Table of Contents

Contributors
Consultants to the Editors
Preface
Preface to the First Edition
SECTION I: GENERAL PRINCIPLES
1. Drug Invention and the Pharmaceutical Industry, Suzanne M. Rivera and Alfred Goodman Gilman
2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination, Iain L. O. Buxton and Leslie Z. Benet
3. Pharmacodynamics: Molecular Mechanisms of Drug Action, Donald K. Blumenthal and James C. Garrison
4. Drug Toxicity and Poisoning, Kevin C. Osterhoudt and Trevor M. Penning
5. Membrane Transporters and Drug Response, Kathleen M. Giacomini and Yuichi Sugiyama
6. Drug Metabolism, Frank J. Gonzalez, Michael Coughtrie, and Robert H. Tukey
7. Pharmacogenetics, Mary V. Relling and Kathleen M. Giacomini
SECTION II: NEUROPHARMACOLOGY
8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems, Thomas C. Westfall and David P. Westfall
9. Muscarinic Receptor Agonists, Joan Heller Brown and Nora Laiken
10. Anticholinesterase Agents, Palmer Taylor
11. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia, Ryan E. Hibbs and Alexander C. Zambon
12. Adrenergic Agonists and Antagonists, Thomas C. Westfall and David P. Westfall
13. 5-Hydroxytryptamine (Serotonin) and Dopamine, Elaine Sanders-Bush and Lisa Hazelwood
14. Neurotransmission and the Central Nervous System, Perry B. Molinoff
15. Drug Therapy of Depression and Anxiety Disorders, James M. O'Donnell and Richard C. Shelton
16. Pharmacotherapy of Psychosis and Mania, Jonathan M. Meyer
17. Hypnotics and Sedatives, S. John Mihic and r. Adron Harris
18. Opioids, Analgesia, and Pain Management, Tony L. Yaksh and Mark S. Wallace
19. General Anesthetics and Therapeutic Gases, Piyush M. Patel, Hemal H. Patel, and David M. Roth
20. Local Anesthetics, William A. Catteral nad Kenneteh Mackie
21. Pharmacotherapy of the Epilepsies, James O. McNamara
22. Treatment of Central Nervous System Degenerative Disorders, David G. Standaert and Erik D. Roberson
23. Ethanol and Methanol, Marc A. Schuckit
24. Drug Addition, Charles P. O'Brien
SECTION III: MODULATION OF CARDIOVASCULAR FUNCTION
25. Regulation of Renal Function and Vascular Volume, Robert F. Reilly and Edwin K. Jackson
26. Renin and Angiotensin, Randa Hilal-Dandan
27. Treatment of Myocardial Ischemia and Hypertension, Thomas Michel and Brian B. Hoffman
28. Pharmacotherapy of Congestive Heart Failure, Bradley A. Maron and Thomas P. Rocco
29. Anti-Arrhythmic Drugs, Kevin J. Sampson and Robert S. Kass
30. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs, Jeffrey I. Weitz
31. Drug Therapy for Hypercholesterolemia and Dyslipiedmia, Thomas P. Bersot
SECTION IV: INFLAMMATION, IMMUNOMODULATION, AND HEMATOPOIESIS
32. Histamine, Bradykinin, and Their Antagonists, Randal A. Skidgel, Allen P. Kaplan, and Ervin G. Erdös
33. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor, Emer M. Smyth, Tilo Grosser, and Garret A. Fitzgerald
34. Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacology of Gout, Tilo Grosser, Emer Smyth, and Garret A. FitzGerald
35. Immunosupressants, Tolerogens, and Immunostimulants, Alan M. Krensky, William M. Bennett, and Flavio Vincenti
36. Pulmonary Pharmacology, Peter J. Barnes
37. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins, Kenneth Kaushansky and Thomas J. Kipps
SECTION V: HORMONES AND HORMONE ANTAGONISTS
38. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis, Keith L. Parker and Bernard P. Schimmer
39. Thyroid and Anti-Thyroid Drugs, Gregory A. Brent and Ronald J. Koenig
