An extensive review and reference guide for students and experts alike that encompasses the fundamental biochemical topics related to health and disease
Preface Acknowledgments Introduction 1. Cells: Structure and Functions 2. Water, Acids, Bases, and Buffers 3. Amino Acids 4. Three-Dimensional Structure of Proteins 5. Energetics of Biological Systems 6. Enzymes and Enzyme Regulation 7. Clinical Enzymology and Biomarkers of Tissue Injury 8. Simple Carbohydrates 9. Heteropolysaccharides I: Glycoconjugates, Glycoproteins, and Glycolipids 10. Connective Tissue: Fibrous and Non-Fibrous Proteins and Proteoglycans 11. Gastrointestinal Digestion and Absorption 12. Carbohydrate Metabolism I: Glycolysis and the Tricarboxylic Acid Cycle 13. Electron Transport Chain, Oxidative Phosphorylation, and Other Oxygen-Consuming Systems 14. Carbohydrate Metabolism II: Gluconeogenesis, Glycogen Synthesis and Breakdown, and Alternative Pathways 15. Protein and Amino Acid Metabolism 16. Lipids I: Fatty Acids and Eicosanoids 17. Lipids II: Phospholipids, Glycosphingolipids, and Cholesterol 18. Lipids III: Plasma Lipoproteins 19. Contractile Systems 20. Perturbations of Energy Metabolism: Obesity and Diabetes Mellitus 21. Structure and Properties of DNA 22. DNA Replication, Repair, and Mutagenesis 23. RNA and Protein Synthesis 24. Regulation of Gene Expression 25. Nucleotide Metabolism 26. Hemoglobin 27. Metabolism of Iron and Heme 28. Endocrine Metabolism I: Introduction and Signal Transduction 29. Endocrine Metabolism II: Hypothalamus and Pituitary 30. Endocrine Metabolism III: Adrenal Glands 31. Endocrine Metabolism IV: Thyroid Gland 32. Endocrine Metabolism V: Reproductive System 33. Immunology 34. Biochemistry of Hemostasis 35. Mineral Metabolism 36. Vitamin Metabolism 37. Water, Electrolytes, and Acid-Base Balance 38. Case Studies Appendix
N. V. Bhagavan is an Emeritus Professor in the department of Anatomy, Biochemistry, and Physiology at the John A. Burns School of Medicine, University of Hawaii at Manoa. An active professor, researcher, and teacher, he has many years of experience in both the instruction and practice of clinical biochemistry. Chung-Eun Ha is an Associate Professor in the department of Native Hawaiian Health at the John A. Burns School of Medicine, University of Hawaii at Manoa. Since 2001, he has been teaching medical biochemistry to students who come from disadvantaged backgrounds. He is also actively involved in the various aspects of molecular biology and biochemical research in the field of clinical medicine.
"The contents of the book are quite up to date. The book covers basic, traditional biochemical topics as well as recent developments driven by genomics that caught the interests of everyone, including biochemist and health care personnel and future doctors. Adopting such a concise textbook that covers the many aspects of biochemistry and their relevance to diseases would prepare our pre-med students with a broad understanding of the mechanisms of a large number of health problems. The book would also be a very useful starting point for those who are experts in other fields of basic research but have an interest or need to relate basic biochemical processes to and disease mechanisms in a broad range...This book is very concise on most of the topics it covers. It describes the principles to the point the students need without lengthy elaborations that takes too much time that students often find hard to find due to heavy study load. Accompanied by case studies, this is a very good book for medical orientated students."--Dr. Yuzhu Zhang, Department of Biology, Chemistry, and Physics, Illinios Institute of Technology "The writing style is in general easy to read and the topics that I have reviewed seemed to be explained well."--Dr. William E. Seifert, Department of Biochemistry & Molecular Biology, Purdue University "We adopted the Bhagavan text because it is the most comprehensive and authoritative text on the market and is suitable for our students who have already had at least one semester of biochemistry prior to acceptance in medical school...The chapters on genomics and hematology are handled better by Bhagavan than in other books that I'm familiar with. It was probably this coverage in Bhagavan that made it our choice. The hematology section is better than that in most full hematology books."--Dr. Eugene Allanson, Department of Biochemistry and Molecular Biology, Georgetown University Medical Center