SECTION I: MOUTH AND ESOPHAGUS
Anatomy, Embryology, and Congenital Anomalies of the Mouth and Esophagus: Jonathan E. Teitelbaum
Disorders of the Oral Cavity: Stephen R. Porter, Paul Ashley
Disorders of Deglutition: David N. Tuchman
Esophageal Motility
Normal Motility and Development of the Esophageal Neuroenteric System: Salvatore Cucchiara, Giovanni Di Nardo, and Salvatore Oliva
Gastroesophageal Reflux: Collin Rudolph, Eric Hassall
Other Esophageal Neuromuscular Disorders: Benjamin D. Gold
Esophagitis: Mike Thomson
Toxic and Traumatic Injury of the Esophagus: Emmanuel Mas, Anne Breton, Jean-Pierre Olives
SECTION II: THE STOMACH AND DUODENUM
Anatomy, Embryology, and Congenital Anomalies: Sanne Rosekrans, Nikè V.J.A. Büller, Nikhil Thapar, Gijs R. van den Brink
Nausea and Vomiting (including Pyloric Stenosis): B. Li, Katja Kovacic
Gastritis: Helicobacter pylori and Peptic Ulcer Disease: Marion Rowland, Billy Bourke, Brendan Drumm
Acid-Peptic Disease: Frédéric Gottrand
Other Causes of Gastritis: C. Y. Ooi, D. A. Lemberg, Andrew S. Day
Esophageal and Gastric Neoplasms: Robert Riddell, David Schaeffer
Development of the Gastric Neuroenteric System
Normal Motility and Development of the Gastric Neuroenteric System: Miguel Saps, Carlo Di Lorenzo
Motility Disorders: Miguel Saps, Carlo Di Lorenzo
SECTION III: THE INTESTINE
Anatomy and Embryology: Pascal De Santa Barbara
Congenital Anomalies Including Hernias: David Lloyd, Simon Edward Kenny, David Wilkinson
Lymphatic Disorders: Pierre Yves Vonder Weid, Decker Butzner
Absorption and Digestion
Normal Physiology: Jean Pierre Cézard
Acute Diarrhea: Stephano Guandalini
Persistent and Chronic Diarrhea: Alfredo Guarino, Roberto Berni Cancani
Genetically Determined Disaccharidase Deficiency: Hassan Y. Naim, Mahdi Amiri, Klaus-Peter Zimmer
Congenital Intestinal Transport Defects: Martin G. Martin, Ernest M. Wright
Congenital Enteropathies: Olivier Goulet, Julie Salomon
Immune Enteropathies
Celiac Disease: Alessio Fasano
Eosinophilic Esophagitis: Clies Menard-Katcher, Chris Liacouras, Vincent Mukkada, Glenn Furuta, Marc Rothenberg
Allergic Enteropathy: Franco Torrente, Simon Murch
Autoimmune Enteropathy and IPEX Syndrome: Frank M. Ruemmele, Nicole Brousse, Olivier Goulet
Surgical Disorders
Intestinal Obstructions: Brad Warner, Elizabeth Fialkowski
Appendicitis: Kevin N. Johnson, Craig Egan, Dennis P. Lund
The Pediatric Ostomy: Catherine Cord-Udy
Perianal Lesions: Sidney Johnson, Tom Jaksic
Microbial Interactions with Gut Epithelium: Nicola L. Jones, Eytan Wine, Seamus Hussey
Modulation of the Intestinal Flora
Probiotics: David Mack
Prebiotics, Symbiotics, and Fermented Products: Glenn Gibson
Antimicrobials: Michael R. Millar, Mark Wilks
Infections
Bacterial Infections, Food and Waterborne Infections: Mitchell Cohen
Viral Infections: Dorsey M. Bass
Parasitic and Fungal Infections: Michael Farthing, Paul Kelly, Beatrice Amudi
Immune and Inflammatory Disorders
Immunology Adaptive and Innate: James Chen
Immunodeficiency and the Intestine, Including GI Manifestations of Primary Immunodeficiency Diseases: Delane Shingadia, Amel Hassan
Necrotizing Enterocolitis: Erika C. Claud, Michael Caplan
Cronic Inflammatory Bowel Disease
Crohn's Disease: Anne M. Griffiths, Jean-Pierre Hugot
