Thoroughly discusses the challenges and future prospects of designing and fabricating new biological components and systems for pathway, whole cell, and multi-cell applications
Introduction Section I. Synthesis and engineering tools in synthetic biology Chapter 1. DNA synthesis Chapter 2. Protein engineering Chapter 3. Pathway engineering Chapter 4. Biological standardization Section II. Computational and theoretical tools in synthetic biology Chapter 5. Biocomplexity issues in synthetic biology Chapter 6. Computational protein design Chapter 7. Computer-Aided Design in Synthetic Biology Chapter 8. Computational tools for strain design Sections III. Applications in synthetic biology Chapter 9. Pathway/network level: design and applications of therapeutic genetic circuits Chapter 10. Pathway/network level: production of drugs Chapter 11. Pathway/network level: synthesis of new fuels Chapter 12. Organism level: genome assembly Chapter 13. Multi-cell level: synthetic prey-predator system Section IV. Future prospects Chapter 14. Design of artificial cells Chapter 15. Cell-free synthetic biology Chapter 16. Artificial photosynthesis Chapter 17. Engineering synthetic ecosystems
Dr. Huimin Zhao is the Centennial Endowed Chair Professor of chemical and biomolecular engineering, and professor of chemistry, biochemistry, biophysics, and bioengineering at the University of Illinois at Urbana-Champaign (UIUC). He received his B.S. degree in Biology from the University of Science and Technology of China in 1992 and his Ph.D. degree in Chemistry from the California Institute of Technology in 1998 under the guidance of Dr. Frances Arnold. Prior to joining UIUC in 2000, he was a project leader at the Industrial Biotechnology Laboratory of the Dow Chemical Company. He was promoted to full professor in 2008. Dr. Zhao has authored and co-authored 150 research articles and 20 issued and pending patent applications with several being licensed by industry. In addition, he has given plenary, keynote or invited lectures in more than 170 international meetings and institutions. Eight of his former graduate students and postdocs became professors in the US and other countries. Dr. Zhao received numerous research and teaching awards and honors, including Guggenheim Fellowship (2012), Fellow of the American Association for the Advancement of Science (AAAS) (2010), Fellow of the American Institute of Medical and Biological Engineering (AIMBE) (2009), American Institute of Chemical Engineers (AIChE) Food, Pharmaceutical, and Bioengineering Division Plenary Award Lecturer (2009), the American Chemical Society (ACS) Division of Biochemical Technology Young Investigator Award (2008), Outstanding Overseas Young Chinese Scholars Award (2007), DuPont Young Professor Award (2005), National Science Foundation CAREER Award (2004), Dow Chemical Special Recognition Award (1999), Xerox Award for Faculty Research from UIUC College of Engineering (2005), Petit Scholar from UIUC College of Liberal Arts and Sciences (2006), and University Scholar from UIUC (2007). Dr. Zhao served as a consultant for over 10 companies such as Pfizer, Maxygen, BP, Gevo, and zuChem, and a Scientific Advisory Board member of Gevo and Myriant Technologies. He is also an advisor to the Department of Energy's Biological and Environmental Research program. Dr. Zhao is an Associate Editor of ACS Catalysis and an editor of ACS Synthetic Biology, Journal of Industrial Microbiology and Biotechnology, and Scientific Reports (Nature). His primary research interests are in the development and applications of synthetic biology tools to address society's most daunting challenges in human health and energy, and in the fundamental aspects of enzyme catalysis, cell metabolism, and gene regulation.
"Chemical, biological, and biochemical engineers describe tools and methodologies developed for engineering biological systems at a wide range of levels, including molecular, pathway, network, whole cell, and multi-cell. They also explore practical applications of synthetic biology, a branch of genetic engineering that incorporates systems biology."--Reference and Research Book News, August 2013 "The proposed book is exclusively focused on synthetic biology. It brings together the thought leaders in this emerging field, giving expert accounts and their opinions of special topics in synthetic biology. This might be the first dedicated, edited book for synthetic biology."--Dr. Qing Lin, State University of New York at Buffalo, Buffalo, NY, USA