With its acclaimed author team, cutting-edge content, and coverage based on landmark experiments, Molecular Cell Biology has earned an impeccable reputation with instructors, edition after edition. The new Sixth Edition is the Molecular Cell Biology for a new generation, a dramatic revision of the classic text featuring two new co-authors, expanded coverage of immunology and development, and new media tools for students and instructors. NEW TO THIS EDITION * Increased clarity and accessibility, balancing coverage of the latest scientific developments with clear explanations of the fundamentals * New chapters: 'The Molecular Cell Biology of Development', 'Nerve Cells', and 'Immunology'. * Exciting new developments, including expanded coverage of proteomics, updated discussions of chromatin, evolution of chromosomes and the mitochondrion, molecular models, advances in light and electron microscopy, Reaction Oxygen Species (ROS), expanded coverage of RNAi, role of supercomplexes in electron transport, Human Epidermal Growth Factor Receptors (HERs), Myosin ATPase cycle, Kinesin 1 ATPase cycle, epithlial0to-mesenchymal transition and cancer, use of retrovirus infection for tracing cell lineage, axon guidance molecules, cancer stem cells, and use of DNA microarray analysis in tumor typing. The book is accompanied by a companion website (www.whfreeman.com/lodish6e), which supports learning and understanding through a wealth of supplementary material including online self-tests; animations and videos showing the dynamic nature of key cellular processes and important experimental techniques; and new podcasts narrated by the authors to give a deeper understanding of key figures in the text and a sense of the thrill of discovery.

Table of Contents

Life Begins with Cells Chemical Foundations Protein Structure and Function Basic Molecular Genetic Mechanisms Molecular Genetic Techniques Genes, Genomics, and Chromosomes Transcriptional Control of Gene Expression Post-transcriptional Gene Control Visualizing, Fractionating, and Culturing Cells Biomembrane Structure Transmembrane Transport of Ions and Small Molecules Cellular Energetics Moving Proteins into Membranes and Organelles Vesicular Traffic, Secretion, and Endocytosis Cell Signaling I: Signal Transduction and Short-term Cellular Responses Cell Signaling II: Signaling Pathways that Control Gene Activity Cell Organization and Movement I: Microfilaments Cell Organization and Movement II: Microtubules and Intermediate Filaments Integrating Cells into Tissues Regulating the Eukaryotic Cell Cycle Cell Birth, Lineage, and Death The Molecular Cell Biology of Development Nerve Cells Immunology Cancer

About the Author

HARVEY LODISH is Professor of Biology and Professor of Bioengineering at the Massachusetts Institute of Technology, USA, and a member of the Whitehead Institute for Biomedical Research. Dr. Lodish is also a member of the National Academy of Sciences and the American Academy of Arts and Sciences and was President (2004) of the American Society for Cell Biology. He is well known for his work on cell membrane physiology, particularly the biosynthesis of many cell-surface proteins, and on the cloning and functional analysis of several cell-surface receptor proteins, such as the erythropoietin and

Reviews

'The value of this incredibly extensive reference book lies in the attention it gives to explaining methods and techniques as fullly as is possible in a text that addresses so many aspects of this fast-expanding field.' - Dr. Chris Clegg, Journal of Biological Education 'Molecular Cell Biology literally does what it says on the tin: it provides a fantastic overview of much of the material studied in any molecular biology-based degree, and is thoroughly recommended.' - Emma Prior, Times Higher Educational Supplement