Table of Contents

The Life of Doctor Pierre Marie: A Great Granddaughter–s View.- I. Molecular Biology and Physiology of GH Action.- 1. Etiology of Acromegaly from the Neuroendocrine Point of View: A Historical Perspective.- 2. Human Growth Hormone Gene Regulation in Somatotroph Cell Cultures.- 3. Detection of the Multiple Forms of Human Growth Hormone.- 4. Molecular Heterogeneity of Circulating Growth Hormone in Acromegaly.- 5. Somatomedin Gene Expression.- 6. Somatomedin Action and Tissue Growth Factor Receptors.- 7. The Mechanism of the Growth-Promoting Action of Growth Hormone.- II. Regulation of Growth Hormone Secretion.- 8. Somatostatin and the Syndrome of Acromegaly.- 9. Growth Hormone Secretion in Acromegaly.- 10. Actions of GRF in Man.- 11. GRF Secretion in Man.- 12. Ectopic GRH Syndromes.- III. Diagnosis of Acromegaly.- 13. Clinical Developments Over the Past 100 Years of Acromegaly.- 14. Gonadal Steroid Modulation of Growth Hormone Secretory Patterns in the Rat.- 15. Pathogenesis of Acromegaly.- 16. Pathology of Acromegaly.- 17. Associated Hypersecretion of Anterior Pituitary Hormones Other Than Growth Hormone in Acromegaly.- 18. Effect of Growth Hormone on Carbohydrate and Lipid Metabolism: An Overview.- 19. The Diagnosis of Acromegaly.- IV. Treatments for Acromegaly.- 20. Conventional Supervoltage Radiation in the Treatment of Acromegaly.- 21. Long-Term Effects of Proton Beam Therapy for Acromegaly.- 22. Results of Transsphenoidal Resection of Growth Hormone-Secreting Pituitary Adenomas.- 23. Long-Term Results of Transsphenoidal Surgery for the Management of Acromegaly.- 24. The Use of Somatostatin Analogs in the Treatment of Acromegaly.- 25. The Use of Dopamine Agonists in the Management of Acromegaly.- 26. Decision Analysis of Treatment Options in Acromegaly.- Author Index.