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Survivors of Childhood and Adolescent Cancer

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Table of Contents

Overview.- Algorithms of Late Effects by Disease.- Facilitating Assessment of Late Effects by Organ System.- Pediatric Growth and Development: Impact on Vulnerability to Normal Tissue Damage from Cancer Therapy.- Central Nervous System Effects.- Neuroendocrine Complications of Cancer Therapy.- Ocular Complications due to Cancer Treatment.- Head and Neck.- Adverse Effects of Cancer Treatment on Hearing.- The Thyroid Gland.- Cardiovascular Effects of Cancer Therapy.- Pulmonary Effects of Antineoplastic Therapy.- Late Gastrointestinal and Hepatic Effects.- The Ovary.- The Testes.- Genitourinary.- Musculoskeletal, Integument.- Breast.- Hematopoietic Stem Cell Transplantation.- Second Malignancies Following Treatment for Childhood Cancer.- Psychological Aspects of Long-Term Survivorship.- Legal Issues.- Methodological Issues in the Study of Survivors of Childhood Cancer.- Survivorship Transitions following Childhood and Adolescent Cancer.- Health Maintenance and Promotion.

About the Author

Cindy L. Schwartz, MD, MPH is Division Head and Chair of Pediatrics ad interim at MD Anderson Cancer Center, Houston, TX. She is the Edgar Lewis Curtis, Savilla Elizabeth Curtis and Eleanor Lewis Curtis Distinguished Professor in Pediatric Cancer. Previously she was the Director of Pediatric Hematology-Oncology at Hasbro Children's Hospital, Brown University, Providence, Rhode Island, Associate Director of Clinical Programs in Pediatric Oncology at Johns Hopkins and Interim Director of Pediatric Hematology Oncology at the University of Rochester. She has developed and led programs for pediatric cancer survivors at these institutions. Professor Schwartz was the Chair of the Childrens and Pediatric Oncology Groups' Hodgkin Lymphoma Committees from 1999-2011 and has led many national clinical trials in Hodgkin Lymphoma and osteosarcoma. She has been named in America's Top Doctors for each of the past 14 years. She has served on the editorial boards of the Journal of Clinical Oncology and Pediatric Blood and Cancer and is a reviewer for many other journals. She has been a member of National Cancer Institute advisory committees and has been Chair of the DSMB of the NANT (Novel Approaches to Neuroblastoma Therapy). She is author or co-author of more than 70 original publications in peer-reviewed journals as well as many book chapters.Louis S. Constine, MD, FASTRO is Professor of Radiation Oncology and Pediatrics and Vice Chair of the Department of Radiation Oncology, and was awarded fellowship in his professional society, The American Society of Radiation Oncology. After graduating from Stanford University, and The Johns Hopkins University School of Medicine, he trained in pediatrics, pediatric oncology and radiation oncology, and has board certification in these areas. His clinical and scientific expertise is in lymphomas, sarcomas, all pediatric malignancies, and the broad area of Survivorship that includes the acute

and chronic effects of chemotherapy and radiation therapy on normal tissues. He is the Director of the University of Rochester Medical Center (Judy DiMarzo) Survivorship Program, and the Radiation Chair of the Lymphoma Committee in the Southwest Oncology Group. He is on the core committees for the Children's Oncology Group Survivorship Guidelines, the International Survivorship Harmonization Guidelines, the American Society of Clinical Oncology Survivorship Advisory Group, and he leads the Pediatric Quantitative Analysis of Normal Tissue Effects in the Clinic ASTRO/AAPM initiative. He serves on the Children's Oncology Group Late Effects Steering Committee, and is senior advisor for the Children's Oncology Group Hodgkin Lymphoma Committee. He is a co-investigator on an ROI evaluating long-term toxicities of cancer therapy. He just completed work on a four-person United Nations task force for an initiative on the adverse effects of radiation on children; he discussed their 240 page document at the UN international headquarters (Vienna) in 5/12 and again in 5/13. Other international efforts now include his core membership on an International Atomic Energy Agency initiative to develop pediatric radiation oncology in low-income countries that met in Vienna in 6/13. Additional activities included membership on task forces for the American Heart Association on cardiotoxicity, and the National Council on Radiation Protection Scientific Committee on "Second Primary Cancers and Cardiovascular Disease after Radiation Therapy." He is recipient of an NIH merit award in 2010, the Jacob Gitelman Award from Cancer Action, the "Make a Difference" Award from Melissa's Legacy, and the Teddy award from Camp Good Days and Special Times. He is included in the America's Top Doctors for Cancer. He is a member of numerous societies including The American Society of Radiation Oncology, the Radiation Research Society, the American Society of Clinical Oncology, and the American Society of Hematology. He has authored (co-authored) more than 50 book chapters, eight books and 150 original and invited reports. His professional life is guided by his words: For the survivor of cancer, the world is full and each day is a celebration -- for the physician, each patient is an inspiration -- for the person fighting cancer, each day is precious and must be faced with courage.Wendy Hobbie, MSN, PNP-BC, FAAN is the Associate Director, Cancer Survivorship Program at The Children's Hospital of Philadelphia. Ms Hobbie was part of the original team at CHOP that developed the one of the first comprehensive survivorship program in the country in 1983. She has championed the role development of nurse practitioners working with this population. She has consulted both nationally and internationally on program development for pediatric cancer survivors. Ms Hobbie has co-authored over 70 articles and chapters along with co-author/editor of two books, both in their 3rd edition that have served to educate countless parents, survivors and health care providers on the care of children who have survived cancer. Ms. Hobbie's research has been focused on improving the quality of life of cancer survivors and their families.


"This volume reviews systematically in 24 chapters the sequelae of cancer therapy on all body systems and organs. ... Written by multidisciplinary teams it has many colored photos and tables and references. A textbook highly recommended to pediatric oncologists, endocrinologists, roentgenologists and health teams who care for children after cancer therapy." (Zvi Laron, Pediatric Endocrinology Reviews, Vol. 13 (4), June, 2016)
"This book is designed to bring attention to the long-term complications induced by cancer treatments of children. ... The audience includes healthcare professionals in the many disciplines who care for oncology patients -- physicians, nurses, and physical therapy, speech therapy, occupational therapy, and mental health providers. ... There are many high quality pictures and graphs throughout the book." (Melissa Mason, Doody's Book Reviews, February, 2016)

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