Table of Contents

Table of Contents

Preface to the Second Edition

Preface to the First Edition

Abbreviations

Chapter 1. Introduction
The Fundamentals Still Pertain
Principles of Effective and Efficient Programming
The Basis of DBS Effects

Chapter 2. Principles of DBS Electronics
Electricity
Electronics
Note Regarding Impedances

Chapter 3. Principles of Electrophysiology
Therapeutic Mechanisms versus Delivery of Therapy
The Neuron
Neuronal Electronics
Voltage Gated Ionic Conductance Channels and Action Potentials
Downstream Secondary Issues

Chapter 4. Controlling the Flow of Electrical Charges
Orientation of the Lines of Electrical Force
Orthodromic and Antidromic Conduction of Action Potentials
Axon Diameter
Electrode Configurations
Current Intensity in Monopolar and Bipolar Electrode Configurations
Segmented DBS Leads

Chapter 5. DBS Safety
The Range of Safety Concerns
Injury Secondary to Electricity
Medical Complications
Adverse Effects Related to Activation of Neural Networks
The Potential Psychosocial Consequences of DBS

Chapter 6. Nervous System Responses to DBS
Knowledge of Nervous System Responses versus Knowledge of Therapeutic Mechanisms
Effects Mediated by Voltage-Gated Ionic Conductance Channels in the Neuronal Membrane
Post-Hyperpolarization Rebound Excitation, Depolarization Blockade, and Neurotransmitter Exhaustion
Dissociation of Effects on Action Potential Initiating Segment, Dendrites, and Cell Bodies
Network Effects of DBS
Critically Important Caveats Concerning Interpretation of Nervous System Responses to DBS
Reentry Propagations and Resonance
Synchronization Among Neurons
Interactions Between DBS Pulse in Intrinsic Neuronal Mechanisms
Effects on Behaviorally Related Intrinsic Neuronal Dynamic
Temporal Evolution of Nervous System Responses

Chapter 7. DBS Effects on Motor Control
Orchestration of Motor Unit Activities
Orchestration of Motor Unit Recruitment and De-Recruitment over Different Time Scales
Lessons to be Learned

Chapter 8. Pathophysiological Mechanisms
The Globus Pallidus Interna Rate Theory
Excessively High Beta Oscillations
Excessive Synchronization of Neuronal Activities
Excessive Bursting
The Systems Oscillators Theory

Chapter 9. Approaches to Programming
Battery Life
DBS Contact Nomenclature
Prior to DBS Programming
When to Program DBS
Conceptual Approaches
The Growing Importance of Monopolar Surveys
Detection of a Response is Critical
Programming for Optimal Benefit in the Absence of Adverse Effects
Programming to Prevent Adverse Effects
Exiting the DBS Programming Session

Chapter 10. Clinical Assessments
Clinical Assessments by Disease
Clinical Assessment of Corticospinal and Corticobulbar Stimulation
Clinical Assessment of Speech, Language and Swallowing
Hints to Clinical Evaluations

Chapter 11. Approach to Subthalamic Nucleus
Regional Anatomy of the Subthalamic Nucleus
Adverse Effects Created by the Position of the DBS Lead Relative to the STN
Approach to STN DBS for Parkinson's Disease

Chapter 12. Approach to Globus Pallidus Internal
Regional Anatomy of the Globus Pallidus Internal (GPi) Segment
Adverse Effects Resulting from the Position of the DBS Lead Relative to the GPi
Approaches to GPi DBS for Parkinson's Disease
Treating Dystonia with DBS of the Globus Pallidus Interna
Treating Hyperkinetic Disorders

Chapter 13. Approach to Thalamic DBS
Regional Anatomy of the Ventral Intermediate Thalamus
Adverse Effects Resulting from the Position of the DBS Lead Relative to the Ventral
Effects of DBS on Speech and Swallowing
An Approach to Thalamic DBS for Tremor

Chapter 14. Algorithm for Selecting Electrode Configurations and
Stimulation Parameters

Chapter 15. Helpful Programming Hints
Use of Constant-Voltage DBS (to be discouraged)
Conduct a Monopolar Survey
Always Increase the Voltage to Clarify Any Side Effects
Check Therapeutic Impedances on Commercial IPGs
Confirm that the Parameters under Patient Control are within Safe Limits
Systematically Document all Clinical Responses to all DBS Stimulation Parameters and Electrode Configurations
Always Reset Counters and Trouble-Shoot Inconsistent Responses
Advise Patents, Family Members and Caregivers to Take Their DBS Controlling Devices with Them to Emergency Rooms or Doctor's Visits
Be Patient and Persistent!
When in Doubt, Turn the Pulse Generator Off and Wait
Trouble Shooting

Chapter 16. Oscillator Basics

Chapter 17. Discrete Neural Oscillators
Importance of Neural Oscillators in Nervous System Function
Continuous harmonic oscillators
Discrete Oscillators
Single Reentrant Discrete Oscillator
Interactions Among Discrete Oscillators
Discrete Neural Oscillators
Oscillators with multiple realistic neurons
The Systems (Discrete) Oscillators Theory

Appendix of Supplemental Material

Glossary

References

About the Author

Dr. Montgomery is a Movement Disorders Neurologist with a special interest in Parkinson's disease. He has conducted research in motor neurophysiology, particularly the role of the basal ganglia-thalamic-cortical system and the pathophysiology of Parkinson's disease for over 40 years. For the last 20 years, he has focused on deep brain stimulation in its clinical use and its underlying physiological mechanisms.

Reviews

"This work is a comprehensive treatise of many of the theoretical and practical aspects of the application of Deep Brain Stimulation (DBS). It spans the fundamental principles of electrical stimulation, electrophysiology and neuroanatomical considerations and outlines an approach to programming DBS at the most commonly utilized targets for Parkinson's disease. The book will be of value to practitioners who treat patients with DBS providing important key
background knowledge and a practical path towards tackling the challenges of choosing optimal stimulation parameters for these patients."
--Andres M. Lozano, MD, PhD, FRCSC, FRSC, FCAHS, Dan Family Professor and Chairman in Neurosurgery, University of Toronto, Toronto, Ontario, Canada
"As we become a bionic generation there is a large knowledge gap in programming deep brain stimulation devices. Dr. Montgomery's book addresses the principles of electrophysiology and the details of the pertinent brain regional anatomy. Dr. Montgomery helps the reader to identify and to utilize critical information to guide effective and efficient DBS programming. This is a must read, especially for new generation of health care professionals involved in the
care of DBS patients." --Michael S. Okun, MD, Adelaide Lackner Professor and Chairman of Neurology, University of Florida, Gainesville, FL