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Laboratory Diagnosis in Neurology
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Table of Contents

Basics
1 The Cerebrospinal Flud - Its Production and Circulation in the Subarachnoid Space
2 Blood-Brain Barrier and Blood-CSF Barrier Function
The Blood-Brain Barrier
The Blood-CSF Barrier Function
3 Dynamics of Serum and Brain Proteins in the CSF and Blood
Serum Proteins in the CSF
Brain Proteins in the CSF
Brain Proteins in the Blood
Analysis
4 Basic Methods of Analysis
Immunochemistry and Immune Complex Analysis
Qualitative Electrophoretic Methods of Detection with or without Immunodetection
Immunohistochemistry
5 Cerebrospinal Fluid Analysis
Cerebrospinal Puncture
Measurement of Cerebrospinal Fluid Pressure
Cytodiagnosis
Proteins
Lactate and Glucose
Diagnosis of Pathogens
Markers of Dementia and Neuronal Destruction
6 Serum Analysis
General Serum Analysis
Special Serum Analysis
7 Autoantibodies and Antineural Antibodies
Autoantibodies
Antineural Antibodies
8 Neurogenetics
Basics
Monogenic Neurological Diseases
Polygenic or Multifactorial Neurological Diseases
9 Biopsy
Brain Biopsy
Nerve Biopsy
Muscle Biopsy
Clinical Pictures
10 Inflammation and Autoimmune Diseases
Inflammation Caused by Pathogens
Inflammation not Caused by Pathogens (Autoimmune Diseases)
11 Dementia and Psychiatric Disorders
Alzheimer's Disease
Lewy Body Dementia
Frontotemporal Lobar Degeneration
Multiple System Atrophy
Subcortical Atherosclerotic Encephalopathy
Creutzfeldt-Jacob Disease
Psychiatric Disorders
12 Cerebral Ischemia and Hemorrhage
Ischemic Cerebral Infarction
Intracerebral Hemorrhage
Subarachnoid Hemorrhage
Cerebral Hypoxia
13 Polyneuropathy
14 Pseudotumor Cerebri, Ventricular Drainage, and Neurosurgery
Pseudotumor Cerebri
External Ventricular Drainage, Ventriculoarterial and Ventriculoperitoneal Shunts
Cerebrospinal Fluid Rhinorrhea and Otorrhea
15 Epileptic Seizures
16 Brain Tumors
Primary Brain Tumors
Secondary Brain Tumors
Malignant Non-Hodgkin Lymphoma, Leukemia, and Meningeosis blastomatosa
17 Metabolic Disorders
Mitochondrial Diseases
Lysosomal Diseases
Peroxisomal Diseases
Cerebrotendinous Xanthomatosis (CTX)
Leukodystrophy / Leukocephalopathy in Organic Aciduria
Diseases of Copper Metabolism
Specialized Laboratories
18 Parasitosis and Tropical Diseases
Appendix
19 CSF Reports
Goettingen CSF Report
Procedure of CSF Analysis
Evaluation
Interpretation
20 Quality Control of Protein Analysis
Special Features of CSF Analysis
Quality Control of Individual Parameters
Quality Control of CSF Cytodiagnosis
21 Reference Ranges of Analytes in CSF and Serum
Electrolytes and Substrates
Proteins
Amino Acids, Lipids, and Vitamins
Cells
Index

About the Author

Professor, CSF and Complexity Studies, University of Goettingen, Goettingen, Germany

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