Preface
Acknowledgments 1. Seduced by Drug Discovery
2. Proscar and Propecia: the Gary and Jerry Show
3. Basic research, snake venoms and ACE inhibitors: Ondetti,
Cushman and Patchett
4. HIV protease inhibitors: weapons in the way against HIV/AIDS
5. Statins: protection against heart attacks and strokes -
Hallelujah
6. The perils of Primaxin
7. The discovery of taxol: Wall, Horwitz, Holton
8. Avermectins: molecules of life battle parasites
9. Fludalanine: nice try but no cigar
10. Diabetes breakthroughs: Thornberry and Weber
11. Take it off! Take it all off! Drugs for weight reduction
12. The conquest of hepatitis C: telaprevir and beyond Appendix A:
The small molecules of life: some basics of chemistry
Appendix B: The basics of protein structure
Appendix C: Proteins perform multiple functions: enzymes,
receptors, ion channels
Appendix D: The basics of drug discovery and development
Appendix E: Structures of key molecules
Eugene H. Cordes previously served as Vice President of
Biochemistry and Molecular Biology in the Research Laboratories of
Merck and Company and as President of Research and Development at
Sterling Winthrop Pharmaceuticals Inc. During his career, he
received awards for his classroom instruction at both Indiana
University and the University of Michigan. He is the author of The
Tao of Chemistry and Life (OUP 2009) and several biochemistry
textbooks.
"This is a remarkable book... At a time when the business models
for modern a pharma are being challenged, this book reminds us of
the heroes in the research trenches behind the science of drug
discovery. The book is arranged as a compendium of vignettes, each
centered around a particular medicinal chemistry puzzle,
highlighting some of the most transformative discoveries for human
health in modern medicine, particularly the life-saving development
of effective
HIV-protease inhibitors for HIV-AIDS, the understanding and
chemical conquest of Taxol and its cousins for treating metastatic
cancers, and the recent development of efficacious drugs for
hepatitis C.
Hallelujah Moments distinguishes itself in its ability to
communicate the human side of the science, the daredevil nature of
drug discovery (there are so many trap doors along the way), and
the science itself, in ever-increasing doses." -- David Berkowitz,
University of Nebraska-Lincoln
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