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Thymosins in Health and Disease
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Part I: Thymosins: Structure and Design, Isoforms, Genomics, Multifunctionality:. 1. Contributions from all over: widely-distributed residues in thymosin beta4 affect the kinetics and stability of actin binding: Daniel Safer. 2. The beta-thymosin engima: Helen L. Yin. 3. The interaction of the C-terminal half of thymosin beta4 with actin: Robert C. Robinson. 4. Evolution of the actin-sequestering function in beta-thymosins and modular beta-thymosin repeat proteins: Marie-France Carlier. 5. Thymosin beta4: actin regulation and more: Elena G. Yarmola. 6. The thymosin fold among cytoskeletal proteins: multifunctionality and structure: Roberto Dominguez. Part II: Wound Healing, Inflammation, and Fibrosis:. 7. Unexpected findings in mice overexpressing thymosin beta4: Hynda Kleinman. 8. Adhesive and proteolytic phenotype of migrating endothelial cells induced by thymosin beta4: Czeslow S. Cierniewski. 9. Thymosin beta4 and the eye: I can see clearly now the pain is gone: Gabe Sosne. 10. In vivo detection of thymosins via mass spectrometric proteomics an ultrafiltration sampling: the role of in vivo secreted-thymosins in skin biology: Chun-Ming (Eric) Huang. 11. Airway disease and sputum: the role of DNA and actin polymers: Bruce Rubin. 12. Liver cirrhosis: a reversible process?: Marcos Rojkind. Part III: Cardiovascular Protection, Neuroplasticity, Stem Cells Repair, and Regeneration:. 13. Cardiac protection and angiogenesis induced by thymosin beta4: Deepak Srivistava. 14. Thymosin beta4: the potential for neovascular therapy in the injured adult heart: Paul R. Riley. 15. Post-translational regulation of beta-thymosin repeat protein: contribution to intrinsic cellular excitability: Terry Crow. 16. Prothymosin alpha in relation to chromatin decondensation and the role of beta-thymosins in synaptic plasticity: Jaime Gomez-Marquez. 17. Thymosin beta4 as a protective agent in the nervous system and the effects of its overexpression/ablation in neuronal and tumoral stem cells: Daniela Merlo. 18. Emerging multipotent roles of thymosin beta in the development and regeneration of the nervous system: Woong Sun. Part IV: Immunopharmocology, Pharmacogenomics, and Combination Therapies:. 19. Thymosin alpha 1 from bench to bedside: Enrico Garaci. 20. Immunopharmacology of thymosin alpha1: Paul Naylor. 21. IRX-3: A novel biologic to reverse immune suppression: John Hadden. 22. Clinical experiences with thimosins in influenza: William Ershler. 23. IFN-alpha and novel strategies of combination therapy of cancer: Filippo Belardelli. 24. Combination Trials with thymosin alpha 1 in hepatitis B and C: Guido Rasi. Part V: Molecular Markers, Signaling, and Diagnostics for Cancer and Infectious Diseases:. 25. Thymosin alpha1 as a chemopreventive agent in breast and lung cancer: Terry Moody. 26. Characterization of a peptide component of thymosin fraction-5 manifesting cytostatic properties in HL-60 human promyelocytic leukemia cells: Brian Spangelo. 27. Cellular distribution of thymosin beta4 in tumors: Lars-Inge Larsson. 28. Anti-HIV-1 activity of both thymosin beta4 and prothymosin alpha: Arevik Mosoian. 29. Thymosin alpha1: an endogenous regulator of inflammation and tolerance in antimicrobial immunity and autoimmunity: Luigina Romani. 30. Activation of signal pathways by thymosin alpha1: Wen-ming Chu. Part VI: Clinical Applications of Thymosin a1 and Thymosin b4:. 31. Issues in pharmaceutical development of thymosin alpha1 from preclinical studies through marketing: Cynthia Tuthill. 32. Clinical experience with the role of thymosin alpha 1 in hepatitis B and C: Vinod K. Rustgi. 33. European Phase III, Randomized, Double Blind, Multicenter Study of Triple Therapy with Thymosin alpha 1 plus Pegylated Interferon alpha-2a plus Ribavirin in Non Responder Patients with Chronic Hepatitis C. Study Design and Preliminary Safety Data: Mario Rizzetto. 34. Development of Thymosin beta4 for Ischemic Heart Disease: David Crockford. 35. beta-thymosin and venous ulcers: clinical remarks on a European perspective, randomised study on safety, tolerabiilty, and enhancement on healing: Giorgio Guarnera. 36. Myocardial infarction markers in patients with acute limb ischaemia: Piotr Gutowski. 37. Thymosin beta4 and epidermolysis bullosa: Jo-David Fine. 38. Chronic Cutaneous Wound Treatment: Pressure Ulcers - A Role for Thymosin beta4: Mike Godschalk

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