The Hidden Life of the Basal Ganglia


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Table of Contents

Preface xi
Acknowledgments xiii
I Introduction and Background
1 The Basal Ganglia: Why and Where? 3
2 Cellular Anatomy and Biochemistry of the Basal Ganglia 15
3 The Synaptic Connections of the Basal Ganglia Network 27
4 Computational Modeling of Brain and Behavior 39
5 Principles of Neurophysiological Data Acquisition 43
6 Principles of Neurophysiological Analysis 61
II Computational Physiology of the Healthy Basal Ganglia
7 Physiology of the Basal Ganglia 77
8 Basal Ganglia Physiology: The Roads Less Traveled 89
9 Box-and-Arrow Rate Models of the Basal Ganglia 105
10 Reinforcement-Learning Actor/Critic Models of the Basal Ganglia 117
11 Multiple-Critics, Multiobjective Optimization Models of the Basal Ganglia 133
12 The Basal Ganglia as one of many State-to-Action Loops 145
III Computational Physiology of Basal Ganglia Disorders and their Therapy
13 Parkinson's Disease and other Basal Ganglia-Related Human Disorders 163
14 Animal Models of Parkinson's Disease 171
15 Physiology of Parkinson's Disease: Animal Models 179
16 Physiology of Parkinson's Disease: Human 195
17 Pharmacotherapy of Parkinson's Disease 203
18 Deep Brain Stimulation Therapy for Parkinson's Disease 215
19 Closing the Loop on Parkinson's Disease and Basal Ganglia-Related Disorders 225
IV From the Basal Ganglia and Brain to the Mind
20 The Basal Ganglia, Free Will, and Human Responsibility 241
Notes 247
References 261
Index 295

About the Author

Hagai Bergman is Simone and Bernard Guttman Chair in Brain Research and Professor of Physiology in the Edmond and Lily Safra Center (ELSC) for Brain Research and Faculty of Medicine at the Hebrew University of Jerusalem.

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