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Goldman's Cecil Medicine

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Table of Contents

Cecil medicine, 24th edition Edited by Lee Goldman and Andrew I. Schafer Part 1: Social and Ethical Issues in Medicine 1: Approach to Medicine, the Patient, and the Medical Profession: Medicine as a Learned and Humane Profession Lee Goldman Editor: Goldman, Lee 2: Bioethics in the Practice of Medicine Ezekiel Emanuel Editor: Goldman, Lee 3: Care of Dying Patients and Their Families Robert Arnold Editor: Goldman, Lee 4: Cultural Context of Medicine Victoria M. Taylor Editor: Goldman, Lee 5: Socioeconomic Issues in Medicine Steven Schroeder Editor: Goldman, Lee Part 2: Principles of Evaluation and Management 6: Approach to the Patient: History and Physical Examination David Simel Editor: Goldman, Lee 7: Approach to the Patient with Abnormal Vital Signs David L. Schriger Editor: Goldman, Lee 8: Statistical Interpretation of Data Thomas Newman;Charles McCulloch Editor: Goldman, Lee 9: Using Data for Clinical Decisions Thomas Lee Editor: Goldman, Lee 10: Measuring Health and Health Care Stephan D. Fihn Editor: Goldman, Lee 11: Quality of Care and Safety of Patients Robert Wachter Editor: Goldman, Lee 12: Comprehensive Chronic Disease Management Edward H. Wagner Editor: Goldman, Lee Part 3: Preventive and Environmental Issues 13: Counseling and Advising for Behavior Changes F. Daniel Duffy Editor: Goldman, Lee 14: The Periodic Health Examination David Atkins Editor: Goldman, Lee 15: Physical Activity David M. Buchner Editor: Goldman, Lee 16: Adolescent Medicine Debra Katzman;Lawrence Neinstein Editor: Goldman, Lee 17: Immunization Walter Orenstein;William Atkinson Editor: Goldman, Lee 18: Principles of Occupational and Environmental Medicine Mark R. Cullen Editor: Goldman, Lee 19: Radiation Injury Arthur Upton Editor: Goldman, Lee 20: Bioterrorism John G. Bartlett Editor: Goldman, Lee 21: Chronic Poisoning: Trace Metals and Others Michael A McGuigan Editor: Goldman, Lee Part 4: Aging and Geriatric Medicine 22: Epidemiology of Aging: Implications of the Aging Society Linda Fried Editor: Goldman, Lee 23: Geriatric Assessment David B. Reuben Editor: Goldman, Lee 24: Common Clinical Sequelae of Aging Kenneth Minaker Editor: Goldman, Lee 25: Incontinence Neil Resnick Editor: Goldman, Lee 26: Neuropsychiatric Aspects of Aging Sharon Inouye Editor: Goldman, Lee 27: Delirium and Other Mental Status Problems in the Older Patient Sharon Inouye Editor: Goldman, Lee Part 5: Clinical Pharmacology 28: Principles of Drug Therapy Robert Diasio Editor: Schafer, Andrew 29: Pain Srinivasa N Raja;Steven P Cohen Editor: Schafer, Andrew 30: Biology of Addiction Steven E. Hyman Editor: Schafer, Andrew 31: Nicotine and Tobacco Tony P. George Editor: Schafer, Andrew 32: Alcohol Abuse and Dependence Patrick O'Connor Editor: Schafer, Andrew 33: Drug Abuse and Dependence Roger Weiss Editor: Schafer, Andrew 34: Immunosuppressive Drugs, Including Corticosteroids Grant Cannon Editor: Schafer, Andrew 35: Biologic Agents Cem Gabay Editor: Schafer, Andrew 36: Prostaglandins, Aspirin, and Related Compounds Carlo Patrono Editor: Schafer, Andrew 37: Antithrombotic Therapy Sam Schulman Editor: Schafer, Andrew 38: Complementary and Alternative Medicine Mary Charlson Editor: Schafer, Andrew Part 6: Genetics 39: Principles of Genetics Bruce Korf Editor: Schafer, Andrew 40: Single-Gene and Chromosome Disorders James R. Lupski Editor: Schafer, Andrew 41: The Inherited Basis of Common Diseases David Altshuler Editor: Schafer, Andrew 42: Applications of Molecular Technologies to Clinical Medicine Geoffrey Ginsburg;Geoffrey Ginsburg Editor: Schafer, Andrew 43: Gene and Cell Therapy Karl Skorecki Editor: Schafer, Andrew Part 7: Principles of Immunology and Inflammation 44: The Innate and Adaptive Immune Systems Cornelia Weyand;Jorg Goronzy Editor: Schafer, Andrew 45: The Major Histocompatibility Complex Peter K. Gregersen Editor: Schafer, Andrew 46: Mechanisms of Immune-Mediated Tissue Injury Jane Salmon Editor: Schafer, Andrew 47: Mechanisms of Inflammation and Tissue Repair Gary S. Firestein Editor: Schafer, Andrew 48: Organ Transplantation Megan Sykes Editor: Schafer, Andrew 49: Complement in Health and Disease David, R. Karp;V. Michael Holers Editor: Schafer, Andrew Part 8: Cardiovascular Disease 50: Approach to the Patient with Possible Cardiovascular Disease Lee Goldman Editor: Goldman, Lee 51: Epidemiology of Cardiovascular Disease Michael Klag Editor: Goldman, Lee 52: Cardiac Function and Circulatory Control Andrew Marks Editor: Goldman, Lee 53: Radiology of the Heart Murray G. Baron;Arthur