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Physiological Basis of Respiratory Disease
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Physiological Basis of Respiratory Disease covers the important areas of respiratory physiology of particular relevance for pulmonary fellows and academic physicians. The text provides a solid basis for the understanding of the physiological basis for the major respiratory diseases. The contents are based on past and present research strengths of the Meakins Christie Laboratories with the majority of contributors comprised of former alumni. Physiological Basis of Respiratory Disease features a unique collection of topics, spanning classical physiological concepts to present day research. The clinical relevance of various research findings is examined and interpreted for the reader. Presented in an accessible format, need-to-know information is supported by a thorough selection of illustrations and references. The text is also applicable to other fields such as physiotherapy and inhalation therapy.
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Table of Contents

1. The History of Meakins Christie Laboratories ANATOMY 2. Histology and Gross Anatomy of the Respiratory Tract MECHANICS OF BREATHING 3. Statics 4. Dynamics 5. Statics - Dynamics in Infants 6. Maximum Expiratory Flow 7. Work of Breathing 8. Statics in Respiratory Disease 9. Structure - Function in Pulmonary Fibrosis 10. Structure - Function in COPD 11. Structure - Function in Asthma 12. Structure - Function in Airway Disease: Analysis by CT Imaging 13. Breathing Strategies in COPD and Asthma VENTILATION, PULMONARY CIRCULATION AND GAS EXCHANGE 14. Ventilation Distribution 15. Gas Convection and Diffusion 16. Microcirculation of the Lung 17. Pulmonary Edema 18. Hypoxia and Circulation (Pulmonary and Systemic) 19. Ventilation Perfusion Distribution 20. Ventilation Perfusion Distribution in Disease RESPIRATORY MUSCLES AND CONTROL OF BREATHING 21. Neural Control of Breathing 22. Actions of Respiratory Muscles 23. Biology of Respiratory Muscles 24. Respiratory Muscle Fatigue 25. Skeletal Muscles in COPD 26. Ventilatory Muscle Injury 27. Respiratory Consequence of Neuromuscular Disease 28. Sepsis and Ventilatory Muscle Function 29. Regulation of Blood Flow to the Muscles in Exercise THE AIRWAYS AND LUNG DEFENSE 30. Genetics and Respiratory Disease 31. Neurohumoral Control of the Airways 32. Mechanics of Airway Narrowing 33. Airway Smooth Muscle: The Contractile Phenotype 34. Airway Smooth Muscle: The Secretory Phenotype 35. Immunoglobulins and the Respiratory Tract 36. Mucociliary Clearance and Lung Disease 37. Mucociliary Clearance and Cystic Fibrosis 38. Epithelial Function in Lung Injury 39. Fluid and Electrolyte Transport in Airways 40. Cytokines in Lung Disease 41. Nitric Oxide and the Lung 42. Viral Infections and Airway Responsiveness 43. Role of Lipid Mediators in Respiratory Disease 44. Eicosanoids and the Lung 45. Lung Transplantation EXERCISE PHYSIOLOGY 46. Physiological Responses to Exercise 47. Exercise Limitation in Disease 48. Peripheral Muscle Dysfunction in Respiratory Disease SLEEP DISORDERED BREATHING 49. Physiology of the Upper Airways, Upper Airway Obstruction in Disease 50. Cardiovascular Consequences of Sleep and Breathing Disorders CLINICAL RESPIRATORY PHYSIOLOGY 51. Complexity of Disease 52. Sex and Gender Differences in Airway Behavior Across the Human Life Span 53. Measurement Techniques in Respiratory Mechanics 54. Esophageal Pressure Measurement 55. Evaluation of Pulmonary Function 56. Single Breath Carbon Monoxide Diffusing Capacity or Transfer Factor 57. Spirometric Predictions of Dyspnea and Exercise Limitation 58. Determinants of Decline in Lung Function 59. Assessment of Respiratory Muscles 60. Assessment of Acid Base Balance 61. Assessment of Bronchial Responsiveness 62. Pulmonary Function Assessment in the Infant 63. Evaluation of the Patient with Occupational Lung Disease 64. Physiologic Basis for Rehabilitation in COPD 65. Lung Volume Reduction Surgery 66. Diaphragmatic Responses to Stimulation 67. Clinical Cases

About the Author

Qutayba Hamid MD, PhD Associate Director, Meakins-Christie Laboratories McGill University Health Centre Montreal, Quebec. James Martin MD, BSc Professor of Medicine and Director of the Meakins-Christie Laboratories Professor of Medicine, McGill University Montreal, Quebec. Joanne Shannon MD, BA Professor of Medicine and Director of the Meakins-Christie Laboratories Professor of Medicine, McGill University Montreal, Quebec.

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