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Innovative drug development for headache disorders


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Screening models 1: Bolette Christiansen, Trine Kvist, Anders A. Jensen and Hans Brauner-Osborne: The human GABA transporter GAT-2 - From cloning to high throughput screening 2: Peter Goadsby: Low throughput preclinical models for headache 3: Messoud Ashina: Human models - screening models Trials methodology 4: Peer Tfelt-Hansen: Stricter success criteria, qualitative and quantitative end points: Acute vs. prevention trials 5: Carl G.H. Dahloef: Health related quality of life and similar end points 6: Michel D. Ferrari: Clinically relevant designs and outcome measures for acute migraine trials 7: E. Marchioni, S. Colnaghi, M. Versino, A. Pichiecchio, E. Tavazzi and G. Nappi: Effectiveness of different steroid dosage in Tolosa-Hunt syndrome with different phenotypes: some critical points about the new HIS classification 8: Jes Olesen: Discussion summary: Trials methodology NO and spreading depression modulators 9: Boris A. Chizh: Inducible nitric oxide synthase and development of new migraine treatments 10: Kevin C. Brennan and Andrew C. Charles: Mechanisms of cortical spreading depression as targets for migraine therapy 11: Peter R. Blower and Paul C. Sharpe: Tonabersat 12: Nabih Ramadan: Discussion Summary: NO and spreading depression modulators CGRP and 5-HT modulators 13: Jes Olesen and Inger Jansen-Olesen: Calcitonin gene-related peptide (CGRP): relevance for migraine 14: Pramod Saxena: New 5-HT related drug targets 15: L. Juhl, L. Edvinsson, J. Olesen, I. Jansen-Olesen: Effect of two novel CGRP-binding compounds in a closed cranial window rat model 16: Jacob Moller Hansen, Alexandra Maria Rahmann, Troels Wienecke, Jes Olesen, Messoud Ashina: Vasoactive intestinal polypeptide is unlikely to be a target for headache and migraine treatment 17: Rigmor Jensen: Discussion Summary: CGRP and 5-HT modulators Ion Channel modulators and antiepileptics 18: Arn M.J.M. van den Maagdenberg: Migraine: from genes to pathophysiology - transgenic mouse models of migraine 19: Inger Jansen-Olesen and Kenneth Beri Ploug: Katp channels and migraine 20: Michael Rogawski: Antiepileptic drugs and migraine 21: Pramod Saxena: Discussion Summary: Ion channel modulators and antiepileptics Other future targets for headache therapy 22: Kirk W Johnson, Eric S. Nisenbaum, Michael P. Johnson, Donna K. Dieckman, Amy Clemens-Smith, Edward R Siuda, Colin P. Dell, Veronique Dehlinger, Kevin J. Hudziak, Sandra A. Filla, Paul L. Ornstein, Nabih M Ramadan and David Bleakman: Innovative drug development for headache disorders - Glutamate 23: Beatriz Fioravanti & Todd Vanderah: The modulation of TRPV1 channels by cannabinoid1 receptors 24: Christian Waeber: Future targets for headache therapy: Prostanoids 25: Cristina Tassorelli, Rosaria Greco, Armando Perrotta, Simona Buscone, Giorgio Sandrini, Giuseppe Nappi: Role of anandamide in the modulation of nitroglycerin-induced hyperalgesia - a study in the rat

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