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The full range of scientific and clinical perspectives on Cryptococcus at your fingertips. Covers both the Cryptococcus neoformans and Cryptococcus gattii species, examining in detail the life cycle, pathophysiology, molecular biology, genetics, genomics, epidemiology, immunology, and clinical management of this encapsulated yeast. Provides in-depth discussions of the 1999 Vancouver Island C. gattii outbreak that spread to the Canadian mainland and the United States, causing infections in both humans and animals. Discusses diagnosis, treatment, prevention, and other clinical perspectives on Cryptococcus infection Serves as a resource for molecular biologists, microbiologists, public health officials, epidemiologists, and infectious disease clinicians. This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.
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Table of Contents

Table of Contents I. GENERAL PRINCIPLES 1. Systematics of the Genus Cryptococcus and Its Type Species C. neoformans, Kyung J. Kwon-Chung, Teun Boekhout, Brian L. Wickes, and Jack W. Fell 2. The History of Cryptococcus and Cryptococcosis, John R. Perfect and Arturo Casadevall 3. Biosynthesis and Genetics of the Cryptococcus Capsule, Guilhem Janbon and Tamara L. Doering 4. The Architecture and Antigenic Composition of the Polysaccharide Capsule, Marcio L. Rodrigues, Arturo Casadevall, and Oscar Zaragoza 5. Melanin: Structure, Function, and Biosynthesis in Cryptococcus, David Trofa, Arturo Casadevall, and Joshua D. Nosanchuk 6. The Cell Wall of Cryptococcus, Nicole M. Gilbert, Jennifer K. Lodge, and Charles A. Specht 7. Sexual Reproduction of Cryptococcus, Yen-Ping Hsueh, Xiaorong Lin, Kyung J. Kwon-Chung, and Joseph Heitman 8. Population Structure and Ecology of Cryptococcus neoformans and C. gattii, Anastasia P. Litvintseva, Jianping Xu, and Thomas G. Mitchell II. GENETICS AND GENOMICS 9. The Cryptococcus Genomes: Tools for Comparative Genomics and Expression Analysis, James W. Kronstad, Brendan J. Loftus, and Jennifer K. Lodge 10. Genetic and Genomic Approaches to Cryptococcus Environmental and Host Responses, Alexander Idnurm and Peter R. Williamson 11. The Mating Type Locus of Cryptococcus: Evolution of Gene Clusters Governing Sex Determination and Sexual Reproduction, from the Phylogenomic Perspective, Yen-Ping Hsueh, Banu Metin, Keisha Findley, Marianela Rodriguez-Carres, and Joseph Heitman III. SIGNALING AND VIRULENCE 12. G-Protein Signaling Pathways Regulating Morphogenesis and Virulence of Cryptococcus, J. Andrew Alspaugh, Connie B. Nichols, Chaoyang Xue, Wei-Chiang Shen, and Ping Wang 13. A Role for Mating in Cryptococcal Virulence, Kirsten Nielsen and Kyung J. Kwon-Chung 14. Sensing Extracellular Signals in Cryptococcus neoformans, Alexander Idnurm, Yong-Sun Bahn, Wei-Chiang Shen, Julian C. Rutherford, and Fritz A. Muhlschlegel 15. Virulence Mechanisms of Cryptococcus gattii: Convergence and Divergence, Sudha Chaturvedi and Vishnu Chaturvedi 16. Drug Resistance in Cryptococcus: Epidemiology and Molecular Mechanisms, Michael A. Pfaller, Jennifer K. Lodge, and M. A. Ghannoum 17. Signaling Cascades and Enzymes as Cryptococcus Virulence Factors, Deborah S. Fox, Julianne Djordjevic, and Tania C. Sorrell IV. ENVIRONMENTAL INTERACTIONS AND POPULATION GENETICS 18. Environmental Niches for Cryptococcus, Thomas G. Mitchell, Elizabeth Castaneda, Kirsten Nielsen, Bodo Wanke, and Marcia S. Lazera 19. Cryptococcus neoformans: Nonvertebrate Hosts and the Emergence of Virulence, Jeffrey J. Coleman, Cara J. Chrisman, Arturo Casadevall, and Eleftherios