Fishpond Gift Vouchers - Let them choose!

Shop over a million Toys in our Huge New Range

Enzyme Kinetics in Drug Metabolism

Product Details

Table of Contents

1. Enzyme Kinetics in Drug Metabolism - Fundamentals and Applications Swati Nagar, Upendra A. Argikar, and Donald J. Tweedie Part I. Fundamentals of Enzyme Kinetics 2. Fundaments of Enzyme Kinetics Eleanore Seibert and Timothy S. Tracy 3. Different Enzyme Kinetic Models Eleanore Seibert and Timothy S. Tracy 4. Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance Barbara Ring, Steven A. Wrighton, and Michael Mohutsky 5. Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions Michael Mohutsky and Stephen D. Hall 6. Multi-Enzyme Kinetics and Sequential Metabolism Larry C. Wienkers and Brooke VandenBrink 7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics Nigel J. Waters, R. Scott Obach, and Li Di Part II. Kinetics of Drug Metabolizing Enzymes and Transporters 8. Enzyme Kinetics of Oxidative Metabolism - Cytochromes P450 Ken Korzekwa 9. Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase John T. Barr, Kanika Choughule, and Jeffrey P. Jones 10. Enzyme Kinetics of Conjugative Enzymes - PAPS Margaret O. James 11. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs) Jin Zhou and John Miners 12. Principles and Experimental Considerations for in vitro Transporter Interaction Assays Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Wiskercher, and Ismael J. Hidalgo Part III. Modeling Considerations 13. Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data - from in vitro Tools to Mechanistic Modeling Aleksandra Galetin 14. The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers Joseph Bentz and Harma Ellens 15. Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism Nnena A. Finn and Melissa L. Kemp Part IV. Variability in Kinetics 16. Variability in Human in vitro Enzyme Kinetics Ying-Hong Wang and Christopher R. Gibson 17. Sources of Interindividual Variability Yvonne Lin and Kenneth E. Thummel Part V. Case Studies 18. Case Study 1. Practical Considerations with Experimental Design and Interpretation John T. Barr, Darcy R. Flora, and Otito Iwuchukwu 19. Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies Upendra A. Argikar and Swati Nagar 20. Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies - Real Life Examples Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald J. Tweedie 21. Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast Ken Korzekwa 22. Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development Ian Templeton, Gary Eichenbaum, Rucha Sane, and Jin Zhou 23. Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher, and Ismael J. Hidalgo 24. Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors' Experiences Donald J. Tweedie

Ask a Question About this Product More...
Write your question below:
Look for similar items by category
Home » Books » Science » Medicine » Pharmacology
Home » Books » Science » Biology » Biochemistry
How Fishpond Works
Fishpond works with suppliers all over the world to bring you a huge selection of products, really great prices, and delivery included on over 25 million products that we sell. We do our best every day to make Fishpond an awesome place for customers to shop and get what they want — all at the best prices online.
Webmasters, Bloggers & Website Owners
You can earn a 5% commission by selling Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications (Methods in Molecular Biology) on your website. It's easy to get started - we will give you example code. After you're set-up, your website can earn you money while you work, play or even sleep! You should start right now!
Authors / Publishers
Are you the Author or Publisher of a book? Or the manufacturer of one of the millions of products that we sell. You can improve sales and grow your revenue by submitting additional information on this title. The better the information we have about a product, the more we will sell!
Item ships from and is sold by Fishpond World Ltd.
Back to top