Dead Space Extraction tells the story of a handful of space colonists desperately struggling to escape from a horrific infection on the Aegis VII mining colony deep in the furthest regions of space. The game introduces a new heroine to the fiction and as the crew fall victim to a mysterious contagion aboard the ship, it becomes clear that protecting her may be their only hope for survival. Dead Space Extraction introduces all new characters, weapons, enemies, puzzles and co-operative multiplayer gameplay.

Built from the ground up and developed exclusively for the Wii, Dead Space Extraction is a prequel that reveals the events leading up to Isaac Clarke's mission on the USG Ishimura in the original Dead Space game released in 2008. Dead Space Extraction marries the innovative motion controls of the Wii Remote with a frenetic first person perspective to create a new action-packed horror experience.