Ulcerative and Indeterminate Colitis: Nick Croft
Atypical Colitis and Other Inflammatory Disease: Barbara A. Kirschner, Ranjana Gokhale
Surgical Aspects: Jacob C. Langer
Peritonitis: Ori Rotstein, David Hackam
Intestinal Failure
Short Bowel Syndrome: Yigal Finkel, John Puntis
Intestinal Failure: Associated Liver Disease: Julie E. Bines, Prue Pereira-Fantini
Small Intestinal Transplantation: Stuart S. Kaufman
Intestinal Tumors
Intestinal Polyps and Polyposis: Jean-François Mougenot, Sylviane Olschwang, Michel Peuchmaur
Other Neoplasms: Kamran Badizadegan, Rhea J. Birusingh
Intestinal Motility
Normal Motility and Development of the Intestinal Neuroenteric System: Annamaria Staiano, Massimo Martinelli
Motility Disorders
Idiopathic Constipation: Aliye Uc, Riad Rahhal
Hirschsprung Disease: Cheryl Gaiepy, Steven L. Ciciora
Other Dysmotilities Including Chronic Intestinal Pseudo-obstruction Syndrome: Jaime Belkind-Gerson
IBS Including Colic, Gas, and Abdominal Pain: Mark Benninga
Gastrointestinal Aspects of Systemic Endocrinopathies: Yaron Avitzur, Karolina Burkhardt
Bowel Injury
Drug-Induced Bowel Injury: Shinya Ito
Radiation-Induced Bowel Injury: Agnes François
SECTION IV. THE LIVER
Anatomy and Embryology: Mark Davenport
Physiology
Bile Formation and Cholestasis: Saul Karpen
Bilirubin Metabolism: Glenn R. Gourley
Fibrogenesis and Cirrhosis: Ross W. Shepherd
Normal Hepatocyte Function and Mechanisms of Dysfunction: Ira Fox
Diagnostic Approaches to Common Pediatric Liver Problems: Etienne Sokal
Disorders of the Biliary Tract
Disorders of the Intrahepatic Ducts: Ekkhard Sturm
Biliary Atresia: Kathleen M. Campbell, Jorge A Bezerra
Sclerosing Cholangitis: Dennis Black
Choledocal Cysts and Other Biliary Disorders: Philip Rosenthal
Infections Viral Infections
Hepatitis B Virus: Mei-Wei Chang
Hepatitis C Virus: Daniel Leung
Other Viral Infections: Jaime Chu, Ronen Arnon
Bacterial, Parasitic, and Other Infections: Dinesh Pashankar, Richard A. Shreiber
Immune Deficiency and the Liver: Collin Ball, Dino Hadzic
Autoimmune Disease: Diego Vergani, Marianne Samyn
Drug-Induced Hepatotoxicity: Eve A. Roberts
Liver Tumors: Milton Finegold, Joel E. Haas
Genetic and Metabolic Disorders
Genetic Testing in Clinical Practice: Nancy Spinner
Carbohydrate Metabolism: Simon Horslen
Amino Acid Metabolism: Karen F. Murray, Amy C. Tsai
Disorders of Mitochondrial and Fatty Acid Metabolism: Roshni Vara
?1-Antitrypsin Deficiency: David H. Perlmutter
Zelleweger Syndrome and Other Disorders of Proximal Metabolism: Steven Steinberg, Gerald V. Raymond, Paul A. Watkins
Lysosomal Acid Lypase Deficiencies: Wolman Disease and Cholestyrl Ester Storage
Disease: Gregory A. Grebowski, Kevin Bove, Hong Du
Wilson Disease: Stuart Tanner
Iron Storage Diseases: Peter Whitington, Paul Adams
Biliary Transport: Laura Bull, Lee Bass
Bile Acid Synthesis Disorders: Ken Setchell, James Heubi
Fatty Liver Disease: Valerio Nobili
Systemic Conditions Affecting the Liver: Samar Ibrahim, Deborah Freese, Mounif El-Youssef
Acute Liver Failure: Sanjay Bansal, Anil Dhawan
Treatement of End-Stage Liver Disease: Suzanne McDiarmid
Liver Transplantation: Hector Vilca-Melendez
Gallbladder Disease: Annemarie Broderick, Brian T. Sweeney
SECTION V: THE PANCREAS
