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Long Acting Injections and Implants
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Table of Contents

An Introduction to Long Acting Injections and Implants.- Historical Overview of Long Acting Injections and Implants.- Host Response to Long Acting Injections and Implants.- Anatomy and Physiology of the Injection Site - Implications for Extended Release Parenteral Systems.- Drugs for Long Acting Injections and Implants.- Diseases and Clinical Applications that Can Benefit from Long Lasting Implants and Injections.- Oily (lipophilic) Solutions and Suspensions.- Aqueous Suspensions.- In Situ Forming Systems (Depots).- Microsphere Technologies.- Liposomes as Carriers for Controlled Drug Delivery.- Micro- and Nanoemulsions (Controlled Release Parenteral Drug Delivery Systems).- Nanosuspensions.- PEGylated Pharmaceutical Nanocarriers.- Protein PEGylation.- Self-Assembling Lipid Formulations.- Implantable Drug Delivery Systems Based on the Principles of Osmosis.- Microtechnologies for Drug Delivery.- Drug Eluting Stents.- Delivery of Peptides and Proteins via Long Acting Injections and Implants.- Injectable PLGA Systems for Delivery of Vaccine Antigens.- Methods of Sterilization for Controlled Release Injectable and Implantable Preparations.- In Vitro Drug Release Testing and In Vivo/In Vitro Correlation for Long Acting Implants and Injections.- Regulatory Issues and Challenges Associated with the Development of Performance Specifications for Modified Release Parenteral Products.

About the Author

Dr. Jeremy Wright is a Principal Engineer at the DURECT Corporation in Cupertino, California. He has over 30 years of experience in the development of drug delivery systems. He has been a key contributor to the development of implantable osmotic systems for veterinary and human use (DUROS(R)) and is currently involved in research and development of injectable depot systems. Dr. Wright is the inventor on over 50 patents. Dr. Diane J. Burgess is Distinguished Professor of Pharmaceutics, at the University of Connecticut. Her research efforts focus on gene and drug delivery and she has over 140 refereed publications. Dr. Burgess was the 2010 President of the Controlled Release Society (CRS), the 2002 President of the American Association of Pharmaceutical Scientists (AAPS) and is a CRS, AAPS and an American Institute for Medical and Biological Engineering (AIMBE) fellow. She is editor of the International Journal of Pharmaceutics.

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