E. Stillman Editor: Goldman, Lee 54: Electrocardiography Leonard I Ganz Editor: Goldman, Lee 55: Echocardiography Catherine Otto Editor: Goldman, Lee 56: Non-invasive Cardiac Imaging Christopher Kramer Editor: Goldman, Lee 57: Catheterization and Angiography Morton Kern Editor: Goldman, Lee 58: Heart Failure: Pathophysiology and Diagnosis Barry Massie Editor: Goldman, Lee 59: Heart Failure: Management and Prognosis John JV McMurray;Marc A. Pfeffer Editor: Goldman, Lee 60: Diseases of the Myocardium and Endocardium William McKenna;Perry Elliott Editor: Goldman, Lee 61: Principles of Electrophysiology Hugh Calkins Editor: Goldman, Lee 62: Approach to the Patient with Suspected Arrhythmia Jeffrey Olgin Editor: Goldman, Lee 63: Approach to Cardiac Arrest and Life-Threatening Arrhythmias Robert Myerburg Editor: Goldman, Lee 64: Cardiac Arrhythmias with Supraventricular Origin Peter Zimetbaum Editor: Goldman, Lee 65: Ventricular Arrhythmias William Stevenson Editor: Goldman, Lee 66: Electrophysiologic Interventional Procedures and Surgery Fred Morady Editor: Goldman, Lee 67: Arterial Hypertension Ronald Victor Editor: Goldman, Lee 68: Pulmonary Hypertension Valerie McLaughlin Editor: Goldman, Lee 69: Congenital Heart Disease in Adults Ariane Marelli Editor: Goldman, Lee 70: Atherosclerosis, Thrombosis and Vascular Biology Goran Hansson;Anders Hamsten Editor: Goldman, Lee 71: Angina Pectoris William Boden Editor: Goldman, Lee 72: Acute Coronary Syndrome/Unstable Angina and Non-ST Elevation MI Richard A. Lange Editor: Goldman, Lee 73: ST-Elevation Myocardial Infarction and Complications of MI Jeffrey Anderson Editor: Goldman, Lee 74: Interventional and Surgical Treatment of Coronary Artery Disease Paul Teirstein;Bruce Lytle Editor: Goldman, Lee 75: Valvular Heart Disease Blase Carabello Editor: Goldman, Lee 76: Infective Endocarditis Vance Fowler Jr.;Arnold Bayer Editor: Goldman, Lee 77: Pericardial Disease William Little;Jae K. Oh Editor: Goldman, Lee 78: Diseases of the Aorta Eric Isselbacher Editor: Goldman, Lee 79: Atherosclerotic Peripheral Arterial Disease Christopher White Editor: Goldman, Lee 80: Other Peripheral Arterial Diseases Jeffrey Olin Editor: Goldman, Lee 81: Peripheral Venous Disease Jeffrey Ginsberg Editor: Goldman, Lee 82: Cardiac Transplantation Mariell Jessup Editor: Goldman, Lee Part 9: Respiratory Diseases 83: Approach to the Patient with Respiratory Disease Monica Kraft Editor: Goldman, Lee 84: Imaging in Pulmonary Disease Paul Stark Editor: Goldman, Lee 85: Respiratory Structure and Function: Mechanisms and Testing Herbert Reynolds Editor: Goldman, Lee 86: Disorders of Ventilatory Control Atul Malhotra Editor: Goldman, Lee 87: Asthma Jeffrey Drazen Editor: Goldman, Lee 88: COPD Dennis Niewoehner Editor: Goldman, Lee 89: Cystic Fibrosis Frank Accurso Editor: Goldman, Lee 90: Bronchiectasis, Atelectasis, Cysts, and Localized Lung Disorders Anne O'Donnell Editor: Goldman, Lee 91: Alveolar Filling Disorders Stephanie, M. Levine Editor: Goldman, Lee 92: Interstitial Lung Disease Ganesh Raghu Editor: Goldman, Lee 93: Occupational Pulmonary Disorders Susan Tarlo Editor: Goldman, Lee 94: Physical and Chemical Injuries of the Lung David C. Christiani Editor: Goldman, Lee 95: Sarcoidosis Michael Iannuzzi Editor: Goldman, Lee 96: Acute Bronchitis and Tracheitis Richard. P. Wenzel Editor: Goldman, Lee 97: Overview of Pneumonia Andrew H. Limper Editor: Goldman, Lee 98: Pulmonary Embolism Jeffrey Weitz Editor: Goldman, Lee 99: Diseases of the Diaphragm, Chest Wall, Pleura, and Mediastinum F. Dennis McCool Editor: Goldman, Lee 100: Obstructive Sleep Apnea/Hypopnea Syndrome Robert C. Basner Editor: Goldman, Lee 101: Interventional and Surgical Approaches to Lung Disease Armin Ernst;Malcom DeCamp Editor: Goldman, Lee Part 10: Critical Care Medicine 102: Approach to the Patient in a Critical Care Setting Deborah J. Cook Editor: Goldman, Lee 103: Respiratory Monitoring in Critical Care James Stoller;Nicholas S. Hill Editor: Goldman, Lee 104: Acute Respiratory Failure Leonard Hudson;Arthur Slutsky Editor: Goldman, Lee 105: Mechanical Ventilation Leonard Hudson;Arthur Slutsky Editor: Goldman, Lee 106: Approach to the Patient with Shock Emanuel Rivers Editor: Goldman, Lee 107: Cardiogenic Shock Steven Hollenberg Editor: Goldman, Lee 108: Shock Syndromes Related to Sepsis James Russell Editor: Goldman, Lee 109: Disorders Due to Heat and Cold William Winkenwerder, Jr;Michael N Sawka Editor: Goldman, Lee 110: Acute Poisoning Marsha D. Ford I Editor: Goldman, Lee 111: Electric Injury Basil A. Pruitt Jr. Editor: Goldman, Lee 112: Medical Aspects of Trauma and Burn Care Robert H. Demling;Jonathan Gates;Reza