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Essential Haematology


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Table of Contents

Preface to the Sixth Edition vii Preface to the First Edition ix How to get the best out of your textbook x 1 Haemopoiesis 1 2 Erythropoiesis and general aspects of anaemia 15 3 Hypochromic anaemias 33 4 Iron overload 50 5 Megaloblastic anaemias and other macrocytic anaemias 58 6 Haemolytic anaemias 73 7 Genetic disorders of haemoglobin 88 8 The white cells 1: granulocytes, monocytes and their benign disorders 108 9 The white cells 2: lymphocytes and their benign disorders 126 10 The spleen 142 11 The aetiology and genetics of haematological malignancies 150 12 Management of haematological malignancy 166 13 Acute myeloid leukaemia 178 14 Chronic myeloid leukaemia 191 15 The non-leukaemic myeloproliferative neoplasms 200 16 Myelodysplasia 214 17 Acute lymphoblastic leukaemia 223 18 The chronic lymphoid leukaemias 234 19 Hodgkin lymphoma 245 20 Non-Hodgkin lymphoma 253 21 Multiple myeloma and related disorders 272 22 Aplastic anaemia and bone marrow failure 288 23 Stem cell transplantation 297 24 Platelets, blood coagulation and haemostasis 314 25 Bleeding disorders caused by vascular and platelet abnormalities 330 26 Coagulation disorders 345 27 Thrombosis and antithrombotic therapy 362 28 Haematological changes in systemic disease 381 29 Blood transfusion 397 30 Pregnancy and neonatal haematology 413 Appendices 1 Normal values 424 2 World Health Organization classifi cation of tumours of the haematopoietic and lymphoid tissues 426 Index 431

About the Author

Victor Hoffbrand is Emeritus Professor of Haematologyat University College London and Honorary Consultant Haematologistat the Royal Free Hospital, London Paul Moss is Professor of Haematology atthe University of Birmingham, UK


"I recommend this no longer small masterpiece to all who would like to know more about haematology but do not have the good fortune or time to become card-carrying haematologists." ( The Bulletin of The Royal College of Pathologists, 1 January 2012) "This is a great introductory book on clinical hematology. I'd recommend it for anyone early in their medical training or practice, or for any established practitioner wanting a quick refresher course in the subject." (Doody's, 2 September 2011) "Recommended by the British Medical Journal and supported by an online suite of resources, this well-resented full-colour text offers a comprehensive introduction to the creation and functioning of the major blood cells." (Times Higher Education Supplement, 24 February 2011) "Much improved version. I liked the descriptive style where blocks of information gathered on same subject and easy for students to 'connect the dots'." (Athar Aziz, School of Environment & Life Sciences, University of Salford) Reviews of the previous edition: "This is a beautiful book ... packed with superb colour figures, laboratory and clinical illustrations, and is magnificently laid out. The text is clearly written, contains excellent, up-to-date background science, comprehensive clinical and laboratory data and sensible advice on the management of a full range of haematological disorders. My own students were delighted to see a copy and were unanimous in their view that this is a high quality bargain." (Journal of Clinical Pathology) "The molecular and biochemical aspects of modern haematology are simply and clearly explained throughout, so encouraging students to read further from the comprehensive reading list at the end of each chapter... It is a difficult book to fault and must take first place as the undergraduates' handbook for haematology." (British Medical Journal)

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