Foreword; Introduction; Part I. Basic Principles: 1. Principles of quantitative clinical pharmacology Pedro L Gambus and Sebastian Jaramillo; 2. Pharmacokinetic and pharmacodynamic modeling in anaesthesia Maria J. Garrido and Inaki F. Troconiz; 3. Drug interactions: additivity and synergy among anaesthetic drugs Jacqueline A. Hannam and Timothy G. Short; 4. Covariate analysis in clinical anaesthesia Luis I. Cortinez and Brian J. Anderson; 5. Signal analysis and response measurement Umberto Melia, Erik W. Jensen and Jose F. Valencia; 6. Application of PKPD and signal analysis to drug administration in anaesthesia Ross R. Kennedy; Part II. Targeting Effects: 7. Hypnotic effect: inducing unconsciousness and emergence from anaesthesia Sergio Vide, Catarina Nunes and Pedro Amorim; 8. Analgesia: effects on response to nociceptive stimulation Emmanuel Boselli and Mathieu Jeanne; 9. Personalized sedation and analgesia Michael M. Beck, Jeffrey B. Horn and Ken B. Johnson; 10. Respiratory depression Malin Jonsson Fagerlund; 11. Immobility Klaus T. Olkkola and Douglas J. Eleveld; 12. Effects on brain function Neus Fabregas and Adrian W. Gelb; 13. Targeted and individualized perioperative medicine for cognitive dysfunction Pauline Glasman, Alice Jacquens and Vincent Degos; 14. Cardiac and hemodynamic function Kai Kuck, Natalie Silverton and Michael K. Cahalan; 15. Effects of anaesthesia on thermoregulation Oliver Kimberger; 16. Effects of perioperative management on kidney function Xavier Borrat and Jordi Mercadal; 17. Effects on liver function Andre M. De Wolf and Jan F. A. Hendrickx; 18. Effects on fluid balance Robert G. Hahn; 19. Ventilation during general anaesthesia Lluis Gallart; 20. Epilogue: artificial intelligence methods Sebastian Jaramillo, Jose F. Valencia and Pedro L. Gambus; Index.
Presents a modern vision of anaesthesia, integrating technology and knowledge, to change how anaesthesia is taught and practised.
Pedro Gambus is a consultant anaesthetist at the Hospital CLINIC de Barcelona and Associate Professor of Biomedical Engineering at the Universitat de Barcelona, former postdoctoral fellow at the Department of Anesthesia at Stanford University, California, and Visiting Professor at the Department of Anesthesia and Perioperative Care University of California in San Francisco (UCSF). Jan Hendrickx is a consultant anaesthetist at Aalst General Hospital and Adjunct Professor at the Department of Anesthesia at Stanford University, California.