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Drug Discovery and Development


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Contents SECTION 1 INTRODUCTION AND BACKGROUND 1. The development of the pharmaceutical industry H P Rang 2. The nature of disease and the purpose of therapy H P Rang, R G Hill 3. Therapeutic modalities H P Rang, H LeVine, R G Hill SECTION 2 DRUG DISCOVERY 4. The drug discovery process: general principles and some case histories H P Rang, R G Hill 5. Choosing the project H P Rang, R G Hill 6. Choosing the target H P Rang, R G Hill 7. The role of information, bioinformatics and genomics B Robson, R McBurney 8. High-throughput screening D Cronk 9. The role of medicinal chemistry in the drug discovery process P Beswick, A Naylor 10. DMPK optimization strategy in drug discovery P G Ballard, P Brassil, K H Bui, H Dolgos, C Petersson, A Tunek, P J H Webborn 11. Pharmacology: its role in drug discovery H P Rang 12. Biopharmaceuticals H LeVine 13. Scaffolds: Small globular proteins as antibody substitutes D Grabulovski, J Bertschinger SECTION 3 DRUG DEVELOPMENT 14. Drug development: introduction H P Rang, R G Hill 15. Assessing drug safety H P Rang, R G Hill 16. Pharmaceutical developmentT Lundqvist, S Bredenberg 17. Clinical Development - Present and Future C Keywood 18. Clinical imaging in drug development P M Matthews 19. Intellectual property in drug discovery and development P Grubb 20. Regulatory affairs I H ggl f, Holmgren 21. Marketing the drug V L Lawton SECTION 4 FACTS AND FIGURES 22. Drug discovery and development - facts and figures H P Rang, R G Hill

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