Table of Contents

PART I: THE MOLECULAR DESIGN OF LIFE Biochemistry: An Evolving Science Protein Composition and Structure Exploring Proteins and Proteomes DNA, RNA, and the Flow of Genetic Information Exploring Genes and Genomes Exploring Evolution and Bioinformatics Hemoglobin: Portrait of a Protein in Action Enzymes: Basic Concepts and Kinetics Catalytic Strategies Regulatory Strategies Carbohydrates Lipids and Cell Membranes Membrane Channels and Pumps Signal-Transduction Pathways PART II: TRANSDUCING AND STORING ENERGY Metabolism: Basic Concepts and Design Glycolysis and Gluconeogenesis The Citric Acid Cycle Oxidative Phosphorylation The Light Reactions of Photosynthesis The Calvin Cycle and the Pentose Phosphate Pathway Glycogen Metabolism Fatty Acid Metabolism Protein Turnover and Amino Acid Catabolism PART III: SYNTHESIZING THE MOLECULES OF LIFE The Biosynthesis of Amino Acids Nucleotide Biosynthesis The Biosynthesis of Membrane Lipids and Steroids The Integration of Metabolism DNA Replication, Repair, and Recombination RNA Synthesis and Processing Protein Synthesis The Control of Gene Expression in Prokaryotes The Control of Gene Expression in Eukaryotes PART IV: RESPONDING TO ENVIRONMENTAL CHANGES Sensory Systems The Immune System Molecular Motors Drug Development

About the Author

JEREMY M. BERG was Professor and Director of the Department of Biophysics and Biophysical Chemistry at Johns Hopkins University School of Medicine, USA, where he remained until 2003. He then became Director of the National Institute of General Medical Sciences at the National Institutes of Health. He is an elected Fellow of the American Association for the Advancement of Science. He is the recipient of the American Chemical Society Award in Pure Chemistry (1994), the Eli Lilly Award for Fundamental Research in Biological Chemistry (1995), the Maryland Outstanding Young Scientist of the Year (1995), the Harrison Howe Award (1997), the Distinguished Service Award from the Biophysical Society (2009), and the Howard K. Schachman Public Service Award from the American Society for Biochemistry and Molecular Biology (2011). He also won numerous teaching awards including the W. Barry Wood Teaching Award (selected by medical students), the Graduate Student Teaching Award, and the Professor's Teaching Award for the Preclinical Sciences. JOHN L. TYMOCZKO is Towsley Professor of Biology at Carleton College, USA, where he has taught since 1976. He currently teaches Biochemistry, Biochemistry Laboratory, Oncogenes and the Molecular Biology of Cancer, and Exercise Biochemistry and co-teaches an introductory course, Energy Flow in Biological Systems. The focus of his research has been on steroid receptors, ribonucleoprotein particles, and proteolytic processing enzymes. LUBERT STRYER is Winzer Professor of Cell Biology, Emeritus, in the School of Medicine and Professor of Neurobiology, Emeritus, at Stanford University, USA, where he has been on the faculty since 1976. Professor Stryer has received many awards for his research on the interplay of light and life, including the Eli Lilly Award for Fundamental Research in Biological Chemistry and the Distinguished Inventors Award of the Intellectual Property Owners' Association. He was elected to the National Academy of Sciences in 1984. He currently chairs the Scientific Advisory Boards of two biotechnology companies - Affymax, Inc., and Senomyx, Inc. - and serves on the Board of the McKnight Endowment Fund for Neuroscience. The publication of his first edition of Biochemistry in 1975 transformed the teaching of biochemistry. GREGORY J. GATTO, Jr. received his A.B. degree in Chemistry from Princeton University, USA, where he worked with Martin F. Semmelhack and was awarded the Everett S. Wallis Prize in Organic Chemistry. In 2003, he received his M.D. and Ph.D. degrees from the John Hopkins University School of Medicine, USA, where he studied the structural biology of peroxisomal targetting signal recognition with Jeremy M. Berg and received the Michael A. Shanoff Young Investigator Research Award. He then completed a postdoctoral fellowship in 2006 with Christopher T. Walsh at Harvard Medical School, where he studied the biosynthesis of the macrolide immunosuppressants. He is currently an Investigator in the Heart Failure Discovery Performance Unit at GlaxoSmithKline Pharmaceuticals (gsk).