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Lymphatic Continuum Revisited

Lymphatic research has experienced a near explosion of activity in recent years, as awareness of the importance of lymphatic mechanisms to the continuum of human biology and disease has grown. This "lymphatic continuum" now easily encompasses cardiovascular disease, respiratory inflammation, obesity, autoimmune disease, and chronic transplant rejection, among many other pathologic conditionas. An exponential growth in technological tools for research has made possible a similar growth in our comprehension of the molecular regulatory processes that govern the normal development and function of the lymphatic system. The purpose of this volume is to review and document the wonderful growth of insight into the tools for lymphatic investigation, biological principles of the lymphatic system, and biological principles in lymphedema diagnosis and management, as well as the lymphatic biology of cancer and metastasis. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order ( Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit for more information about becoming a member
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Table of Contents

Introduction: The Lymphatic Continuum Revisited: Stanley G. Rockson. Part I: Tools for Lymphatic Investigation:. 1. Markers for Microscopic Imaging of Lymphangiogenesis and Angiogenesis: Peter Baluk and Donald M. McDonald. 2. New Horizons for Imaging Lymphatic Function: Ruchi Sharma, Juliet A. Wendt, John C. Rasmussen, Kristen E. Adams, Milton V. Marshall, and Eva M. Sevick-Muraca. 3. Peptide Targeting of Tumor Lymph Vessels: Pirjo Laakkonen, Lianglin Zhang, and Erkki Ruoslahti. 4. Lymphatic Tissue Engineering: Progress and Prospects: Thomas Hitchcock and Laura Niklason. 5. Animal Models for the Molecular and Mechanistic Study of Lymphatic Biology and Disease: William S. Shin and Stanley G. Rockson. Part II: Biological Principles of the Lymphatic System:. 6. Current Concepts in Lymphatic Vasculature Development: Guillermo Oliver and R. Sathish Srinivasan. 7. The Link between Lymphatic Function and Adipose Biology: Natasha Harvey. 8. Molecular Regulation of Lymphatic Contractility: Mariappan Muthuchamy and David Zawieja. 9. Lymphatic Vessels: Pressure- and Flow-Dependent Regulatory Reactions: Anatoliy A. Gashev. 10. Contractility Patterns of Human Leg Lymphatics in Various Stages of Obstructive Lymphedema: Waldemar Olszewski. 11. Cell Traffic and the Lymphatic Endothelium: Louise Anne Johnson and David G. Jackson. 12. Research Perspectives in Inherited Lymphatic Disease: An Update: Robert E. Ferrell and David N. Finegold. Part III: Biological Principles in Lymphedema Diagnosis and Management:. 13. Phenotypic Characterization of Primary Lymphedema: Fiona Connell, Glen Brice, and Peter Mortimer. 14. Estimating the Population Burden of Lymphedema: Stanley G. Rockson and Kahealani K. Rivera. 15. The Clinical Spectrum of Lymphatic Disease: Kavita Radhakrishnan and Stanley G. Rockson. 16. Cogenital Lymphatic Malformations: Francine Blei. 17. Lymphatics in Lung Disease: Souheil El-Chemaly, Stewart J Levine, and Joel Moss. 18. Lymphatic Involvement in Lymphangioleiomyomatosis: Connie G. Glasgow, Angelo M. Taveira-DaSilva, Thomas N. Darling, and Joel Moss. 19. Targeted Treatment for Lymphedema and Lymphatic Metastasis: Tomi Tervala, Erkki Suominen, and Anne Saaristo. Part IV: Lymphatic Biology of Cancer and Metastasis:. 20. Molecular Control of Lymphatic Metastasis: Marc G. Achen and Steven A. Stacker. 21. Lymphatic Vessel Activation in Cancer: Suvendu Das and Mihaela Skobe. Index of Contributors

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