Mylonakis 20. Cryptococcosis in Africa, Nelesh Govender, Thomas G. Mitchell, Anastasia P. Litvintseva, and Kathleen J. Miglia 21. Cryptococcosis in Asia, Jiangping Xu, Weerawat Manosuthi, Uma Banerjee, Li-Ping Zhu, Janghan Chen, Shigeru Kohno, Koichi Izumikawa, Yuchong Chen, Somnuek Sungkanuparph, Thomas S. Harrison, and Matthew Fisher 22. Sexual Reproduction of Cryptococcus gattii: a Population Genetics Perspective, Dee Carter, Leona Campbell, Nathan Saul, and Mark Krockenberger 23. The Emergence of Cryptococcus gattii Infections on Vancouver Island and Expansion in the Pacific Northwest, Karen Bartlett, Edmond Byrnes, Colleen Duncan, Murray Fyfe, Eleni Galanis, Joseph Heitman, Linda Hoang, Sarah Kidd, Laura MacDougall, Sunny Mak, Kieren Marr, Muhammad Morshed, Sarah Klizas West, and James Kronstad 24. Molecular Typing of the Cryptococcus neoformans/C. gattii Species Complex, Wieland Meyer, Felix Gilgado, Popchai Ngamskulrungroj, Luciana Trilles, Ferry Hagen, Elizabeth Castaneda, and Teun Boekhout 25. Hybridization and Its Importance in the Cryptococcus Species Complex, Massimo Cogliati, Xiaorong Lin, and Maria Anna Viviani V. INTERACTIONS WITH THE IMMUNE SYSTEM 26. The Interaction of Cryptococcus neoformans with Host Macrophages and Neutrophils, Travis McQuiston and Maurizio Del Poeta 27. T-Cell and Dendritic-Cell Immune Responses to Cryptococcus, Karen L. Wozniak and Stuart M. Levitz 28. Acquired Humoral Immunity to Cryptococcus neoformans, Liise-anne Pirofski and Arturo Casadevall 29. Interactions of Capsule with Antibody and Complement, Thomas R. Kozel 30. Cryptococcus Interactions with Innate Cytotoxic Lymphocytes, Shaunna M. Huston and Christopher H. Mody VI. PATHOGENESIS OF CRYPTOCOCCUS 31. Cryptococcus neoformans: Latency and Disease, Francoise Dromer, Arturo Casadevall, John Perfect, and Tania Sorrell 32. Intracellular Replication and Exit Strategies, Kerstin Voelz, Simon A. Johnston, and Robin C. May 33. Pulmonary Innate and Adaptive Defenses against Cryptococcus, Kristi L. Williams, Floyd L. Wormley, Jr., Scarlett Geunes-Boyer, Jo Rae Wright, and Gary B. Huffnagle 34. Invasion of Cryptococcus into the Central Nervous System, Francoise Dromer and Stuart M. Levitz 35. Cryptococcosis in Experimental Animals: Lessons Learned, Karl V. Clemons and David A. Stevens 36. Veterinary Insights into Cryptococcosis Caused by Cryptococcus neoformans and Cryptococcus gattii, Richard Malik, Mark B. Krockenberger, Carolyn R. O'Brien, Dee A. Carter, and Wieland Meyer VII. DIAGNOSIS, TREATMENT, PREVENTION, AND CLINICAL PERSPECTIVES 37. Cryptococcosis in Transplant Recipients, Nina Singh and Barbara D. Alexander 38. Cryptococcosis in AIDS, Bettina C. Fries and Gary M. Cox 39. Antifungal Trials: Progress, Approaches, New Targets, and Perspectives in Cryptococcosis, Peter G. Pappas 40. Vaccines and Antibody Therapies from Cryptococcus neoformans to Melanoma, Arturo Casadevall, Ekaterina Dadachova, and Liise-anne Pirofski 41. Diagnostic Approach Based on Capsular Antigen, Capsule Detection, ss-Glucan, and DNA, Mara R. Diaz and M. Hong Nguyen 42. Management of Cryptococcal Meningoencephalitis in Both Developed and Developing Countries, Joseph N. Jarvis, Tihana Bicanic, and Thomas S. Harrison 43. Public Health Importance of Cryptococcal Disease: Epidemiology, Burden, and Control, Benjamin J. Park, Shawn R. Lockhart, Mary E. Brandt, and Tom M. Chiller 44. Clinical Perspectives on Cryptococcus neoformans and Cryptococcus gattii: Implications for Diagnosis and Management, Tania C. Sorrell, Sharon C.-A. Chen, Peter Phillips, and Kieren A. Marr

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