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The Massachusetts General Hospital Guide to Depression


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Table of Contents

Foreword-MGH Guide to Depression

Jerrold Rosenbaum

Foreword-Introduction and Historical Perspective

Maurizio Fava

Preface - Benjamin G. Shapero, David Mischoulon, Cristina Cusin

Part 1 Severe and Comorbid Conditions

Chapter 1

Treatment-Resistant Depression

Cristina Cusin and Stefan Peyda

Chapter 2

Co-Occurring MDD and Problematic Alcohol Use

Paola Pedrelli and Kate H. Bentley

Part 2 Special Population Considerations

Chapter 3

Depression and Chronic Medical Illness: New Treatment Approaches

Trina E. Chang and Sean D. Boyden

Chapter 4

Culture and Depression: Clinical Considerations for Racial and Ethnic Minorities

Nhi-Ha Trinh and Taquesha Dean

Chapter 5

Early Onset of Depression During Childhood and Adolescence

Benjamin G. Shapero and Erica Mazzone

Chapter 6

Cross-Cultural Approaches to Mental Health Challenges Among Students

Xiaoqiao Zhang, Tat Shing Yeung, Yi Yang, Rohit M. Chandra, Cindy H. Liu, Dana Wang, Sukhmani K. Bal, Yun Zhu, Rebecca Nika W. Tsai, Zhenyu Zhang, Lusha Liu and Justin A. Chen

Chapter 7

Depression After Traumatic Brain Injury

Lauren B. Fisher, Garrett Thomas, Ryan A. Mace, and Ross Zafonte

Part 3 Medication Approaches

Chapter 8

Personalized Medicine

Simmie L. Foster, Samuel R. Petrie, David Mischoulon, and Maurizio Fava

Chapter 9

Depression, Antidepressants, and Sexual Functioning

Christina M. Dording and Sean D. Boyden

Chapter 10

Ketamine as a Rapid Antidepressant

Cristina Cusin

Chapter 11

Neuroactive Steroids and Depression

Karen K. Miller

Part 4 Psychotherapy Approaches

Chapter 12

Unified Protocol for Treatment of Depression

Kate H. Bentley, Laren R. Conklin, James F. Boswell, Benjamin G. Shapero, and Olenka S. Olesnycky

Chapter 13

Mindfulness Based Cognitive Therapy

Benjamin G. Shapero, Jonathan Greenberg, Paola Pedrelli, Gaelle Desbordes, and Sara W. Lazar

Chapter 14

The Role of Technology in the Treatment of Depression

Paola Pedrelli, Kate H. Bentley, Esther Howe, and Benjamin G. Shapero

Part 5 Alternative Treatment Approaches

Chapter 15

Supplements and Natural Remedies for Depression

David Mischoulon and Nadia Iovieno

Chapter 16

The Effects of Tai Chi and Qigong on Anxiety and Depression

Albert Yeung, Benjamin Campbell, and Jessie S. M. Chan

Chapter 17

Yoga as a Treatment for Depression

Maren Nyer, Regina Roberg, Maya Nauphal, and Chris Streeter

Chapter 18


Marco Antonio Caldieraro and Paolo Cassano

About the Author

Benjamin G. Shapero, Ph.D.
Assistant in Psychology, Department of Psychiatry, Massachusetts General Hospital
Member of Faculty of Psychiatry, Harvard Medical School
1 Bowdoin Square, 6th Floor
Boston, MA 02114

David Mischoulon, M.D. Ph.D.
Director, Depression Clinical and Research Program, Massachusetts General Hospital
Associate Professor of Psychiatry, Harvard Medical School
1 Bowdoin Square, 6th Floor
Boston, MA 02114

Cristina Cusin, M.D.
Director, Translational Studies in the Depression Clinical and Research Program, Massachusetts General Hospital
Assistant Professor of Psychiatry, Harvard Medical School
1 Bowdoin Square, 6th Floor
Boston, MA 02114

David Mischoulon is an Associate Psychiatrist at Massachusetts General Hospital, an Associate Professor of Psychiatry at Harvard Medical School, and the Director of Research and Alternative Remedy Studies at the Depression Clinical and Research Program at Massachusetts General Hospital. Dr. Mischoulon graduated from the combined MD-PhD program at Boston University School of Medicine in 1994, and then interned in preliminary medicine at Carney Hospital from 1994-1995. From 1995-1998 he completed his residency in adult psychiatry at Massachusetts General Hospital, where he served as Chief Resident in Psychopharmacology. Dr. Mischoulon has authored or co-authored more than 100original articles, review articles, and book chapters, and has also co-edited a textbook on natural medications for psychiatric disorders.


"This guide presents the most up-to-date, cutting-edge pharmacological, non-pharmacological, somatic treatments and psychotherapeutic interventions for patients struggling with difficult-to-treat depression. ... The strength of this book lies in the chapters describing more novel treatments, which even the most seasoned psychiatrists are not necessarily familiar with. This book will be of great use to clinicians at all levels of experience." (Michael Easton, Doody's Book Reviews, April, 2019)

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