Askari Editor: Goldman, Lee 113: Venomous Snake Bites Steven A. Seifert;James Armitage Editor: Goldman, Lee 114: Venoms and Poisons from Marine Organisms Jay Fox Editor: Goldman, Lee 115: Rhabdomyolysis Francis O'Connor;Patricia A. Deuster Editor: Goldman, Lee Part 11: Renal and Genitourinary Diseases 116: Approach to the Patient with Renal Disease Donald Landry Editor: Goldman, Lee 117: Structure and Function of the Kidneys Qais Al-Awqati;Jonathan Barasch Editor: Goldman, Lee 118: Disorders of Sodium and Water Homeostasis Karl Skorecki;Denny Ausiello Editor: Goldman, Lee 119: Potassium Disorders Julian Seifter Editor: Goldman, Lee 120: Acid-Base Disorders Julian Seifter Editor: Goldman, Lee 121: Disorders of Magnesium and Phosphorus Alan S. L. Yu Editor: Goldman, Lee 122: Acute Kidney Injury Bruce Molitoris Editor: Goldman, Lee 123: Glomerular Disorders and Nephrotic Syndromes Gerald B. Appel;Jai Radhakrishnan Editor: Goldman, Lee 124: Tubulointerstitial Diseases Eric G Neilson Editor: Goldman, Lee 125: Obstructive Uropathy Mark Zeidel Editor: Goldman, Lee 126: Diabetes and the Kidney Raymond Harris Editor: Goldman, Lee 127: Vascular Disorders of the Kidney Thomas D. DuBose, Jr. Editor: Goldman, Lee 128: Nephrolithiasis Gary C Curhan Editor: Goldman, Lee 129: Cystic Kidney Diseases M. Amin Arnaout Editor: Goldman, Lee 130: Hereditary Nephropathies and Abnormalities of the Urinary Tract Lisa Guay-Woodford Editor: Goldman, Lee 131: Benign Prostate Disease and Prostatitis Michael Barry;Mary McNaughton-Collins Editor: Goldman, Lee 132: Chronic Kidney Disease William Mitch Editor: Goldman, Lee 133: Treatment of Irreversible Renal Failure Nina Tolkoff-Rubin Editor: Goldman, Lee Part 12:Gastrointestinal Diseases 134: Approach to the Patient with Gastrointestinal Disease Kenneth McQuaid Editor: Goldman, Lee 135: Diagnostic Imaging Procedures in Gastroenterology Perry J Pickhardt Editor: Goldman, Lee 136: Gastrointestinal Endoscopy P. Jay Pasricha Editor: Goldman, Lee 137: Gastrointestinal Hemorrhage and Occult Gastrointestinal Bleeding Dennis M. Jensen Editor: Goldman, Lee 138: Disorders of Gastrointestinal Motility Michael Camilleri Editor: Goldman, Lee 139: Functional Gastrointestinal Disorders: Irritable Bowel Syndrome, Dyspepsia, and Noncardiac Chest Pain Emeran Mayer Editor: Goldman, Lee 140: Diseases of the Esophagus David A. Katzka;Gary Falk Editor: Goldman, Lee 141: Acid Peptic Disease Ernst Kuipers;Martin Blaser Editor: Goldman, Lee 142: Approach to the Patient with Diarrhea and Malabsorption Carol E. Semrad Editor: Goldman, Lee 143: Inflammatory Bowel Disease Gary R. Lichtenstein Editor: Goldman, Lee 144: Inflammatory and Anatomic Diseases of theINtestine, Peritoneum, Mesentery, and Omentum Charlene Prather Editor: Goldman, Lee 145: Vascular Diseases of the GI Tract Stephen Hauser Editor: Goldman, Lee 146: Pancreatitis Chris E. Forsmark Editor: Goldman, Lee 147: Diseases of the Rectum and Anus Robert D. Madoff Editor: Goldman, Lee Part 13: Diseases of the Liver, Gallbladder, and Bile Ducts 148: Approach to the Patient with Liver Disease Paul Martin Editor: Goldman, Lee 149: Approach to the Patient with Jaundice or Abnormal Liver Test Results Paul Berk;Kevin Korenblat Editor: Goldman, Lee 150: Acute Viral Hepatitis Jean-Michel Pawlotsky;Heiner Wedemeyer Editor: Goldman, Lee 151: Chronic Viral Hepatitis Jean-Michel Pawlotsky;John McHutchinson Editor: Goldman, Lee 152: Toxin- and Drug-Induced Liver Disease William Lee Editor: Goldman, Lee 153: Inherited and Metabolic Hepatic Disorders Bruce R Bacon Editor: Goldman, Lee 154: Bacterial, Parasitic, Fungal, and Granulomatous Liver Diseases Karen Krok;K. Rajender Reddy Editor: Goldman, Lee 155: Alcoholic and NonAlcoholic Steatohepatitis Naga P. Chalasani Editor: Goldman, Lee 156: Cirrhosis and Its Sequelae Guadalupe Garcia-Tsao Editor: Goldman, Lee 157: Hepatic Failure and Liver Transplantation Emmet Keeffe Editor: Goldman, Lee 158: Diseases of the Gallbladder and Bile Ducts Nezam H. Afdhal Editor: Goldman, Lee Part 14: Hematologic Diseases 159: Hematopoiesis and Hematopoietic Growth Factors Kenneth Kaushansky Editor: Schafer, Andrew 160: The Peripheral blood Smear Barbara Bain Editor: Schafer, Andrew 161: Approach to the Anemias H. Franklin Bunn Editor: Schafer, Andrew 162: Microcytic and Hypochromic Anemias Gordon Ginder Editor: Schafer, Andrew 163: Autoimmune and Intravascular Hemolytic Anemias Robert Schwartz Editor: Schafer, Andrew 164: Hemolytic Anemias: Red Cell Membrane and Metabolic Defects Patrick Gallagher Editor: Schafer, Andrew 165: Hemoglobinopathies: The Thalassemias Maria Cappellini Editor: Schafer, Andrew 166: Sickle Cell Disease