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Novel Antimicrobial Agents and Strategies


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Preface THE PROBLEM OF MICROBIAL DRUG RESISTANCE Introduction History of the Origins, Development, and Use of Conventional Antibiotics Problems of Antibiotic Resistance Multiple Drug-Resistant (MDR), Extensively Drug-Resistant (XFR), and Pan-Drug-Resistant (PDR) Organisms MDR Mechanisms of Major Pathogens Antimicrobial Stewardship Programs Discussion CONVENTIONAL ANTIBIOTICS - REVITALIZED BY NEW AGENTS Introduction Conventional Antibiotics The Principle of Combination Antibiotic Therapy Antibiotic Resistance Breakers: Revitalize Conventional Antibiotics Discussion DEVELOPING NOVEL BACTERIAL TARGETS: CARBONIC ANHYDRASES AS ANTIBACTERIAL DRUG TARGETS Introduction Carbonic Anhydrases CA Inhibitors Classes of CAs Present in Bacteria Pathogenic Bacterial CAs Alpha-CAs in Pathogenic Bacteria Beta-CAs in Pathogenic Bacteria Gamma-CAs from Pathogenic Bacteria Conclusions MAGAININS - A MODEL FOR DEVELOPMENT OF EUKARYOTIC ANTIMICROBIAL PEPTIDES (AMPs) Introduction Magainins and Their Antimicrobial Action Magainins as Antibiotics Other Antimicrobial Uses of Magainins Future Prospects for Magainins ANTIMICROBIAL PEPTIDES FROM PROKARYOTES Introduction Bacteriocins Applications of Prokaryotic AMPs Development and Discovery of Novel AMP PEPTIDOMIMETICS AS ANTIMICROBIAL AGENTS Introduction Antimicrobial Peptidomimetics Discussion SYNTHETIC BIOLOGY AND THERAPIES FOR INFECTIOUS DISEASES Current Challenges in the Treatment of Infectious Diseases Introduction to Synthetic Biology Vaccinology Bacteriophages: A Re-emerging Solution? Isolated Phage Parts as Antimicrobials Predatory Bacteria and Probiotic Bacterial Therapy Natural Products Discovery and Engineering Summary NANO-ANTIMICROBIALS BASED ON METALS Introduction Silver Nano-Antimicrobials Copper Nano-Antimicrobials Zinc Oxide Nano-Antimicrobials Conclusions NATURAL PRODUCTS AS ANTIMICROBIAL AGENTS - AN UPDATE Introduction Antimicrobial Natural Products from Plants Antimicrobial Natural Products Bearing an Acetylene Function Antimicrobial Carbohydrates Antimicrobial Natural Chromenes Antimicrobial Natural Coumarins Antimicrobial Flavonoids Antimicrobial Iridoids Antimicrobial Lignans Antimicrobial Phenolics Other Than Flavonoids and Lignans Antimicrobial Polypeptides Antimicrobial Polyketides Antimicrobial Steroids Antimicrobial Terpenoids Miscellaneous Antimicrobial Compounds Platensimycin Family as Antibacterial Natural Products PHOTODYNAMIC ANTIMICROBIAL CHEMOTHERAPY Introduction The Administration and Photoactivation of PS Applications of PACT Based on MB The Applications of PACT Based on ALA Future Prospects THE ANTIMICROBIAL EFFECTS OF ULTRASOUND Introduction The Antimicrobial Activity of Ultrasound Alone The Antimicrobial Activity of Assisted Ultrasound SynergisticEffects Sonosensitizers Future Prospects ANTIMICROBIAL THERAPY BASED ON ANTISENSE AGENTS Introduction Antisense Oligonucleotides First-Generation ASOs Second-Generation ASOs Third-Generation ASOs Antisense Antibacterials Broad-Spectrum Antisense Antibacterials Methicillin-Resistant Staphylococcus aureus (MRSA) RNA Interference (RNAi) Progress Using siRNA Discussion NEW DELIVERY SYSTEMS - LIPOSOMES FOR PULMONARY DELIVERY OF ANTIBACTERIAL DRUGS Introduction Pulmonary Drug Delivery Liposomes as Drug Carriers in Pulmonary Delivery Present and Future Trends of Liposome Research in Pulmonary Drug Delivery Conclusions Index

About the Author

Professor David Andrew Phoenix studied Biochemistry at degree and doctoral level at Liverpool University which in 2009 awarded him a Doctor of Science for his impact on the field. In 2000 he was appointed Professor of Biochemistry, at the University of Central Lancashire (UCLan) and has held visiting chairs in Canada and Russia. He has published over 150 papers as well as a number of edited collections and monographs. He is a Fellow of the Royal Society of Chemistry, The Society of Biology, The Institute of Mathematics and Its Applications and the Royal Society of Medicine. Since 2008 he has been the Deputy Vice Chancellor of UCLan and also chairs a research institute in Shenzhen focused on nanotechnology and biomedical engineering. He was made an Officer of the Most Excellent Order of the British Empire in 2010 for services to Science and Higher Education and recognized as an Academician by the Academy of Social Sciences in 2012. Dr. Frederick Harris studied at UCLan, graduating with a Bachelor of Science in Biochemistry and Microbiology in 1993 before gaining his Doctorate for work on the penicillin-binding proteins of Escherichia coli in 1998. Subsequently, he has undertaken research at Utrecht University and the Leibniz-Centre for Medicine and Biosciences, Germany. In 2000, Frederick started as a Research Fellow at UCLan and now has more than 75 publications to his name, which primarily focus on antimicrobial and anticancer peptides. Dr. Sarah Rachel Dennison graduated from the University of Wales, Bangor with a Bachelor of Science in Environmental Biology in 1999. Subsequently, she undertook postgraduate research in Biochemistry / Biophysics, which led to a doctorate in 2004. Currently, Sarah is a Research Associate in the School of Pharmacy and Biomedical Sciences at UCLan where she is investigating the role of amphiphilicity in the function of antimicrobial peptides using a number of biophysical techniques.


"This would have been a valuable addition to help put some of these new methodologies into context." (ChemMedChem, 1 September 2015)

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