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Section I. SIGNALING 1. Measurement of insulin proteolysis and assessment of insulin-mediated signaling (events) in (liver) endosomes 2. Endosomal sorting and implication for signaling 3. TGF-beta in endosomal signaling 4. Annexin A6 and endosomal signaling 5. PI-3-P in endosomal signaling 6.Endosomal signaling and cell migration 7. Measuring lipid-ginding effectors in endosomal signaling 8. Measuring role for endosomal signaling in tumorigenesis 9. Measurement of endosomal signaling in the immune system 10. Assessment of the TLR3 pathway in endosomal signaling 11. Labeling of platelet-derived growth factor to study its endocytosis and signaling 12. Endosomal signaling and oncogenesis 13. ROS - Containing endosomal compartments: implications for signaling 14. ERBIN in endosomal signaling 15. Lipid raft in endosomal signaling 16. VEGF-A in endosomal signaling 17. Assessment of peptide internalization and endosomal signaling 18. Quantitative proteomic analysis of compartmentalized signaling networks 19. Death signaling endosomes: sequential activation of Caspase-8, Caspase-9, acid sphingomyelinase and Cathepsin D in internalized TNF-receptosomes 20. Deubiquitinases and their emerging roles in cell signaling 21. NF-kB-dependent pathway in human keratinocytes 22. Endosomal signaling by the G protein coupled PARs 23. Investigating signaling consequences of GPCR trafficking in the endocytic pathway 24. MICAL-L1 in endosomal signaling
P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science.