and Associated Hemoglobinopathies Martin Steinberg Editor: Schafer, Andrew 167: Megaloblastic Anemias Asok C. Antony Editor: Schafer, Andrew 168: Aplastic Anemia and Related Conditions Grover Bagby Editor: Schafer, Andrew 169: Polycythemias, Essential Thrombocythemia and Primary Myelobfibrosis Ayalew Tefferi Editor: Schafer, Andrew 170: Leukopenia and Leukocytosis Nancy Berliner Editor: Schafer, Andrew 171: Approach to the Patient with Lymphadenopathy and Splenomegaly James Armitage Editor: Schafer, Andrew 172: Disorders of Phagocyte Function Michael Glogauer Editor: Schafer, Andrew 173: Eosinophilic Syndromes Marc Rothenberg Editor: Schafer, Andrew 174: Approach to the Patient with Bleeding and Thrombosis Andrew Schafer Editor: Schafer, Andrew 175: Thrombocytopenia Charles Abrams Editor: Schafer, Andrew 176: Von Willebrand's Disease and Abnormalties of Vascular Function William Nichols Editor: Schafer, Andrew 177: Hemorrhagic Disorders: Coagulation Factor Deficiencies Margaret Ragni Editor: Schafer, Andrew 178: Hemorrhagic Disorders: DIC, Liver Failure, and Vitamin K Deficiency Andrew Schafer Editor: Schafer, Andrew 179: Thrombotic Disorders: Hypercoagulable States Andrew Schafer Editor: Schafer, Andrew 180: Transfusion Medicine Lawrence Goodnough Editor: Schafer, Andrew 181: Hematopoietic Stem Cell Transplantation Julie Vose Editor: Schafer, Andrew Part 15: Oncology 182: Approach to the Patient with Cancer Michael Perry Editor: Schafer, Andrew 183: The Epidemiology of Cancer Michael Thun Editor: Schafer, Andrew 184: The Genetics of Cancer Henry Lynch Editor: Schafer, Andrew 185: The Biology of Cancer Kenneth H Cowan;Jeffrey A Moscow Editor: Schafer, Andrew 186: Endocrine Manifestations of Tumors: "Ectopic" Hormone Production Robert F. Gagel Editor: Schafer, Andrew 187: Paraneoplastic Syndromes and Other Non-Neoplastic Effects of Cancer Hope Rugo Editor: Schafer, Andrew 188: Myelodysplasia Syndrome Alan List;Rami Komrokji;Eric Padron Editor: Schafer, Andrew 189: The Acute Leukemias Frederick R Appelbaum Editor: Schafer, Andrew 190: The Chronic Leukemias Hagop Kantarjian;Susan O'Brien Editor: Schafer, Andrew 191: Non-Hodgkin's Lymphomas James Armitage Editor: Schafer, Andrew 192: Hodgkin's Lymphomas Joseph Connors Editor: Schafer, Andrew 193: Plasma Cell Disorders S. Vincent Rajkumar Editor: Schafer, Andrew 194: Amyloidosis Morrie Gertz Editor: Schafer, Andrew 195: Tumors of the CNS and Intracranial Hypertension and Hypotension Lisa DeAngelis Editor: Schafer, Andrew 196: Head and Neck Cancer Marshall R. Posner Editor: Schafer, Andrew 197: Lung Cancer and Other Pulmonary Neoplasms David S Ettinger Editor: Schafer, Andrew 198: Neoplasma of the Esophagus and Stomach Anil Rustgi Editor: Schafer, Andrew 199: Neoplasms of the Large and Small Intestine Charles Blanke;Douglas Faigel Editor: Schafer, Andrew 200: Pancreatic Cancer Margaret Tempero Editor: Schafer, Andrew 201: Pancreatic Endocrine Tumors Robert T. Jensen Editor: Schafer, Andrew 202: Liver and Biliary Tract Tumors Lewis Roberts Editor: Schafer, Andrew 203: Tumors of the Kidney, Bladder, Ureters, and Renal Pelvis Dean Bajorin Editor: Schafer, Andrew 204: Breast Cancer and Differential Diagnosis of Benign Lesions Nancy Davidson Editor: Schafer, Andrew 205: Gynecologic Cancers Maurie Markman Editor: Schafer, Andrew 206: Testicular Cancer Lawrence Einhorn Editor: Schafer, Andrew 207: Prostate Cancer Eric Small Editor: Schafer, Andrew 208: Bone Tumors: Primary and Metastatic Lesions Karen H. Antman Editor: Schafer, Andrew 209: Sarcomas of Soft Tissue George D. Demetri Editor: Schafer, Andrew 210: Melanoma and Nonmelanoma Skin Cancers Lynn Schuchter Editor: Schafer, Andrew 211: Cancer of Unknown Primary Origin John Hainsworth Editor: Schafer, Andrew Part 16: Metabolic Diseases 212: Approach to Inborn Errors of Metabolism Louis Elsas II Editor: Schafer, Andrew 213: Disorders of Lipid Metabolism Clay F. Semenkovich Editor: Schafer, Andrew 214: Glycogen Storage Diseases Joseph I. Wolfsdorf;David A. Weinstein Editor: Schafer, Andrew 215: Lysosomal Storage Diseases Ellen Sidransky;Donna Krasnewich Editor: Schafer, Andrew 216: Homocystinuria and Hyperhomocysteinemia Bruce Barshop Editor: Schafer, Andrew 217: The Porphyrias Karl Anderson Editor: Schafer, Andrew 218: Wilson's Disease Stephen Kaler Editor: Schafer, Andrew 219: Iron Overload (Hemochromatosis) Bruce R Bacon Editor: Schafer, Andrew Part 17:Nutritional Diseases 220: Nutrition's Interface with Health and Disease Douglas Heimburger Editor: Schafer, Andrew 221: Nutritional Assessment Bruce Bistrian Editor: Schafer, Andrew 222: Protein-Energy Malnutrition Samuel Klein Editor: Schafer, Andrew 