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A comprehensive overview of the mechanisms underlying emerging pharmacologic approaches to interventional immunology

Table of Contents

Preface Section A: Human Immunology1. Systems Immunology2. Primary Immunodeficiencies3. Phenome-wide association study (PheWAS)4. Gene Regulatory Network5. TCR Repertoire Analysis Section B: Current and Emerging Pharmacological Targets6. TH177. TH98. TFH9. Regulatory T cells10. Regulatory B cells Section C: New Approaches11. Immune Tolerance Induction12. Humanized Mouse Models 13. Patient Stratification and Biomarkers

About the Author

Seng-Lai Tan is the Director of Cellular and Translational Immunology at EMD Serono Research and Development Institute. He is interested in advancing mechanistic understanding and thus proof of confidence of novel therapeutic agents for the treatment of autoimmune disease. Prior to joining EMD, Dr. Tan has led cross-functional teams in both large and small molecule drug discovery programs at Eli Lilly and Company, Amgen and Roche. Dr. Tan has over 50 publications in peer-reviewed journals in the areas spanning infectious diseases, oncology and immunology.