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Table of Contents

Contributors vii Preface ix 1 Development of the Epidemic 1 B. Sultan and M. W. Adler 2 Immunology of HIV-1 Infection 6 M. Noursadeghi and D. Pillay 3 Viral Assays Used in the Diagnosis and Management of HIV Infection 10 A. M. Geretti and P. Vitiello 4 HIV Testing: Strategies to Prevent Late Diagnosis 15 A. Palfreeman and E. Fox 5 Clinical Staging and Natural History of Untreated HIV Infection 20 M. Tenant-Flowers and A. Mindel 6 Routine Assessment and Follow-up of the Newly Diagnosed HIV-positive Individual 25 L. Waters and D. Asboe 7 Tumours in HIV 29 M. Bower 8 The Lung and HIV 35 S. Doffman and R. F. Miller 9 HIV and Tuberculosis Co-infection 42 F. Perrin, R. Breen and M. Lipman 10 The Gut and HIV 48 B. Gazzard and M. Nelson 11 Viral Hepatitis and Liver Disease 54 R. Gilson and H. Price 12 Neurological Manifestations 59 H. Manji and R. F. Miller 13 The Eye and HIV 67 C. Younan W. Lynn and S. Lightman 14 The Skin and HIV 72 R. Morris-Jones and E. Higgins 15 The Kidney and HIV 78 J. Booth and J. Connolly 16 Sexually Transmitted Infections and HIV 83 P. French 17 Women and HIV 87 C. Wilkinson and D. Mercey 18 HIV Infection in Children 91 P. McMaster and S. Stokes 19 Antiretroviral Drugs 97 P. Benn, G. Sethi and I. G. Williams 20 Pharmacopoeia of Treatments 101 J. Minton, G. Sethi and S. G. Edwards 21 Psychological and Mental Health Issues 108 B. Hedge 22 Strategies for Preventing HIV Transmission 114 J. Imrie and G. J. Hart 23 Patient and Community Perspective 120 G. Brough and N. Lubega 24 The Role of Patient Engagement 123 C. Sandford Index 127

About the Author

Edited by Michael W. Adler, Professor of GenitourinaryMedicine/Sexually Transmitted Diseases, Royal Free and UniversityCollege Medical School, London, UK Simon G. Edwards, GU/HIV Clinician, Mortimer MarketCentre, London, UK Robert F. Miller, Reader in Clinical Infection andHonorary Consultant Physician, Royal Free and University CollegeMedical School, London, UK Gulshan Sethi, Department of Sexual Health, StThomas Hospital, London, UK Ian G. Williams, Senior Lecturer and Honorary ConsultantPhysician, Royal Free and University College Medical School,London, UK


An authoritative guide to the epidemiology, incidence,testing and diagnosis and management of HIV andAIDS. (MedReview, 1 November 2012) This excellent new edition has been updated to incorporatedevelopments and current issues in the management of HIV This edition is highly recommended as the best available overviewon HIV and AIDS (acquired immunodeficiency syndrome). ( British Journal of Hospital Medicine, 1 August 2012)

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