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Molecular Biology


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Table of Contents

1. Basic Genetics 2. Cells and Organisms 3. DNA, RNA and Protein 4. Genes, Genomes and DNA 5. Cell Division and DNA Replication 6. Transcription of Genes 7. Protein Structure and Function 8. Protein Synthesis 9. Regulation of Transcription in Prokaryotes 10. Regulation of Transcription in Eukaryotes 11. Regulation at the RNA Level 12. Processing of RNA 13. Mutations 14. Recombination and Repair 15. Mobile DNA 16. Plasmids 17. Viruses 18. Bacterial Genetics 19. Diversity of Lower Eukaryotes 20. Molecular Evolution 21. Nucleic Acids: Isolation, Purification, Detection, and Hybridization 22. Recombinant DNA Technology 23. The Polymerase Chain Reaction 24. Genomics and DNA Sequencing 25. Analysis of Gene Expression 26. Proteomics: The Global Analysis of Proteins Glossary Index

About the Author

David P. Clark did his graduate work on bacterial antibiotic resistance to earn his Ph.D. from Bristol University, in the West of England. During this time, he visited the British Government's biological warfare facility at Porton Down and was privileged to walk inside the (disused) Black Death fermenter. He later crossed the Atlantic to work as a postdoctoral researcher at Yale University and then the University of Illinois. David Clark recently retired from teaching Molecular Biology and Bacterial Physiology at Southern Illinois University which he joined in 1981. His research into the Regulation of Alcohol Fermentation in E. coli was funded by the U.S. Department of Energy, from 1982 till 2007. From 1984-1991 he was also involved in a project to use genetically altered bacteria to remove contaminating sulfur from coal, jointly funded by the US Department of Energy and the Illinois Coal Development Board. In 1991 he received a Royal Society Guest Research Fellowship to work at Sheffield University, England while on sabbatical leave. He has supervised 11 master's and 7 PhD students and published approximately 70 articles in scientific journals. He has written or co-authored several textbooks, starting with Molecular Biology Made Simple and Fun (with Lonnie Russell; (Cache River Press, First edition, 1997) which is now in its fourth edition. Other books are Molecular Biology and Biotechnology (both published by Elsevier) He recently wrote a popular science book, Germs, Genes, & Civilization: How Epidemics Shaped Who We Are Today (2010, Financial Times Press/Pearson). David is unmarried, but his life is supervised by two cats, Little George and Mr Ralph.


"This is an excellent book. It is very lucidly written. Clark covers a suitable set of topics, and treats each topic very thoroughly...He is very up-to-date in his coverage of the material." - John G. Burr, University of Texas at Dallas "This textbook is very comprehensive, covering nearly all aspects of molecular biology and genetics. The textbook excels in defining key terms in a clear and understable way...The sprinkling of little side stories...keeps the reader interested, and kept me glued throughout the text." - B. Franklin Pugh, Penn State University "The author did a very good job covering this vast subject and offered many insightful perspectives." - John F. Cannon, University of Missouri

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