors Growth, and Therapies; Towards Higher Complexities: Social Interactions.