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Paediatric Nephrology
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Table of Contents

Patient assessment History and examination Abnormalities of the urine and urinalysis The approach to the child with haematuria The approach to the child with proteinuria Radiological investigations Recommendations for ultrasound screening for renal abnormalities Percutaneous renal biopsy Renal histology Genetic testing and antenatal diagnosis The neonate The foetus and birth Perinatal 'bright' kidneys Neonatal disorders of fluid balance Neonatal renal venous thrombosis Congenital abnormalities Antenatal diagnosis of structural renal abnormalities Renal agenesis Horseshoe kidney, renal ectopia and duplex kidneys The multicystic dysplastic kidney (MCDK) Pelvi-ureteric junction (PUJ) abnormalities Megaureter Posterior urethral valves Urogenital sinus and cloacal abnormalities Absent abdominal musculature syndrome Urinary tract infection Background and clinical features Collection of urine samples and diagnosis Bacterial and host factors that predispose to infection Management Investigations The penis and foreskin Vulvovaginitis Enuresis Nocturnal enuresis Primary diurnal and secondary enuresis Bladder pathology Homeostasis Disorders of sodium and water: Basic principles Disorders of sodium and water: Hypernatraemia Disorders of sodium and water: Hyponatraemia Disorders of potassium: Basic principles Disorders of potassium: Hyperkalaemia Disorders of potassium: Hypokalaemia Disorders of calcium: Basic principles Disorders of calcium: Hypercalcaemia Disorders of calcium: Hypocalcaemia Disorders of magnesium: Basic principles Disorders of magnesium:Hypermagnesaemia Disorders of magnesium: Hypomagnesaemia Disorders of phosphate: Basic principles Disorders of phosphate: Hyperphosphataemia Disorders of phosphate: Hypophosphataemia Disorders of acid-base balance: Basic principles Disorders of acid-base balance: Acidosis Disorders of acid-base balance: Alkalosis Tubular disease Disorders of renal salt handling: Basic principles Disorders of renal salt handling: Proximal tubule Disorders of renal salt handling: Thick ascending limb Disorders of renal salt handling: Distal convoluted tubule Disorders of renal salt handling: Collecting duct Disorders of renal water handling Disorders of renal magnesium handling Rickets Tubulointerstitial nephritis (TIN) Renal calculi and nephrocalcinosis Renal calculi Specific causes of calculi, their investigation and management Nephrocalcinosis Glomerular disease Overview of inherited glomerular diseases Alport syndrome and thin basement membrane nephropathy Acute nephritis IgA Nephropathy (IgAN) Nephrotic syndromes: Definitions Congenital and Infantile Nephrotic Syndrome Steroid sensitive nephrotic syndrome: Presenting episode Steroid sensitive nephrotic syndrome: Relapsing disease Steroid resistant nephrotic syndrome (SRNS) Systemic disease affecting the kidney Systemic lupus erythematosus: Background, clinical evaluation and investigation Systemic lupus erythematosus: Treatment of non-renal SLE Systemic lupus erythematosus: Classification and treatment of lupus nephritis Systemic lupus erythematosus: B cell-targeted therapies Diabetes and metabolic syndrome Sickle cell disease Renal involvement in cystic fibrosis Sarcoidosis Mitochondrial cytopathies Fabry disease Amyloidosis The emergency renal management of inborn errors of metabolism (IEMs) Cystinosis Vasculitis The classification of paediatric vasculitis Investigation of primary systemic vasculitis The standard treatment of childhood vasculitis Henoch Schoenlein purpura Kawasaki disease Polyarteritis nodosa (PAN) The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides Takayasu arteritis Infections and the kidney Infections and the kidney Renal cystic diseases and ciliopathies Renal cystic diseases: Basic principles Autosomal Dominant Polycystic Kidney Disease (ADPKD) Renal structural abnormalities in Tuberous sclerosis Autosomal Recessive Polycystic Kidney Disease (ARPKD) Nephronophthisis (NPHP) Renal cysts and diabetes syndrome Renal dysplasia Syndromes associated with renal diseases Overviews of genetrics and renal abnormalities in inherited syndromes Down syndrome Williams syndrome Branchio-oto-renal syndrome Renal tumours Wilms' tumour Other renal tumours Hypertension Basic concepts of blood pressure, and defining hypertension in children Measurement of blood pressure in infants and children The investigation of hypertension in the young Renovascular hypertension Treatment Ambulatory blood pressure measurement in children Acute kidney injury Background, pathophysiology and causes Assessment and investigations Management Hypertension Nutrition in AKI Drug therapy Dialysis Follow up of AKI Haemolytic uraemic syndrome (HUS): Definitions Typical (D+) HUS: Epidemiology and notes HUS: Atypical Rhabdomyolysis Tumour lysis syndrome Chronic kidney disease Background and epidemiology Assessment of renal function Investigation of the cause of CKD Management: Overall aims Management: Fluid and electrolytes Management: Growth Management: Nutrition Management: Use of recombinant human growth hormone (rhGH) Management: Enteral feeding Management: Mineral and Bone Disorder (CKD-MBD) Management: Anaemia Management: Immunisation schedule for infants and children Preparation for renal replacement therapy Chronic peritoneal dialysis Principles of peritoneal dialysis Peritoneal dialysis solutions Peritoneal equilibrium test (PET) Peritonitis in patients on chronic peritoneal dialysis Sclerosing peritonitis Extracorporeal treatments Haemodialysis: Principles of haemodialysis Haemodialysis: The machine, dialysate and water Haemodialysis: Factors affecting the prescription Haemodialysis: Complications Haemodialysis: Adequacy Haemodialysis: Vascular access Haemodialysis: Blood-borne viruses Continuous renal replacement therapy (CRRT) Plasmapheresis and immunoadsorption Transplantation Renal transplantation immunology Vaccination after transplantation Kidney transplantation-the surgery Immunosuppressive therapy in renal transplant patients Diagnosis and treatment of transplant rejection Recurrent and de novo renal disease following renal transplantation Urinary tract infection post transplantation New onset diabetes after transplantation Infection post transplant Malignancy following renal transplantation Graft survival in transplant recipients Drug prescribing Basic principles Specific drug issues of importance Intraperitoneal drug doses Psychosocial issues Ethical issues Non-adherence in paediatric renal disease Long-term growth Long term survival of children on renal replacement therapy Palliative care Appendix Assessment of glomerular filtration rate (GFR) Furosemide test of urinary acidification DDAVP test Disodium pamidronate infusion Intravenous cyclophosphamide Guidelines for the use of Basiliximab (Simulect) Protocol for administration of blood to patients with or approaching CKD 5 Protocol for percutaneous transluminal angioplasty Travel information - Guidance for renal patients Guidelines for the treatment of swine flu (H1N1) infection in children with renal disease Miscellaneous