Congenital Anomalies, Including Embryology, Anatomy, and Physiology: Dominique M. Jan
Tumors: Michael Hii, Assad M. Butt
Pancreatitis
Acute and Chronic Pancreatitis: David C. Whitcomb, Mark E. Lowe
Juvenile Tropical Pancreatitis: S. Pitchumoni, Viswanathan Mohan
Exocrine Pancreatic Dysfunction
Cystic Fibrosis: Michael Wilschanski
Shwachman-Diamond Syndrome: Peter R. Durie
Other Hereditary and Acquired Pancreatic Disorders: Michael Wilschanski
SECTION VI: DIAGNOSIS OF GASTROINTESTINAL DISORDERS
Gastrointestinal Endoscopy
Patient Preparation and General Considerations: Victor L. Fox
Upper Gastrointestinal Endoscopy: Simon Murch
Upper Gastrointestinal Bleeding: Mark A. Gilger, K. Lynette Whitfield Van Buren
Ileocolonoscopy and Enteroscopy: Mike Thomson
Lower Gastrointestinal Bleeding: Dominique Turck, Laurent Michaud
Gastrointestinal Endosonography: Victor L. Fox
Endoscopic Retrograde Cholangiopancreatography: Claude Liguory, François Mougenot, Andrade de Paulo
Interventional Endoscopy: Recent Innovations: Mike Thomson
Liver Biopsy Interpretation: A.S. Knisely
Intestinal Biopsy: Alan David Phillips, Virpi V. Smith
Gastrointestinal Manometry: Methodology and Indications: Samuel Nurko
Esophageal pH and Impedance Measurement: Yvan Vandenplas, Silvia Salvatore
Imaging
Imaging of Gastrointestinal Tract Disease: Debra Gervais, Michael Gee
Cross-Sectional Imaging: Ultrasonography, Computed Tomography, Magnetic Resonance Imaging---Including Abdominal Masses and MRCP: Debra Gervais, Michael Gee
Interventional Gastrointestinal Radiography: Debra Gervais, Michael Gee
Radionucleotide Diagnosis: Martin Charron, Reza Vali
SECTION VII. PSYCHOSOCIAL ASPECTS OF GASTROINTESTINAL DISORDERS
Gastrointestinal Features of Pediatric Illness Falsification: Paul Hyman, Brenda Bursch
Psychological Aspects of Chronic Disease: Steve Shlozman, Suzanne Bender
Adherence to Medical Regimens: Eyal Shemesh
SECTION VIII: PRINCIPLES OF CLINICAL INVESTIGATION
Outcomes Research on Diagnostic and Therapeutic Procedures: Jenifer R. Lightdale, Maireade McSweeney
Methodology: Statistical Analysis, Test Interpretation, Basic Principles of Screening with Application for Clinical Study: Patricia L. Hibberd, Andrew Cooper
Ethics/Regulatory Issues: P. Pearl O'Rourke, Jennifer P. Stevens

About the Author

Ronald E. Kleinman, MD, Professor of Pediatrics Harvard Medical School, Massachusetts General Hospital for Children, Boston, Massachusetts, USA.

Olivier-Jean Goulet, MD Professor of Pediatrics René Descartes University Necker-Enfants Malades Hospital Paris, France.

Giorgina Mieli-Vergani, MD, Director, Pediatric Liver Service Professor in Pediatric Hepatology Guy’s, King’s and St. Thomas School of Medicine King’s College, London, UK.

Ian R. Sanderson, MSc, MD, Professor of Paediatric Gastroenterology Head, Center for Gastroenterology Center for Digestive Disease Blizard Institute of Cell & Molecular Science London, UK.

Philip M. Sherman, MD, Professor of Pediatrics, Microbiology and Dentistry The Hospital for Sick Children University of Toronto, Toronto, Ontario, Canada.

Benjamin L. Shneider, MD, Professor of Pediatrics Director of Pediatric Hepatology Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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About the Author