Table of Contents

About the Authors, xvii Contributors, xviii Preface and Acknowledgments, xix 1 OVERVIEW OF THE IMMUNE SYSTEM, 1 2 ELEMENTS OF INNATE AND ACQUIRED IMMUNITY, 11 3 IMMUNOGENS AND ANTIGENS, 29 4 ANTIBODY STRUCTURE AND FUNCTION, 41 5 ANTIGEN-ANTIBODY INTERACTIONS, IMMUNE ASSAYS, AND EXPERIMENTAL SYSTEMS, 61 6 THE GENETIC BASIS OF ANTIBODY STRUCTURE, 81 7 BIOLOGY OF THE B LYMPHOCYTE, 93 8 ROLE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE IMMUNE RESPONSE, 107 9 BIOLOGY OF THE T LYMPHOCYTE, 125 10 ACTIVATION AND FUNCTION OF T AND B CELLS, 141 11 CYTOKINES, 165 12 TOLERANCE AND AUTOIMMUNITY, 183 13 COMPLEMENT, 205 14 HYPERSENSITIVITY: TYPE I, 221 15 HYPERSENSITIVITY: TYPES II AND III, 237 16 HYPERSENSITIVITY: TYPE IV, 247 17 IMMUNODEFICIENCY DISORDERS AND NEOPLASIAS OF THE LYMPHOID SYSTEM, 255 18 TRANSPLANTATION, 285 19 TUMOR IMMUNOLOGY, 299 20 RESISTANCE AND IMMUNIZATION TO INFECTIOUS DISEASES, 313 Glossary, 337 Appendix: Partial List of CD Antigens, 365 Index, 369

About the Author

Dr. Richard Coico is Professor and Chairman of the Department of Microbiology and Immunology and Dean at the City University of New York Medical School. He directs CUNY Microbiology and Immunology courses and also participates directly in the teaching of immunology to graduate students. Dr. Sunshine is a Senior Scientist at the Health Effects Institute in Cambridge, Massachusetts. He is also a lecturer in the Department of Pathology at Tufts University School of Medicine.

Reviews

"The material is presented in an easy to read fashion, and new advances in the field are discussed." ( Doody's , April 2009)