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|Format:||Hardback, 896 pages|
|Other Information: ||86 tables, 89 half-tones, 225 line drawings, 7 colour illustrations|
|Published In: ||United States, 01 March 1994|
More than 50 chapters examine the anatomy and physiology of the parathyroids; the structure, function, and actions of parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHRP); the causes of management of hypercalcemia due to PTHRP and other factors; and the pathophysiology, diagnosis, and treatment of clinical disorders of parathyroid function. The extensive section on clinical disorders includes: complete information on the molecular basis, clinical presentation, clinical course, and medical and surgical management of primary hyperparathyroidism; new methods for analyzing bone turnover in primary hyperparathyroidism; detailed discussions on familial forms of hypercalcemia, the parathyroids in renal disease, and hypoparathyroid states; an important chapter on parathyroid hormone as a potential therapy for osteoporosis.
Table of Contents
Embryology, anatomy, pathology; calcium homeostasis; regulation of parathyroid hormone by dietary calcium and vitamin D; interactions of parathyroid hormone with growth factors for bone; cellular actions of PTH on osteoblast and osteoclast differentiation; autocrine and paracrine functions of parathyroid tissue; parathyroid hormone secretory protein; parathyroid hormone and cyclic AMP, the early days; regulation of PTH biosynthesis and metabolism: genetic structure and control; structure/function analysis of parathyroid hormone and PTHRP; measurement of PTH in the circulation: clinical applications; non-target actions: parathyroid hormone and PTHRP as polyhormones; interact of PTH & PTH fragments with conventional & non-conventional receptor sites; receptors for PTH/PTHRP and other caliotropic hormones; G proteins as transducers of PTH action; biochemical mechanisms of PTH action; the biology of PTHRP: gene, structure, physiologically active forms; PTHRP as a cause of hypercalcemia; the skeletal and renal actions of PTHRP; assays for the actions of PTHRP: measurement of PTHRP in the circulation; other causes of hypercalcemia; local and ectopic secretion syndromes; management of PTH and PTHRP-dependent hypercalcemia; parathyroid growth-normal and abnormal; molecular basis of Primary Hyperparathyroidism; the spectrum of parathyroid tumours in hyperparathyroidism; clinical presentation of Primary Hyperparathyroidism; clinical course of Primary Hyperparathyroidism; newer markets of bone turnover in Primary Hyperparathyroidism; histomorphometric analysis of bone in Primary hyperparathyroidism; stone diseases in Primary Hyperparathyroidism; medical management of Primary Hyperparathyroidism; surgical management of Primary Hyperparathyroidism; preoperative localization of parathyroid tissue in primary hyperparathyroidism; control issues in management of hyperparathyroidism; parathyroid carcinoma; acute primary hyperparathyroidism; multiple endocrine Neoplasia I and other familial forms of hypercalcemia; multiple endocrine Neoplasia II; familial hypocalciuric hypercalcemia; the parathyroids in renal disease; pathophysiology; the parathyroids in renal disease; management; PTH in abnormalities of Vitamin D metabolism; hypoparathyroid states in the differential diagnosis of hypocalcemia; autoimmune aspects of hypoparathyroidism; the molecuclar basis of hypoparathyroidism; pseudohypoparathyroid-ism: clinical; biochemical and molecular features; rationale for and therapy of hypoparathyroidism; parathyroid hormone function and responsiveness in osteoporosis; parathyroid hormone as a potential therapy in osteoporosis; parathyroid function in Paget's disease; parathyroid function in magnesium deficiency.
|Publisher: ||Lippincott Williams and Wilkins|
|Dimensions: ||27.0 x 21.0 centimeters (2.30 kg)|