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Resistance to Photodynamic Therapy in Cancer
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This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.
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Table of Contents

Introduction 1. Basic and Clinical Aspects of photodynamic Therapy Valentina Rapozzi and Giulio Jori Mechanistic Aspects Involved in Resistance to PDT 2. Mechanisms of Resistance to Photodynamic Therapy Adriana G. Casas, Christian Perotti, Gabriela Di Venosa and Alicira Batlle 3. Tumor Vascular Microenvironment Determines responsiveness to Photodynamic Therapy Shannon M. Gallagher-Colombo, Jarod C. Finlay and Theresa M. Busch 4. Autophagy Pathways Activated in Response to PDT Contribute to Cell Resistance Against ROS Damage Abhishek D. Garg and Patrizia Agostinis 5. Methods to isolate the Resistant Cells to Photodynamic Therapy Alicia Zamarron, Sara E. Lucena, Nerea Salazar, Pedro Jaen, Salvador Gonzalez, Yolanda Gilaberte and Angeles Juarranz Specific Strategies to Sensitize Tumor Cells to PDT 6. GRP78-Targeting Subtilase Cytotoxin Sensitizes Cancer Cells to Photodynamic Therapy Malgorzata Firczuk, Magdalena Gabrysiak and Jakub Golab 7. Optimization of Photodynamic Therapy Response by Survivin Gene Knockdown in Human Metastatic Breast Cancer Viviana A. Rivarola and Ingrid Sol Cogno 8. Cellular Targets and Molecular Responses Associated with Photodynamic Therapy Marian Luna, Angela Ferrario, Natalie Rucker, Emma Balouzian, Sam Wong, Sophie Mansfield and Charles J. Gomer Approaches to Reduce the Multi-Drug Resistance of Tumor Cells by PDT 9. The Use of Nanoparticle-Delivered Photosensitizers Can Overcome the Development of Resistance to PDT in Tumors Magali Toussaint, Muriel Barberi-Heyob, Sophie Pinel and Celine Frochot 10. Mechanisms of tumor cells resistance to ALA/PDT Zvi Malik, Abraham Nudelman and Benjamin Ehrenberg 11. Overcoming the Resistance of Meolanoma to Photodynamic Therapy Sulbha K. Sharma, Ying-Ying Huang and Michael R.Hamblin

About the Author

Giulio Jori is Professor of Biophysics at the University of Padova, Italy. He has been a founding member and President of the European Society for Photobiology. His research interests are focused on basic mechanisms of photodynamic action at a cellular and tissue level, as well as investigations concerning the application of photodynamic therapy for the treatment of tumours and microbial infections. Dr. Jori is Editor-in-chief of Journal of Photochemistry and Photobiology and he was also chairman of the ownership board of the journal Photochemical and Photobiological Sciences. He has been the chief organizer of nine International Symposia on Photodynamic Therapy and Photodiagnosis in Clinical Practice. In addition, he has received an award for excellence in research from the European Society for Photobiology. Valentina Rapozzi is a Researcher at the University of Udine, Italy. Dr. Rapozzi's research is focused on the antitumoral molecular pathways in photodynamic therapy. She is a member of the European Society for Photobiology, and a member of the Council of the Italian Society of Photobiology.

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