Intraperitoneal Cancer Therapy


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Table of Contents

PERITONEUM: EMBRYOLOGY, ANATOMY, AND PHYSIOLOGY. Embryology and Anatomy of the Peritoneal Cavity. Structure and Function of the Mesothelial Cell. Applied Radiological Anatomy of the Peritoneal Cavity. Peritoneal Drug Transport. PERITONEAL CARCINOMATOSIS: BASIC MECHANISMS. Molecular Biology of Peritoneal Carcinomatosis. Dissemination and Adhesion of Peritoneal Cancer Cells to the Peritoneal Wall. Genomic Approaches to Peritoneal Carcinomatosis. Surgery, Wound Healing, and Peritoneal Minimal Residual Disease in Colorectal Cancer. Role of the Greater Omentum in the Pathogenesis of Peritoneal Carcinomatosis. Lymphatic Transport and the Diaphragmatic Stomata. INTRAPERITONEAL DRUG THERAPY: BASIC PRINCIPLES. Pharmacokinetics of Intraperitoneal Cytotoxic Drug Therapy. Tissue Transport and Pharmacodynamics of Intraperitoneal Chemotherapy. Mathematical Models of Intraperitoneal Drug Delivery. SURGICAL TECHNIQUES FOR INTRAPERITONEAL DRUG DELIVERY. Management of Peritoneal Metastases Using Cytoreductive Surgery and Perioperative Chemotherapy. Chemoperfusion Techniques and Technologies. Port Placement for Intraperitoneal Chemotherapy. CLINICAL RESULTS OF INTRAPERITONEAL DRUG DELIVERY. Intraperitoneal Chemotherapy for Ovarian Cancer. Cytoreductive Surgery and HIPEC in the Treatment of Advanced Epithelial Ovarian Cancer and Serous Papillary Peritoneal Carcinoma. Pseudomyxoma Peritonei. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Metastatic Colorectal Cancer with Peritoneal Surface Disease. Diffuse Malignant Peritoneal Mesothelioma: Current Concepts in Evaluation and Management. Gastric Cancer and Intraperitoneal Chemotherapy. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Small Bowel Adenocarcinoma. Peritoneal Surface Malignancy from Neuroendocrine Tumors. Treatment Considerations for High-Grade Appendiceal Adenocarcinoma. Systemic Therapy for Appendiceal Cancer. Toxicity and Morbidity of IP Drug Therapy. Safety Considerations and Occupational Hazards. Role of CRS/HIPEC in the Management of Malignant Ascites. NOVEL AND EXPERIMENTAL APPROACHES. Development of Drug-Loaded Particles for Intraperitoneal Therapy. Biomaterials and Drug Delivery Systems for Intraperitoneal Chemotherapy. Intraperitoneal Nonviral Nucleic Acid Delivery in the Treatment of Peritoneal Cancer. Immunotherapy of Peritoneal Carcinomatosis. The Promise of Oncolytic Viral Therapy for the Treatment of Peritoneal Surface Malignancies. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC).

About the Author

Edited byWim P. Ceelen, MD, PhD, professor of surgery, Ghent University Hospital, BelgiumEdward Levine, MD, professor of surgery and chief of surgical oncology, Wake Forest University, Winston-Salem, USA


"The unique feature of this book is its complete coverage of all essentials for treating peritoneal surface malignancies -- it is truly a "one stop shop"... The quality of this book is superb and the digital version provides an extra dimension. It is unique in the comprehensive coverage of this highly specific topic and cannot readily be compared to other books." - Carlos HF Chan, MD, PhD (University of Iowa Hospitals and Clinics), 5 stars, Doody Enterprises

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