Reviews

`This is a book that makes the professional life of a paediatrician and paediatric nephrologist a lot easier...an excellent handbook in paediatric nephrology.' ACTA Paediatrics, June 2013 `The highly knowledgeable medical teams from Great Ormond Street Hospital for Children and the Royal Manchester Children's Hospital have revised and published another edition of Pediatric Nephrology. This is a true handbook in which the authors give the reader an overview of pediatric nephrology in a very systematic, educational and inspiring way Although in a compact format, most of the subject is thoroughly covered, and with the help of this book the reader will be able to handle most challenges. This edition should be available at any children's section, available to anyone who is on duty. For younger physicians who want to learn pediatric nephrology, it is obligatory!' Tidsskrift for Den norske legeforening, Feb 2013 `With this second edition, the handbook continues to function as a comprehensive quick reference, essentially covering all clinical aspects of normal and abnormal kidney function as well as diagnostic evaluation and treatment of clinical conditions in pediatric nephrology. This handbook successfully accomplishes its goals. It is a unique publication that truly does not have a comparable equivalent. This book certainly does not try to replace major textbooks but it is an extremely useful resource in its new edition. It will be widely used by clinicians at all levels. 5 stars!' Doody's Reviews the book is a must buy for all pediatric residents,its pediatric consultants, intensive care specialists, pediatric

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