40. Estrogens and Progestins, Ellis R. Levin and Stephen R. Hammes
41. Androgens, Peter J. Snyder
42. ACTH, Adrenal Steroids, and Pharmacology of the Adrenal Cortex, Bernard P. Schimmer and John W. Funder
43. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia, Alvin C. Powers and David D'Alessio
44. Agents Affecting Mineral Ion Homeostatis and Bone Turnover, Peter A. Friedman
SECTION VI: DRUGS AFFECTING GASTROINTESTINAL FUNCTION
45. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease, John L. Wallace and Keith A. Sharkey
46. Treatment of Disorders of Bowel Motility and Water Flux: Anti-Emetics; Agents Used in Biliary and Pancreative Disease, Keith A. Sharkey and John L. Wallace
47. Pharmacotherapy of Inflammatory Bowel Disease, John L. Wallace and Keith A. Sharkey
SECTION VII: CHEMOTHERAPY OF MICROBIAL DISEASES
48. General Principles of Antimicrobial Therapy, Tawanda Gumbo
49. Chemotherapy of Malaria, Joseph M. Vinetz, Jerome Clain, Viengngeun Bounkeua, Richard T. Eastman, and David Fidock
50. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections, Margaret A. Phillips, Samuel L. Stanley, Jr.
51. Chemotherapy of Helminth Infections, James McCarthy, Alex Loukas, and Peter J. Hotez
52. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections, William A. Petri, Jr.
53. Penicillins, Cephalosporins, and Other ß-Lactam Antibiotics, William A. Petri, Jr.
54. Aminoglycosides, Conan MacDougall and Henry F. Chambers
55. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents, Conan MacDougall and Henry F. Chambers
56. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy, Tawanda Gumbo
57. Antifungal Agents, John E. Bennett
58. Antiviral Agents (Nonretroviral), Edward P. Acosta and Charles Flexner
59. Antiretroviral Agents and Treatment of HIV Infection, Charles Flexner
SECTION VIII: CHEMOTHERAPY OF NEOPLASTIC DISEASES
60. General Principles of Cancer Chemotherapy, Bruce A. Chabner
61. Cytotoxic Agents, Bruce A. Chabner, Joseph Bertino, James Cleary, Taylor Ortiz, Andrew Lane, Jeffrey G. Supko, and David Ryan
62. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines, Bruce A. Chabner, Jeffrey Barnes, Joel Neal, Erin Olson, Hamza Mujagic, Lecia Sequist, Wynham Wilson, Dan L. Longo, Constantine Mitsiades, and Paul Richardson
63. Natural Products in Cancer Chemotherapy: Hormones and Related Agents, Beverly Moy, Paul Goss, Richard J. Lee, and Matthew Smith
SECTION IX: OPHTHALMOLOGY
64. Ocular Pharmacology, Jeffrey D. Henderer and Christopher J. Rapuano
65. Dermatological Pharmacology, Craig Burkhart, Dean Morrell, and Lowell Goldsmith
66. Contraception and Pharmacotherapy of Obstetrical and Gynecological Disorders, Bernard P. Schimmer and Keith L. Parker
67. Environmental Toxicology: Carcinogens and Heavy Metals, Michael C. Byrns and Trevor M. Penning
APPENDICES
I. Principles of Prescription Order Writing and Patient Compliance, Iain L.O. Buxton
II. Design and Optimization of Dosage Regimens: Pharmacokinetic Data, Kenneth E. Thummel, Danny D. Shen, and Nina Isoherranen
Index

About the Author

Laurence L. Brunton, PhD
Professor of Pharmacology and Medicine
University of California, San DiegoLaurence Brunton trained under Alfred Goodman-Gilman and is nationally recognized for his expertise in cell signaling and cardivacular pharmacology. He has published more than 200 original research papers. Bruce Chabner, MD
Professor of Medicine
Harvard Medical School
Director, Massachusetts General Hospital Cancer Center
Boston, MA