223: Enteral Nutrition Stephen McClave Editor: Schafer, Andrew 224: Parenteral Nutrition Greet Van den Berghe;Alexander Wilmer Editor: Schafer, Andrew 225: Vitamins, Trace Minerals, and Other Micronutrients Joel B. Mason Editor: Schafer, Andrew 226: Eating Disorders Marsha Marcus Editor: Schafer, Andrew 227: Obesity Michael Jensen Editor: Schafer, Andrew Part 18: Endocrine Diseases 228: Approach to the Patient with Endocrine Disease David R. Clemmons Editor: Schafer, Andrew 229: Principles of Endocrinology David R. Clemmons Editor: Schafer, Andrew 230: Neuroendocrinology and the Neuroendocrine System Mark E. Molitch Editor: Schafer, Andrew 231: Anterior Pituitary Mark E. Molitch Editor: Schafer, Andrew 232: Posterior Pituitary Joseph G. Verbalis Editor: Schafer, Andrew 233: Thyroid Paul Ladenson;Matthew Kim Editor: Schafer, Andrew 234: Adrenal Cortex Lynnette Nieman Editor: Schafer, Andrew 235: The Adrenal Medulla, Catecholamines, and Pheochromocytoma William F. Young Editor: Schafer, Andrew 236: Type I Diabetes Mellitus Robert Sherwin;Silvio Inzucchi Editor: Schafer, Andrew 237: Type II Diabetes Mellitus Robert Sherwin;Silvio Inzucchi Editor: Schafer, Andrew 238: Hypoglycemia/Pancreatic Islet Cell Disorders Stephen N. Davis Editor: Schafer, Andrew 239: Polyglandular Disorders Henry Kronenberg Editor: Schafer, Andrew 240: Multiple-Organ Syndromes: Carcinoid Syndrome Kenneth Hande Editor: Schafer, Andrew 241: Disorders of Sexual Differentiation Perrin C. White Editor: Schafer, Andrew 242: The Testis and Male Sexual Function Ronald Swerdloff Editor: Schafer, Andrew 243: Ovaries, Development and Menstrual Cycle Robert W Rebar Editor: Schafer, Andrew 244: Reproductive Endocrinology/Infertility Robert W Rebar Editor: Schafer, Andrew Part 19: Women's Health 245: Approach to Women's Health Karen Freund Editor: Schafer, Andrew 246: Contraception Daniel Mishell Jr. Editor: Schafer, Andrew 247: Common Medical Problems in Pregnancy Karen Rosene Montella Editor: Schafer, Andrew 248: Menopause Deborah Grady;Elizabeth Barrett-Connor Editor: Schafer, Andrew 249: Interpersonal Violence Harriet MacMillan;Gene Feder Editor: Schafer, Andrew Part 20: Diseases of Bone and Mineral Metabolism 250: Mineral and Bone Homeostasis Murray Favus Editor: Schafer, Andrew 251: Osteoporosis Cliff Rosen Editor: Schafer, Andrew 252: Osteomalacia and Rickets Robert Weinstein Editor: Schafer, Andrew 253: The Parathyroid Glands, Hypercalcemia, and Hypocalcemia John Wysolmerski;Karl Insogna Editor: Schafer, Andrew 254: Medullary Thyroid Carcinoma and Calcitonin Samuel Wells Jr. Editor: Schafer, Andrew 255: Paget's Disease of Bone David Roodman Editor: Schafer, Andrew 256: Osteonecrosis, Osteosclerosis/Hyperostosis and Other Disorders of Bone Michael P. Whyte Editor: Schafer, Andrew Part 21: Diseases of Allergy and Clinical Immunology 257: Approach to the Patient with Allergic or Immunologic Disease Stephen I Wasserman Editor: Schafer, Andrew 258: Primary Immunodeficiency Diseases Mark Ballow Editor: Schafer, Andrew 259: Allergic Rhinitis and Sinusitis Larry Borish Editor: Schafer, Andrew 260: Urticaria and Angioedema Stephen Dreskin Editor: Schafer, Andrew 261: Systemic Anaphylaxis, Food Allergy, and Insect Sting Allergy Lawrence Schwartz Editor: Schafer, Andrew 262: Drug Allergy Leslie Grammer Editor: Schafer, Andrew 263: Mastocytosis Cem Akin Editor: Schafer, Andrew Part 22: Rheumatic Diseases 264: Approach to the Patient with Rheumatic Disease William Arend;George Lawry Editor: Schafer, Andrew 265: Laboratory Testing in the Rheumatic Diseases David Pisetsky Editor: Schafer, Andrew 266: Imaging Studies in the Rheumatic Diseases Lynne Steinbach Editor: Schafer, Andrew 267: Connective Tissue Structure and Function Richard Loeser Editor: Schafer, Andrew 268: Inherited Diseases of Connective Tissues Reed Edwin Pyeritz Editor: Schafer, Andrew 269: The Systemic Autoinflammatory Diseases Daniel Kastner Editor: Schafer, Andrew 270: Osteoarthritis Nancy Lane;Thomas J. Schnitzer Editor: Schafer, Andrew 271: Bursitis, Tendonitis, and Other Periarticular Disorders, and Sports Medicine Josephn J. Biundo Editor: Schafer, Andrew 272: Rheumatoid Arthritis James O'Dell Editor: Schafer, Andrew 273: The Spondyloarthropathies Robert Inman Editor: Schafer, Andrew 274: Systemic Lupus Erythematosus Mary Crow Editor: Schafer, Andrew 275: Scleroderma (Systemic Sclerosis) John Varga Editor: Schafer, Andrew 276: Sjogren's Syndrome M. Eric Gershwin;Stanley Naguwa Editor: Schafer, Andrew 277: Polymyositis and Dermatomyositis Frederick, W. Miller Editor: Schafer, Andrew 278: The Systemic Vasculitides John, H Stone Editor: Schafer, Andrew 279: Polymyalgia