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Glycobiology of the Immune Response (Annals of the New York Academy of Sciences)

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Home » Books » Science » Biology » Biochemistry

Glycobiology of the Immune Response

Annals of the New York Academy of Sciences

By Gabriel Rabinovich (Edited by), Brian Cobb (Edited by), Yvette van Kooyk (Edited by)

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Format: Paperback, 252 pages
Other Information: Illustrations (some col.).
Published In: United States, 11 May 2012
Carbohydrates are ubiquitous, essential molecules, as important as nucleic acids and proteins yet less well understood. Mounting data demonstrate that microbial and mammalian glycans and their protein-binding partners (lectins) play central roles in all innate and adaptive immune responses. Indeed, programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. Glycobiology of the Immune Response explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order ( Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit for more information about becoming a member.

Table of Contents

Glycobiology of immune responses 1 Gabriel A. Rabinovich, Yvette van Kooyk and Brian A. Cobb Multifarious roles of sialic acids in immunity 16 Ajit Varki and Pascal Gagneux Siglecs as sensors of self in innate and adaptive immune responses 37 James C. Paulson, Matthew S. Macauley and Norihito Kawasaki Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation 49 Ari Grigorian, Haik Mkhikian and Michael Demetriou T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival 58 Mary C. Clark and Linda G. Baum Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells 68 Bo Pei, Jose Luis Vella, Dirk Zajonc and Mitchell Kronenberg Gelectins in acute and chronic inflammation 80 Fu-Tong Liu, Ri-Yao Yang and Daniel K. Hsu Mechanisms underlying in vivo polysaccharide-specific immunoglobulin responses to intact extracellular bacteria 92 Clifford M. Snapper CD33-related siglecs as potential modulators of inflammatory responses 102 Paul R. Crocker, Sarah J. McMillan and Hannah E. Richards Sulfated glycans control lymphocyte homing 112 Hiroto Kawashima and Minoru Fukuda Acute phase glycoproteins: bystanders or participants in carcinogenesis? 122 Eugene Dempsey and Pauline M. Rudd Glycans, galectins, and HIV-1 infection 133 Sachiko Sato, Michel Ouellet, Christian St-Pierre and Michel J. Tremblay An evolutionary perspective on C-type lectins in infection and immunity 149 Linda M. van den Berg, Sonja I. Gringhuis and Teunis B. H. Geijtenbeck Integrated approach toward the discovery of glycol-biomarkers of inflammation-related diseases 159 Takashi Angata, Reiko Fuijinawa, Ayako Kurimoto, Kazuki Nakajima, Masaki Kato, Shinji Takamatsu, Hiroaki Korekane, Cong-Xiao Gao, Kazuaki Ohtsubo, Shinobu Kitazume and Naoyuki Taniguchi Novel roles for the IgG Fc Glycan 170 Robert M. Anthony, Fredrik Wermeling and Jeffrey V. Ravetch The effect of galectins on leukocyte trafficking in inflammation: sweet or sour? 181 Dianne Cooper, Asif J. Iqbal, Beatrice R, Grittens, Carmela Cervone and Mauro Perretti Engineering cellular trafficking via glycosyltransferase-programmed stereosubstitution 193 Robert Sackstein The expanding role of 2-3 sialylation for leukocyte trafficking in vivo 201 Markus Sperandio Beyond glycoproteins as galectin counterreceptors: effector T cell growth control of tumors via ganglioside GM1 206 Robert W. Ledeen, Gusheng Wu, Sabine Andre, David Bleich, Guillementte Huet, Herbert Kaltner, Jurgen Kopitz and Hans-Joachim Gabius Online only Polarization of host immune responses by helminth-expressed glycans Donald Harn Jr., Smanla Tundup and Leena Srivastava Carbohydrate-recognition in the immune system: contributions of NGL-based microarrays to ligand discovery Ten Feizi Diversity in recognition of glycans by F-type lectins and galectins: molecular, structural, and biophysical aspects Gerardo R. Vasta, Hafiz Ahmed, Mario A. Bianchet, Jose A. Fernandez-Robledo and L. Mario Amzel


"Glycobiology of the Immune Response explores the integration of state-of-the art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system." ( European Journal of Immunology , 1 December 2012)

EAN: 9781573318396
ISBN: 1573318396
Publisher: New York Academy of Sciences
Dimensions: 25.3 x 17.9 x 0.8 centimetres (0.47 kg)
Age Range: 15+ years
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