Part I. Pain Physiology and Pharmacology: 1. Pain pathways and acute pain processing; 2. The pathophysiology of acute pain; 3. Patient variables influencing acute pain management; 4. Acute pain: a psychosocial perspective; 5. Non-steroidal anti-inflammatory drugs and acetaminophen: pharmacology for the future; 6. Local anesthetics in regional anesthesia and acute pain management; 7. Pharmacology of novel non-NSAID analgesics (Ketamine, Clonidine, Gabapentin); 8. Pharmacokinetics of epidural opioids; 9. Transitions from acute to chronic pain; 10. Molecular basis and clinical implications of opioid tolerance and opioid-induced hyperalgesia; Part II. Clinical Analgesia: 11. Qualitative and quantitative assessment of pain; 12. The role of preventive analgesia and impact on patient outcome; 13. Opioid oral and parenteral opioid analgesics for acute pain management; 14. IV-PCA (history, technical aspects, agents, dosing, risk vs. benefits, effects on pain, satisfaction, effect on outcome); 15. Clinical application of epidural analgesia; 16. Neuraxial analgesia with hydromorphone morphine and fentanyl: dosing and safety guidelines; 17. Regional anesthesia for acute pain in the in-patient setting; 18. Regional anesthesia for acute pain management in the outpatient setting; 19. Patient controlled analgesia devices and analgesic infusion pumps; 20. Novel analgesic drug delivery systems for acute pain management; 21. Non-selective non-steroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase-2 inhibitors (COX-2Is), and acetaminophen in acute perioperative pain; 22. Perioperative ketamine for better postoperative pain outcome; 23. Clinical application of glucocorticoids, anti-neuropathics and other analgesic adjuvants for acute pain management; 24. Non-pharmacological approaches for acute pain management; 25. Adverse events associated with opioid therapy and their treatment (incidence of adversity, nausea, vomiting respiratory depression, ileus, etc.); 26. Respiratory depression: incidence, diagnosis, and treatment; Part III. Acute Pain Management in Special Patient Populations: 27. Acute pain management services: organization and implementation issues; 28. Acute pain management in the community hospital setting; 29. Ambulatory surgical pain: economic aspects and optimal analgesic management; 30. Pediatric acute pain management (oral, parenteral, neuraxial); 31. Acute pain management for elderly 'high risk' and cognitively impaired patients: rationale for regional analgesia; 32. Post-cesarean analgesia; 33. Acute pain management in Sickle Cell Disease patients; 34. Acute pain management in patients with opioid dependency and substance abuse (including buprenorphine); Part IV. Specialist Managed Pain: 35. Pain management following colectomy: a surgeon's perspective (balancing analgesia vs. side effects); 36. Acute pain management in the emergency department (medical and trauma related pain); 37. The nurse's role in acute pain management; 38. The role of the pharmacist in acute pain management; Part V. Pain Management and Patient Outcomes: 39. Economics and costs: a primer for acute pain management specialists; 40. Evidence based medicine (does optimal analgesia improve outcome/satisfaction in post-surgical settings); 41. Effect of epidural analgesia on postoperative outcomes; 42. Research in acute pain management; 43. Quality improvement approaches in acute pain management; 44. The future of acute pain management (where we are heading?).
This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Dr. Raymond Sinatra is Professor of Anesthesiology at the Yale University School of Medicine. Dr Oscar A. de Leon-Casasola is Professor of Anesthesiology and Chief of Pain Medicine in the Department of Anesthesiology of the Roswell Park Cancer Institute. His research interests include advances in analgesic therapy, physiology and pharmacology of epidural opioids, perioperative surgical outcomes, thoracic and cardiac anesthesia, acute pain control, and chronic cancer pain. He is a member of the American Society of Regional Anesthesia, American Society of Anesthesiologists, New York State Society of Anesthesiologists, American Pain Society, and Eastern Pain Association. Dr de Leon-Casasola has authored or co-authored 115 journal articles, abstracts, and book chapters. He serves as an associate editor for the Latin American Journal of Pain, the Argentinian Journal of Anesthesiology, the Journal of the Spanish Society of Pain, and the Clinical Journal of Pain. He also is editor-in-chief of Techniques in Regional Anesthesia and Pain Management and was listed as an exceptional practitioner by Good Housekeeping Magazine in 2003. Dr Brian Ginsberg is Professor of Anesthesiology and Medical Director in the Division of Acute Pain Therapy in the Department of Anesthesiology of Duke University School of Medicine. Dr Eugene Viscusi is Assistant Professor of Anesthesiology and the Director of Regional Anesthesia and Acute Pain Management in the Department of Anesthesiology at Thomas Jefferson University.
'... an excellent book, all the major, and a good deal of the lesser subjects are covered in suitable detail, and the book could easily become a point of reference in any Acute Pain Service.' British Journal of Anaesthesia