Rheumatica and Temporal Arteritis Steven Paget;Robert Spiera Editor: Schafer, Andrew 280: Infections of Bursae, Joints, and Bones Eric Matteson;Douglas Osmon Editor: Schafer, Andrew 281: Crystal Deposition Diseases N.Lawrence Edwards Editor: Schafer, Andrew 282: Fibromyalgia and Chronic Fatigue Syndrome Robert Bennett Editor: Schafer, Andrew 283: Systemic Diseases in which Arthritis is a Feature Sterling,G. West Editor: Schafer, Andrew 284: Multifocal Fibrosclerosis Wilmer Sibbitt Jr. Editor: Schafer, Andrew 285: Surgical Treatment of Joint Diseases C. Ronald Mackenzie;Edwin Su Editor: Schafer, Andrew Part 23: Infectious Diseases 286: Introduction to Microbial Disease - Host-Pathogen Interactions William Scheld Editor: Schafer, Andrew 287: Principles of Anti-Infective Therapy George M. Eliopoulos Editor: Schafer, Andrew 288: Approach to Fever or Suspected Infection in the Normal Host James Leggett Editor: Schafer, Andrew 289: Approach to Fever and Suspected Infection in the Compromised Host Kieren Marr Editor: Schafer, Andrew 290: Approach to the Patient with Healthcare-associated Infections Neil Fishman Editor: Schafer, Andrew 291: Approach to the Patient with Suspected Enteric Infection Herbert DuPont Editor: Schafer, Andrew 292: Approach to the Patient with Urinary Tract Infection Ragnar Norrby Editor: Schafer, Andrew 293: Approach to the Patient with a Sexually Transmitted Disease Myron S. Cohen Editor: Schafer, Andrew 294: Approach to the Patient Before and After Travel Paul, M. Arguin Editor: Schafer, Andrew 295: Antibacterial Therapy George Drusano Editor: Schafer, Andrew 296: Staphylococcal Infections Henry Chambers Editor: Schafer, Andrew 297: Streptococcus Pneumoniae Infections Lionel Mandell Editor: Schafer, Andrew 298: Non-Pneumococcal Streptococcal Infections, Rheumatic Fever Donald Low Editor: Schafer, Andrew 299: Enterococcal Infections Trish Perl;Eli N. Perencevich Editor: Schafer, Andrew 300: Diphtheria and Other Corynebacteria Infections Roland Sutter Editor: Schafer, Andrew 301: Listeriosis Bennett Lorber Editor: Schafer, Andrew 302: Anthrax Daniel Lucey Editor: Schafer, Andrew 303: Erysipelothrix Infections Annette C. Reboli Editor: Schafer, Andrew 304: Clostridial Infections Dale Gerding Editor: Schafer, Andrew 305: Diseases Caused by Non-spore-forming Anaerobic Bacteria Itzhak Brook Editor: Schafer, Andrew 306: Neisseria Meningitidis Infections David Stephens Editor: Schafer, Andrew 307: Neisseria Gonorhoeaea Infections Matthew Golden Editor: Schafer, Andrew 308: Haemophilus and Moraxella Infections Michael Simberkoff Editor: Schafer, Andrew 309: Chancroid Stanley Spinola Editor: Schafer, Andrew 310: Cholera and Other Vibrio Infections Carlos Seas Editor: Schafer, Andrew 311: Campylobacter Infections Ban Mishu Allos Editor: Schafer, Andrew 312: Escherichia Enteric Infections Richard Guerrant;Ted Steiner Editor: Schafer, Andrew 313: Infections due to other Members of the Enterobacteriaceae, including Management of Multi-Drug Resistant Strains David Paterson Editor: Schafer, Andrew 314: Pseudomonas and Related Gram-Negative Bacillary Infections Gerald Pier Editor: Schafer, Andrew 315: Other Non-Fermenting Gram-Negatives: Acinetobacter and Stenotrophomonas sp Robert Bonomo Editor: Schafer, Andrew 316: Salmonella Infections (Including Typhoid Fever) John A. Crump Editor: Schafer, Andrew 317: Shigellosis Gerald T. Keusch Editor: Schafer, Andrew 318: Brucellosis Eduardo Gotuzzo Editor: Schafer, Andrew 319: Tularemia and Other Francisella Infections William Schaffner Editor: Schafer, Andrew 320: Plague and Other Yersinia Infections Kenneth Gage Editor: Schafer, Andrew 321: Whooping Cough and Other Bordetella Infections Erik L. Hewlett Editor: Schafer, Andrew 322: Legionella Infections Thomas Marrie Editor: Schafer, Andrew 323: Disease Caused by Bartonella Species Didier Raoult;Jean-Marc Rolain Editor: Schafer, Andrew 324: Granuloma Inguinale (Donovanosis) Edward W. Hook III Editor: Schafer, Andrew 325: Mycoplasma Infections Stephen G. Baum Editor: Schafer, Andrew 326: Diseases Caused by Chlamydiae William, M. Geisler Editor: Schafer, Andrew 327: Treponema Infection (Syphillis) Edward W. Hook III Editor: Schafer, Andrew 328: Nonsyphilitic Treponematoses Edward W. Hook III Editor: Schafer, Andrew 329: Lyme Disease Gary Wormser Editor: Schafer, Andrew 330: Relapsing Fever and Other Borrelia Infections William Petri Editor: Schafer, Andrew 331: Leptospirosis Albert Ko Editor: Schafer, Andrew 332: Tuberculosis Jerrold Ellner Editor: Schafer, Andrew 333: The Nontuberculous Mycobacteria Steven Holland Editor: Schafer, Andrew 334: Leprosy (Hansen's Disease) Joel Ernst Editor: Schafer, Andrew 