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Introduction to Pathophysiology PART ONE: CENTRAL CONCEPTS OF PATHOPHYSIOLOGY: CELLS AND TISSUES Unit I: The Cell * Cellular Biology * Altered Cellular and Tissue Biology * The Cellular Environment: Fluids and Electrolytes, Acids and Bases Unit II: Genes and Gene-Environment Interaction * Genes and Genetic Diseases * Genes, Environment, Life-style, and Common Diseases Unit III: Mechanisms of Self-Defense * Innate Immunity: Inflammation * Adaptive Immunity * Alterations in Immunity and Inflammation * Infection * Stress and Disease Unit IV: Cellular Proliferation: Cancer * Biology, Clinical Manifestations, and Treatment of Cancer * Cancer Epidemiology * Cancer in Children PART TWO: PATHOPHYSIOLOGIC ALTERATIONS: ORGANS AND SYSTEMS Unit V: The Neurologic System * Structure and Function of the Neurologic System * Pain, Temperature Regulation, Sleep, and Sensory Function * Alterations in Cognitive Systems, Cerebral Hemodynamics and Motor Function * Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction * Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders * Alterations of Neurologic Function in Children Unit VI: The Endocrine System * Mechanisms of Hormonal Regulation * Alterations of Hormonal Regulation Unit VII: The Reproductive Systems * Structure and Function of the Reproductive Systems * Alterations of the Reproductive Systems * Sexually Transmitted Infections Unit VIII: The Hematologic System * Structure and Function of the Hematologic System * Alterations of Erythrocyte Function * Alterations of Leukocyte, Lymphoid, and Hemostatic Function * Alterations of Hematologic Function in Children Unit IX: The Cardiovascular and Lymphatic Systems * Structure and Function of the Cardiovascular and Lymphatic Systems * Alterations of Cardiovascular Function * Alterations of Cardiovascular Function in Children Unit X: The Pulmonary System * Structure and Function of the Pulmonary System * Alterations of Pulmonary Function * Alterations of Pulmonary Function in Children Unit XI: The Renal and Urologic System * Structure and Function of the Renal and Urologic Systems * Alterations of Renal and Urinary Tract Function * Alterations of Renal and Urinary Tract Function in Children Unit XII: The Digestive System * Structure and Function of the Digestive System * Alterations of Digestive Function * Alterations of Digestive Function in Children Unit XIII: The Musculoskeletal System * Structure and Function of the Musculoskeletal System * Alterations of Musculoskeletal Function * Alterations of Musculoskeletal Function in Children Unit XIV: The Integumentary System * Structure, Function, and Disorders of the Integument * Alterations of the Integument in Children Unit XV: Multiple Interacting Systems * Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults * Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

About the Author

Kathryn L. McCance, RN, PhD Sue E. Huether, RN, PhD

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