Table of Contents

Preface to the seventh edition vii

From the preface to the first edition viii

Key to symbols used in this edition ix

Overview of the immune system x

Part 1 Immunity and the Immune System

1 The nature of immunity 3

2 Immune recognition 14

3 Lymphocyte development and activation 34

4 Lymphocyte interactions, cytokines and the lymphoid system 45

5 Immunoglobulins 63

6 Complement 79

7 Phagocytes 87

8 Mast cells, basophils and eosinophils 94

9 Killer cells 101

Part 2 Immunopathology

10 Immunity and infection 111

11 Primary and secondary immunodeficiency disorders 126

12 The generation of tissue‐damaging responses 148

13 Mechanisms of immunological tissue damage 167

14 Lymphoproliferative disease 179

15 Transplantation 191

16 Immunological therapy 203

Part 3 Self-assessment: answers

Self-assessment: answers 215

Index 221

About the Author

Ian Todd, MA, PhD, FHEA, is Associate Professor and Reader in Cellular Immunopathology, University of Nottingham, School of Life Sciences, Queen's Medical Centre, Nottingham.

Gavin Spickett, MA, LLM DPhil, BM BCh, FRCPath, FRCP, FRCPE, is Consultant and Senior Lecturer in Clinical Immunology, Royal Victoria Infirmary, Newcastle upon Tyne.

Lucy Fairclough, BSc, MSc, PhD, is Assistant Professor in Immunology, University of Nottingham, School of Life Sciences, Queen's Medical Centre, Nottingham.