335: Rickettsia Infections Didier Raoult Editor: Schafer, Andrew 336: Zoonoses Stuart Levin Editor: Schafer, Andrew 337: Actinomycosis Itzhak Brook Editor: Schafer, Andrew 338: Nocardiosis Frederick Southwick Editor: Schafer, Andrew 339: Systemic Antifungal Agents David A. Stevens Editor: Schafer, Andrew 340: Histoplasmosis Carol Kauffman Editor: Schafer, Andrew 341: Coccidioidomycosis John N. Galgiani Editor: Schafer, Andrew 342: Blastomycosis Carol Kauffman Editor: Schafer, Andrew 343: Paracoccidioidomycosis Carol Kauffman Editor: Schafer, Andrew 344: Cryptococcoisis Carol Kauffman Editor: Schafer, Andrew 345: Sporotrichosis Carol Kauffman Editor: Schafer, Andrew 346: Candidiasis Carol Kauffman Editor: Schafer, Andrew 347: Aspergillosis Thomas Walsh Editor: Schafer, Andrew 348: Mucormycosis Dimitrios Kontoyiannis Editor: Schafer, Andrew 349: Pneumocystis Penumonia Joseph A. Kovacs Editor: Schafer, Andrew 350: Mycetoma Dimitrios Kontoyiannis Editor: Schafer, Andrew 351: Dematiaceous Fungal Infections Peter Pappas Editor: Schafer, Andrew 352: Antiparasitic Therapy Richard Pearson Editor: Schafer, Andrew 353: Malaria Philip Rosenthal;Moses R. Kamya Editor: Schafer, Andrew 354: African Trypanosomiasis (Sleeping Sickness) William Petri Editor: Schafer, Andrew 355: American Trypanosomiasis (Chagas' Disease) Louis V. Kirchhoff Editor: Schafer, Andrew 356: Leishmaniasis Simon Croft Editor: Schafer, Andrew 357: Toxoplasmosis Jose, G Montoya Editor: Schafer, Andrew 358: Crytosporidiosis Richard Guerrant;Aldo A. M. Lima Editor: Schafer, Andrew 359: Giardiasis Theodore E. Nash Editor: Schafer, Andrew 360: Amebiasis William Petri Editor: Schafer, Andrew 361: Babesiosis and Other Protozoan Diseases Sam Telford III Editor: Schafer, Andrew 362: Cestode Infections A. Clinton White;Enrico Brunetti Editor: Schafer, Andrew 363: Schistosomiasis (Bilharziasis) Aldo A. M. Lima;Edgar Carvalho Editor: Schafer, Andrew 364: Liver, Intestinal, and Lung Fluke Infections Eduardo Gotuzzo Editor: Schafer, Andrew 365: Intestinal Nematodes David Diemert Editor: Schafer, Andrew 366: Tissue Nematodes David Diemert Editor: Schafer, Andrew 367: Arthropods and Leeches Dirk Elston Editor: Schafer, Andrew 368: Antiviral Therapy (Non-HIV) John Beigel Editor: Goldman, Lee 369: The Common Cold Ronald B. Turner Editor: Goldman, Lee 370: Respiratory Syncytial Virus Edward Walsh Editor: Goldman, Lee 371: Parainfluenza Viral Diseases Kathryn Edwards;Geoffrey A. Weinberg Editor: Goldman, Lee 372: Influenza Frederick Hayden Editor: Goldman, Lee 373: Adenovirus Diseases John J. Treanor Editor: Goldman, Lee 374: Coronaviruses Larry Anderson Editor: Goldman, Lee 375: Measles (Rubeola Virus Infection) Marty Weisse;Capt. Mark Papania Editor: Goldman, Lee 376: Rubella (German Measles) Susan Reef Editor: Goldman, Lee 377: Mumps John Gnann Editor: Goldman, Lee 378: Slow Virus Infections Avindra Nath Editor: Goldman, Lee 379: Parvovirus Neal S. Young Editor: Goldman, Lee 380: Smallpox, Monkeypox, and Other Poxvirus Infections Inger Damon Editor: Goldman, Lee 381: Papillomavirus John M. Douglas Jr. Editor: Goldman, Lee 382: Herpes Simplex Virus Infections Richard J. Whitley Editor: Goldman, Lee 383: Varicella (Chickenpox, Shingles) Jeffrey Cohen Editor: Goldman, Lee 384: Cytomegalovirus W. Lawrence Drew Editor: Goldman, Lee 385: Epstein-Barr Virus Infection Robert Schooley Editor: Goldman, Lee 386: Human T-Cell Lymphotropic Viruses Type I and II William Blattner Editor: Goldman, Lee 387: Enteroviruses Jose R Romero Editor: Goldman, Lee 388: Rotaviruses, Noroviruses, and Other GI Viruses Harry Greenberg;Manuel Franco Editor: Goldman, Lee 389: Viral Hemorrhagic Fevers Daniel G. Bausch Editor: Goldman, Lee 390: Arthropod-borne Viruses Causing Fever and Rash Stanley Naides Editor: Goldman, Lee 391: Anthropod-borne Viruses Affecting the CNS Thomas Bleck Editor: Goldman, Lee Part 24: HIV and the Acquired Immunodeficiency Syndrome 392: Epidemiology of HIV Infection and AIDS Thomas Quinn Editor: Schafer, Andrew 393: Immunopathogenesis of HIV Infection Robert Siliciano Editor: Schafer, Andrew 394: Biology of Human Immunodeficiency Viruses George Shaw Editor: Schafer, Andrew 395: Prevention of HIV Infection Carlos Del Rio Editor: Schafer, Andrew 396: Treatment of HIV Infection and AIDS Henry Masur Editor: Schafer, Andrew 397: Gastrointestinal Manifestions of HIV and AIDS Christine Wanke;Tamsin Knox Editor: Schafer, Andrew 398: Pulmonary Manifestations of HIV and AIDS Laurence Huang Editor: Schafer, Andrew 399: Skin Manifestations in Patients with HIV Infection Toby Maurer Editor: Schafer, Andrew 400: Hematology/Oncology in Patients with HIV Infection Paul