Table of Contents

Introduction to Antimicrobial Therapeutics Reviews: The bacterial cell wall as an antimicrobial target v
Karen Bush

Recent trends in resistance to cell envelope ? active antibacterial agents among key bacterial pathogens 1
Ronald N. master, Jennifer Deane, Carol Opiela and Daniel F. Sahm

The physiology of bacterial cell division 8
Alexander J. F. Egan and Waldemar Vollner

Viable screening targets related to the bacterial cell wall 29
Lynn L. Silver

Bacterial cell-wall recycling 54
Jarrod W. Johnson, Jed F. Fisher and Shahriar Mobashery

?-Lactam antimicrobials: what have you done for me lately? 76
George H. Talbot

Proliferation and significance of clinically relevant ?-lactamases 84
Karen Bush

Metallo-?-lactamase structure and function 91
Timothy Palzkill

New?-lactam-?-lactamase inhibitor combinations in clinical development 105
David M. Shlaes

Siderophore conjugates 115
Malcolm G. P. Page

Peptide antimicrobials: cell wall as a bacterial target 127
Nannette Y. Yount and Michael R. Yeaman

Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall 139
Arnold S. Bayer, Tanja Schneider and Hans-Georg Sahl

Errata for Ann. N. Y. Acad. Sci. Volumes 1274 and 1275 159