Science and Development of Muscle Hypertrophy


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Table of Contents

Chapter 1. Hypertrophy-Related Responses and Adaptations to Exercise Stress
Neuromuscular System
Endocrine, Paracrine, and Autocrine Systems

Chapter 2. Mechanisms of Hypertrophy
Mechanical Tension
Metabolic Stress
Muscle Damage

Chapter 3. The Measurement of Muscle Hypertrophy
Indirect Measures
Site-Specific Measures

Chapter 4. Role of Resistance Training Variables in Hypertrophy
Exercise Selection
Type of Muscle Action
Rest Interval Length
Repetition Duration
Exercise Order
Range of Motion
Intensity of Effort

Chapter 5. Advanced Training Practices
Loaded Stretch Training
Intraset Rest Training
Drop Sets
Supersets and Pre-exhaustion
Eccentric Overload Training

Chapter 6. Role of Aerobic Training in Hypertrophy
Hypertrophic Effects From Aerobic-Only Training
Concurrent Training

Chapter 7. Factors in Maximal Hypertrophic Development
Training Status

Chapter 8. Program Design for Maximal Hypertrophy
Exercise Selection Strategies

Chapter 9. Nutrition for Hypertrophy
Energy Balance
Macronutrient Intake
Feeding Frequency
Nutrient Timing

About the Author

Brad Schoenfeld, PhD, CSCS,*D, CSPS,*D, NSCA-CPT,*D, FNSCA, is internationally regarded as one of the foremost authorities on muscle hypertrophy. The 2011 National Strength and Conditioning Association (NSCA) Personal Trainer of the Year is a lifetime drug-free bodybuilder who has won multiple natural bodybuilding titles. As a personal trainer, he has worked with numerous elite-level physique athletes, including many top pros.

Schoenfeld is the recipient of the 2016 Dwight D. Eisenhower Fitness Award, which is presented by the United States Sports Academy for outstanding achievement in fitness and contributions to the growth and development of sport fitness through outstanding leadership activity. He was also the 2018 cowinner of the NSCA Outstanding Young Investigator award. He is the author of multiple fitness books, including The M.A.X. Muscle Plan and Strong & Sculpted. He has been published or featured in virtually every major fitness magazine and has appeared on hundreds of television shows and radio programs across the United States. Currently, he writes the "Ask the Muscle Doc" column for

Schoenfeld earned his PhD in health promotion and wellness at Rocky Mountain University, where his research focused on elucidating the mechanisms of muscle hypertrophy and their application to resistance training. He has published more than 200 peer-reviewed scientific papers and serves on the editorial advisory boards for several journals, including the Journal of Strength and Conditioning Research and the Journal of the International Society of Sports Nutrition.

Schoenfeld is an associate professor of exercise science at Lehman College in the Bronx, New York, and is director of the graduate program in human performance and fitness. He also serves as a sports nutrition consultant for the New Jersey Devils hockey organization.

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