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Redesigning Life


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Table of Contents

Introduction: The Gene Revolution 1: Natural Born Mutants 2: Supersize My Mouse 3: Light as a Life Tool 4: The Gene Scissors 5: Next Year's Models 6: The Molecular Farm 7: New Gene Therapy 8: Regenerating Life 9: Life as a Machine Conclusion: A Redesigned Planet? References Index

About the Author

John Parrington is an Associate Professor in Molecular and Cellular Pharmacology at the University of Oxford, and a Tutorial Fellow in Medicine at Worcester College, Oxford. He has published over 80 peer-reviewed articles in science journals including Nature, Current Biology, Journal of Cell Biology, Journal of Clinical Investigation, The EMBO Journal, Development, Developmental Biology, and Human Reproduction. He has extensive experience writing popular science, having published articles in The Guardian, New Scientist, Chemistry World, and The Biologist. He has also written science reports for the Wellcome Trust, British Council, and Royal Society. He is the author of The Deeper Genome, (OUP, 2015).


A comprehensive digest of the extraordinary scientific material relevant to the topic of gene editing. Parrington presents himself as the trusted tour guide of the latest developments in this rapidly advancing area of investigation. * Science Magazine *
There is a revolution going on in the life sciences, one that has already transformed scientific discovery and will soon change medicine. It could even see us altering the ecosystem in a precise, targeted way. This revolution has a name - CRISPR - and the key part of John Parrington's Redesigning Life is a good summary of the gene-editing technique that lies behind the acronym. * Matthew Cobb, New Scientist *
A thorough and comprehensive account of the methodologies for altering life that have been or are being developed, and the directions that they may take in future. * John Harris, Nature *
Parrington economically covers a huge swath of material, including a discussion of artificial genetic materials, and successfully communicates the excitement and relentless pace of the developments in this field. * Adrian Woolfson, Science *
painstakingly researched ... the examples themselves are clear, concise and often arresting ... an engaging and comprehensive introduction * Thomas Christie Williams, LSE Business Review *
Parrington's clear descriptions and diagrams combined with interesting snippets from the narrative and biography of scientific discovery make the science behind these developments readily accessible. Their relevance to our everyday lives is also highlighted with Parrington continually drawing connections between advances in the lab and their real world application. * Socialist Review *

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