Table of Contents

1 Carbon Monoxide and Human Functions.- Background.- Recent Work in our Laboratory.- Discussion.- Summary.- Acknowledgments.- References.- General Discussion.- 2 The Effect of Carbon Monoxide on Time Perception, Manual Coordination, Inspection, and Arithmetic.- Experimental Method.- Results.- Discussion.- Summary.- References.- General Discussion.- 3 Preliminary Studies of the Effects of Carbon Monoxide on Vigilance in Man.- Method.- Results.- Discussion.- Summary.- References.- General Discussion.- 4 Carbon Monoxide and Human Performance: A Methodological Exploration.- Method.- Experiment I. Simultaneous Digit-Processing and Peripheral Detection.- Experiment II. The Rate Threshold of Blocking.- Experiment III. Simultaneous Digit-Processing and Double-Jump Detection.- Experiment IV. Effects of Carbon Monoxide on Eye Movements and Monitoring Performance.- Experiment V. Effects of Carbon Monoxide on Self-Paced Digit Keying.- Concluding Remarks.- Summary.- Acknowledgments.- References.- General Discussion.- 5 The Comparative Effects of Hypoxic and Carbon Monoxide Hypoxia on Behavior.- Procedures.- Hypoxia.- Carbon Monoxide.- References.- General Discussion.- 6 The Application of a Computer-Controlled Time Discrimination Performance to Problems in Behavioral Toxicology.- Methods and Materials.- Time Discrimination Thresholds.- Effects of Chorpromazine on Time Discrimination.- Effects of Carbon Monoxide on Time Discrimination.- Summary.- Acknowledgments.- References.- General Discussion.- 7 Behavioral Toxicity of Anticholinesterase Agents: Methodological, Neurochemical, and Neuropsychological Aspects.- Materials and Methods.- Acute Anticholinesterase Effects.- Subacute and Chronic Anticholinesterase Effects.- Possible Central Actions of Enzyme Reactivations.- Cholinergic Systems and Behavior.- Human Anticholinesterase Intoxication.- General Discussion and Conclusions.- Summary.- Acknowledgments.- References.- General Discussion.- 8 Behavioral Toxicologic Studies of Dieldrin, DDT, and Ruelene in Sheep.- Method.- Results.- Discussion.- Summary.- Acknowledgments.- References.- General Discussion.- 9 Use of Behavioral Techniques in the Assessment of Environmental Contaminants.- Pertinent Literature.- Lashley III Maze.- Fixed Interval Operant Conditioning.- DRL Operant Conditioning.- Behavioral Research Interface.- References.- General Discussion.- 10 Utilities and Limitations of Behavioral Techniques in Industrial Toxicology.- The Determination of Behavioral Performance Decrement during Inhalation Exposure to Halogenated Solvents.- The Complementarity of Behavioral and Pathological Methodology in the Toxicology of a New Compound.- The Problems and Significance of Individual Differences in Behavioral Toxicology.- Conclusions.- Technical Appendix.- References.- General Discussion.- 11 Effects of the Inhalation of Cigarette Smoke on Swimming Endurance and Avoidance Behavior in the Rat.- The Inhalation Technique.- The Effects on Swimming Endurance.- Effects on Avoidance Behavior Under Extinction Procedure.- Discussion.- Summary.- References.- General Discussion.- 12 Behavioral Teratology and Toxicology.- Basic Considerations in Behavioral Teratology.- Subtle and Long-Term Consequences of Prenatal Exposure to Methylmercury.- Summary.- References.- General Discussion.- 13 Effects of Drugs on Schedule-Controlled Behavior and Cardiovascular Function in the Squirrel Monkey.- Effects of Drugs on Schedule-Controlled Behavior.- Cardiovascular Changes Associated with Schedule-Controlled Behavior.- Measurements of Blood Pressure and Heart Rate.- Changes inBlood Pressure and Heart Rate Under Fixed-Ratio Schedules.- Effects of Drugs on Cardiovascular Function during Behavioral Experiments.- Acknowledgment.- References.- General Discussion.- 14 Behavioral, Biochemical, and Morphological Effects of Methamphetamine in the Rhesus Monkey.- General Methodology.- The Acute Lethal Dose of Intravenous Methamphetamine.- Acute Effects of Methamphetamine on Food- and Water-Reinforced Fixed-Ratio Behavior.- Chronic Effects of Methamphetamine on Food-Reinforced Fixed-Ratio Behavior.- The Effects of Methamphetamine on DRL Performance.- Biochemical and Morphological Effects of Chronic Methamphetamine.- Conclusions.- References.- General Discussion.- 15 Behavioral Assessment of Ototoxicity in Nonhuman Primates.- Method.- Results.- Summary.- Acknowledgment.- References.- General Discussion.- 16 Quantitative Perspectives on the Long-Term Toxicity of Methylmercury and Similar Poisons.- 17 An Overview of Behavioral Toxicology.- Author Index.

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