Thirty something Annie (Kristin Wiig) has hit a rough patch but her life turned completely upside down when she takes on the Maid of Honour role in her best friend Lillian's (Maya Rudolph) wedding. In way over her head but determined to succeed, Annie leads a hilarious ensemble of bridesmaids (Rose Byrne, Melissa McCarth, Wendi McLendon-Covey and Elle Kemper) on a wild ride down to the big event.