A. Volberding Editor: Schafer, Andrew 401: Neurologic Complications of HIV Infection Avindra Nath Editor: Schafer, Andrew 402: Immune reconstitution Inflammatory Syndrome in HIV/AIDS Robert Colebunders;Martyn French Editor: Schafer, Andrew Part 25: Neurology 403: Approach to the Patient with Neurological Disease Ralph Jozefowicz;Michael Aminoff Editor: Goldman, Lee 404: Psychiatric Disorders in Medical Practice Jeffrey M. Lyness Editor: Goldman, Lee 405: Headaches and Other Head Pain Kathleen Digre Editor: Goldman, Lee 406: Head and Spinal Cord Injury Geoffrey Ling Editor: Goldman, Lee 407: Spine, Disc, Spinal Cord and Spinal Root Disease Richard, L Barbano Editor: Goldman, Lee 408: Regional Cerebral Dysfunction David Knopman Editor: Goldman, Lee 409: Alzheimer's Disease and Other Dementias David Knopman Editor: Goldman, Lee 410: The Epilepsies Samuel Wiebe Editor: Goldman, Lee 411: Coma, Persistent Vegetative State and Brain Death James L. Bernat Editor: Goldman, Lee 412: Disorders of Sleep Mark W. Mahowald Editor: Goldman, Lee 413: Approach to Cerebrovascular Diseases Justin Zivin Editor: Goldman, Lee 414: Ischemic Cerebrovascular Disease Justin Zivin Editor: Goldman, Lee 415: Hemorrhagic Cerebrovascular Disease Justin Zivin Editor: Goldman, Lee 416: Parkinsonism Anthony E Lang Editor: Goldman, Lee 417: Other Movement Disorders Anthony Lang Editor: Goldman, Lee 418: ALS and Other Motor Neuron Diseases Pamela J Shaw Editor: Goldman, Lee 419: Multiple Sclerosis and Demyelinating Conditions of the CNS Peter Calabresi Editor: Goldman, Lee 420: Meningitis: Bacterial, Viral, and Other Avindra Nath Editor: Goldman, Lee 421: Brain Abscess and Parameningeal Infections Avindra Nath;Joseph, R Berger Editor: Goldman, Lee 422: Acute Viral Encephalitis Allen Aksamit Jr. Editor: Goldman, Lee 423: Poliomyelitis Allen Aksamit Jr. Editor: Goldman, Lee 424: Prion Diseases Patrick J. Bosque Editor: Goldman, Lee 425: Nutritional and Alcohol-Related Neurologic Diseases Barbara Koppel Editor: Goldman, Lee 426: Congenital, Developmental and Neurocutaneous Disorders Jonathan W. Mink Editor: Goldman, Lee 427: Autonomic Disorders and Their Management William P. Cheshire Jr. Editor: Goldman, Lee 428: Peripheral Neuropathies Michael Shy Editor: Goldman, Lee 429: Muscle Diseases Patrick F. Chinnery Editor: Goldman, Lee 430: Disorders of Neuromuscular Transmission Angela Vincent Editor: Goldman, Lee Part 26: Eye, Ear, Nose, and Throat Diseases 431: Diseases of the Visual System Myron Yanoff;J. Douglas Cameron Editor: Goldman, Lee 432: Neuro-Ophthalmology Robert W. Baloh;Joanna Jen Editor: Goldman, Lee 433: Diseases of the Mouth and Salivary Glands Troy Daniels Editor: Goldman, Lee 434: Approach to the Patient with Nose, Sinus, and Ear Disorders Andrew Murr Editor: Goldman, Lee 435: Smell and Taste Robert W. Baloh;Joanna Jen Editor: Goldman, Lee 436: Hearing and Equilibrium Robert W. Baloh;Joanna Jen Editor: Goldman, Lee 437: Throat Disorders Thomas Tami Editor: Goldman, Lee Part 27: Medical Consultation 438: Principles of Preoperative Consultation and Co-Management Gerald Smetana Editor: Goldman, Lee 439: Preoperative Evaluation Steven Cohn Editor: Goldman, Lee 440: Overview of Anesthesia Jeanine Wiener-Kronish;Lee Fleisher Editor: Goldman, Lee 441: Postoperative Care and Complications Don Redelmeier Editor: Goldman, Lee 442: Medical Consultation in Psychiatry Peter Manu Editor: Goldman, Lee Part 28: Skin Diseases 443: Structure and Function of Skin David Norris Editor: Goldman, Lee 444: Examination of the Skin and an Approach to Diagnosing Skin Diseases Cheryl Armstrong Editor: Goldman, Lee 445: Principles of Therapy Victoria Werth Editor: Goldman, Lee 446: Eczema, Photosensitivity, and papulosquamous (including fungal) Diseases and Figurate Erythemas Henry Lim Editor: Goldman, Lee 447: Macular, Vesiculobullous, and Pustular Diseases Neil Korman Editor: Goldman, Lee 448: Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases Madeleine Duvic Editor: Goldman, Lee 449: Infections, Hyper-and Hypopigmentation, Regional Dermatology, and Distinctive Lesions in Black Skin Jean Bolognia Editor: Goldman, Lee 450: Diseases of Hair and Nails Antonella Tosti Editor: Goldman, Lee Appendix: Laboratory Reference Intervals and Values Appendix: Reference Intervals and Laboratory Values Ronald J. Elin Editor: Goldman, Lee

About the Author

Executive Vice President for Health and Biomedical Sciences and Dean of the Faculties of Health Sciences and of Medicine, Harold and Margaret Hatch Professor of the University, Professor of Medicine and of Epidemiology, Columbia University, New York, NY

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