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Total Intravenous Anesthesia and Target Controlled Infusions


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CONTENTS PART 1. INTRODUCTION/BACKGROUND 1. When and How Did It All Begin? A Brief History of Intravenous Anesthesia

John Sear

2. The Development and Regulation of Commercial Devices for Target - Controlled Drug Infusion

John B Glen

3. The Memory Labyrinth: systems, processes and boundaries Robert A. Veselis 4. Consciousness and Anaesthesia

Ram Adapa

5. Mechanisms of Intravenous Anaesthetic Action Hugh C. Hemmings Jr and Karl F. Herold PART 2. PRINCIPLES OF PHARMACOLOGICAL MODELING 6. Basic Pharmacology: Kinetics and Dynamics for Dummies

Johan Raeder

7. Pharmacokinetic-Pharmacodynamic Modelling of Anesthetic Drugs

Johannes Hans Proost

8. Principles of Target Controlled Infusions

Steven L. Shafer

9. Performance of Target-Controlled Infusion Systems

Matthew TV Chan

10. How to Select a PK/PD Model

Kenichi Masui


Douglas J. Eleveld

12. Etomidate and Etomidate Analogues: Molecular Pharmacology and Behavioral Actions

Douglas E. Raines

13. Dexmedetomidine: The Science and Clinical Aspects in Adults and Children

Mohamed Mahmoud

14. Clinical Effects and Applications of Ketamine

Mark G. Roback

15. Neuromuscular Blocking Drugs: Pharmacology, Physiology and Clinical Aspects

Claude Meistelman

16. New and Upcoming Drugs: Intravenous Anesthetic Agents

John William Sear

17. Drug Interactions in Anesthesia

Jaap Vuyk


18. Pumps Pitfalls and Practicalities

Frank Engbers

19. EEG Monitoring of Depth of Anesthesia

Michael Sury

20. Monitoring the analgesic component of anesthesia

Isabelle Constant<

21. Intravenous Drugs for Sedation: Target Controlled, Patient Controlled, and Patient Maintained Delivery

Keith J Anderson and Gavin NC Kenny

22. Pediatric TIVA/TCI: Case Presentations and Discussion Vivian Man-ying Yuen 23. TCI/TIVA Adult Case Studies

Nicholas Sutcliffe

< PART 5. SPECIAL POPULATIONS AND PROCEDURES 24. Intravenous Anesthesia in Obese Patients

Pablo Sepulveda and Ignacio Cortinez

25. Pharmacokinetics and Dynamics on the Pediatric Population

Brian J. Anderson

26. Clinical Pharmacology of Intravenous Sedation in Children

Oliver Bagshaw

27. Sedation of the Critically Ill Child

Arno Brouwers, Sanne Vaassen, Gijs D Vos, Jan NM Schieveld, and Piet L Leroy

28. TCI & TIVA for Neurosurgery: Considerations and Techniques Massimo Lamperti and Fazil Ashiq 29. TCI in Special Patients Groups: The Elderly and Obese Frederique S Servin 30. TIVA for Cardiac Surgery Stefan Schraag 31. TIVA/TCI in Veterinary Practice Thierry Beths PART 6. OUTCOME, EDUCATION, SAFETY, AND THE FUTURE 32. Advantages, Disadvantages, and Risks of TIVA/TCI Ken B Johnson 33. Economics of TIVA Jane Montgomery and Mary Stocker 34. Teaching TCI with Human Patient Simulators Wolfgang Heinrichs 35. Closed-Loop or Automated Titration of Intravenous Anesthesia: Background, Science and Clinical Impact Ngai Liu 36. Health Care Technology, the Human-Machine Interface, and Patient Safety During Intravenous Anesthesia Craig S. Webster 37. Can IV Sedatives Affect Outcome? Christopher G. Hughes, Christina J. Hayhurst, and Pratik P. Pandharipande 38. The Benefit and Future of Pharmacogenetics Janko Samardzic, Dubravka Svob Strac, and John N. van den Anker 39. Lessons from drug interaction displays Ross Kennedy 40. The Role of Intravenous Agents in Delirium Claudia Spies, Susanne Koch, Alissa Wolf, Rudolf Moergeli, and Bjoern Weiss 41. Perioperative Cardioprotective Strategies in Noncardiac Surgery Stefan De Hert 42. Opioid Induced Hyperalgesia after Surgery: Clinical Relevance Dr. Philippe Richebe 43. Memory, Awareness and Intravenous Anaesthetics Michael Wang 44. Awareness and Dreaming During TIVA Kate Leslie 45. Apoptosis and Neurocognitive Effects of Intravenous Anesthetics Sulipicio Soriano and Laszlo Vutskits Epilogues

About the Author

Anthony R. Absalom, MBChB, FRCA, MD
Professor of Anesthesiology, The University Medical Center Groningen, University of Groningen, The NetherlandsDr. Absalom is internationally recognized as a leading expert on anaesthetic pharmacology and total intravenous anesthesia. He currently serves as Editor of the British Journal of Anaesthesia and is a former editorial board member of Trends in Anaesthesia and Critical Care. He is currently president of the Society for Intravenous Anesthesia (UK). In the past he has served as a board member of ISAP (International Society for Intravenous Anaesthesia) and as vice-president of the World Society of Intravenous Anaesthesia.
Keira P. Mason, MD is an Associate Professor of Anaesthesia (Radiology) at Harvard Medical School, , Boston Children's Hospital, Boston, MA. Dr. Mason is a Springer author. We recently published the expanded Second Edition of her critically and globally acclaimed book, Pediatric Sedation Outside of the Operating Room, 2nd ed, Mason, ed., (2015). During 1998-2014, Dr. Mason was Director of Radiology Anesthesia and Sedation at Boston Children's Hospital, where she developed a sedation and anesthesia program that continues to be nationally and internationally recognized. She is considered a pioneer of innovative and safe sedation protocols which have been adopted worldwide. Dr. Mason is past- Vice President of the World Society of Intravenous Anesthesia (Founding Board Member), and a frequent invited lecturer to national and international conferences, including Society of Interventional Radiology, American Society of Anesthesiologists, Radiological Society of North America, International Dental Congress on Anesthesia, Sedation, and Pain Control, Society of Ambulatory Anesthesia, Asian and Oceanic Society of Regional Anesthesia, Japanese Society for Intravenous Anesthesia, International Association of Pediatric Dentistry, All-African Anaesthesia Congress, Asian Society of Paediatric Anesthesiologists, and many others. She is the Course Director for Pediatric Sedation Outside the Operating Room, a conference she initiated through Harvard Medical School and is an active member of the American Society of Anesthesiologists (ASA) Committees. She has authored many book chapters. As a Principal Investigator of numerous studies, some which required approval of the Food and Drug Administration (FDA), she has numerous publications. Dr. Mason continues to serve on expert panels for the FDA. She is on the Editorial Board of the British Journal of Anaesthesia.


"Total Intravenous Anesthesia and Target Controlled Infusions is a traditional textbook that bills itself as a comprehensive guide to the subject. ... this textbook form part of the reference collection of all anesthetic department libraries. It is a high-quality volume, well bound with excellent color illustrations, printed on thick paper, and is a worthwhile purchase. ... Those that take the time to read a good portion of it will be richly rewarded in their increased understanding of TIVA." (Timothy G. Short and Gerard Willemsen, Anestesia & Analgesia, Vol. 125 (1), January, 2018)

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