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Mineralized Tissues in Oral and Craniofacial Science
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Mineralized Tissues in Oral and Craniofacial Science is a major comprehensive update on knowledge in the field of mineralized tissues in the oral and craniofacial region. Drs. McCauley and Somerman assembled an international team of researchers and clinicians, offering a global perspective on the current knowledge in this field. Basic and clinical correlates reinforce the significance of research to clinical diagnoses and therapies, written in a manner that lends easily to their use for case study teaching venues. Section 1 features the many aspects of bone in the craniofacial region, including embryology, cell biology, and stem cell biology. Section 2 focuses on teeth-tooth development, dentin, enamel, cementum, and tooth regeneration. Section 3 discusses the interaction between bones and teeth, including those associated with inflammatory processes, periodontal ligaments, biomechanics, and other impact factors-such as nutrition, metabolic bone diseases and therapeutic modalities. The novel approach of linking the basic principles of the cell and molecular biology of hard tissues to clinical correlates will appeal to readers at all levels of their research careers, both students and faculty; faculty interested in a comprehensive text for reference; and clinicians interested in the biologic aspects of bones and teeth.
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Table of Contents

Contributors vii Preface xv Acknowledgments xvii Foreword xix Section 1 Bones of the oral-dental and craniofacial complex 1 1 Embryology of craniofacial bones 3 Antonio Nanci and Pierre Moffatt 2 Clinical correlate: cleft lip and palate 13 Emily R. Gallagher and Joel Berg 3 Cell and molecular biology of the osteoclast and bone resorption 17 Martin Biosse-Duplan, William C. Horne, and Roland Baron 4 Clinical correlate: osteopetrosis 29 Paul C. Edwards and Nasser Said-Al-Naief 5 Clinical correlate: CLCN7-associated autosomal recessive osteopetrosis 35 Piranit Nik Kantaputra 6 Osteoblasts of craniofacial bone 43 Renny T. Franceschi, Chunxi Ge, and Christopher G. Wilson 7 Clinical correlate: cleidocranial dysplasia 59 Shu Takeda, Nobuhiko Haga, and Keiji Moriyama 8 Cell biology of craniofacial bone: osteocytes 63 Lynda F. Bonewald 9 Clinical correlate: Van Buchem disease 71 H.-J. Prins, A.L.J.J. Bronckers, and J. Klein-Nulend 10 Stem cell biology in the craniofacial apparatus 79 Carolina Parada, Kentaro Akiyama, Yang Chai, and Songtao Shi 11 Clinical correlate: stem cell therapy for craniofacial bone regeneration 93 Giorgio Pagni, William V. Giannobile, and Darnell Kaigler 12 Extracellular matrix and mineralization of craniofacial bone 99 Marc D. McKee, Monzur Murshed, and Mari T. Kaartinen 13 Clinical correlate: osteogenesis imperfecta 111 Peter H. Byers Section 2 Teeth 117 14 Tooth development 119 Irma Thesleff and Emma Juuri 15 Clinical correlate: tooth agenesis 129 Rena N. D Souza and Gabriele I. Mues 16 Dentin 135 Chunlin Qin and Jian Q. Feng 17 Clinical correlate: dentinogenesis imperfecta, restorative procedures, and caries 143Yong-Hee Patricia Chun and Jan CC. Hu 18 Enamel fabrication: the story of amelogenesis 153 Carolyn W. Gibson and Malcolm L. Snead 19 Clinical correlate: amelogenesis imperfecta 163 Rochelle G. Lindemeyer 20 Cementum 169 Brian L. Foster and Martha J. Somerman 21 Clinical correlate: case study of identical twins with cementum and periodontal defects resulting from odontohypophosphatasia 183 Thaisangela L. Rodrigues, Ana Paula Georgetti, Luciane Martins, Joao S. Pereira Neto, Brian L. Foster, and Francisco H. Nociti Jr. 22 Dental engineering: tooth regeneration 191 Weibo Zhang and Pamela C. Yelick 23 Clinical correlate: periodontal regeneration 201 Jia-Hui Fu and Hom-Lay Wang 24 Clinical correlate: natural tooth regeneration 207 Gary E. Heyamoto 25 Clinical correlate: regenerative endodontics in an immature tooth with pulpal necrosis and periapical pathosis 211 Tatiana M. Botero, Christine M. Sedgley, Martha I. Paniagua, and Diego M. Tobon Section 3 Bones and teeth 217 26 Bone and tooth interface: periodontal ligament 219 P. Mark Bartold 27 Clinical correlate: two cases of destructive periodontal disease 231 Rahime Meral Nohutcu 28 Periodontal disease and infl ammationinduced bone remodeling 237 Dana T. Graves, Elliot D. Rosenstein, Carlos Rossa Jr., and Joseph P. Fiorellini 29 Clinical correlate: endodontic lesions 249 Matthew DiAndreth and Hongjiao Ouyang 30 Biomechanics of teeth in bone: function, movement, and prosthetic rehabilitation 255 Susan W. Herring 31 Clinical correlate: biomechanics of teeth in bone 269 Gregory King, Geoffrey Greenlee, Paola Leone, and Gregory Vaughn 32 Impact of metabolic bone disease on craniofacial bones and teeth 277 Jill Bashutski, L. Susan Taichman, and Laurie K. McCauley 33 Clinical correlate: renal osteodystrophy 291 Flavia Pirih, Gabriella Tehrany, and Tara Aghaloo 34 Mineral metabolism and its impact on craniofacial bones and teeth 297 Jian Q. Feng and Chunlin Qin 35 Clinical correlate: mineral metabolism and disruption of dentoalveolar development in a case of craniometaphyseal dysplasia (CMD) 305 Hai Zhang and Brian Foster 36 Sun, nutrition, and the mineralization of bones and teeth 311 Philippe P. Hujoel 37 Clinical correlate: vitamin D deficiency 327 Ana Lucia Seminario and Elizabeth Velan 38 Impact of therapeutic modalities on craniofacial bones and teeth 331 Purnima S. Kumar and Angelo Mariotti 39 Clinical correlate: osteoradionecrosis of the jaws (ORN) 343 Nicholas M. Makhoul and Brent B. Ward Index 349 Figures from the book are available for download at www.wiley.com/go/mccauley

About the Author

Laurie K. McCauley, DDS, PhD is the William K. and Mary Anne Najjar Professor and Chair of the Department of Periodontics and Oral Medicine, and Professor in the Department of Pathology at the University of Michigan in Ann Arbor, Michigan. Martha J. Somerman, DDS, PhD, formerly Dean and Professor, University of Washington School of Dentistry, is currently the Director of the National Institute of Dental and Craniofacial Research, and Chief, Laboratory for Oral Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health in Bethesda, Maryland.

Reviews

Notwithstanding these minor points, the book is very wellstructured and provides a comprehensive overview of all themineralized tissues in in the craniofacial complex, withinteresting aspects of the requirements for successful clinicalapplications. (Implant Dentistry, 1 June2013) In summary , this book is commendable for theextent of its content and its ability to remain up to date. It serves the needs not only of first-year students , butalso of various specialists in training and all practitionerslooking for a rationale in their diagnosis andtreatment. (British Dental Journal, 8 December2012)

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